Acute treatment with ketamine and chronic treatment with minocycline exert antidepressant-like effects and antioxidant properties in rats subjected different stressful events

Maciel, Amanda L.; Abelaira, Helena M.; Moura, Airam B. de; Souza, Thays G. de; Rosa, Thayse; Matos, Danyela; Tuon, Talita; Garbossa, Leandro; Strassi, Ana Paula; Fileti, Maria Eduarda; Mathias, Khiany; Petronilho, Fabrícia; Quevedo, João; Réus, Gislaine Z.

doi:10.1016/j.brainresbull.2017.12.005

Cited by 29 publications

(8 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our findings indicate that CAT expression in hippocampus was lowered in animals exposed to the CMS procedure, and this finding is in line with other studies showing that chronic stress causes a reduction in cortical and hippocampal catalase activity. 34,35 Similar reductions in enzyme activity were observed in the erythrocytes of depressed patients. 69 However, CAT activity was also found to be increased in the serum of these patients, 70 is present only in the cytosol, Gpx4 is located in the membrane and mitochondria.…”

Section: Discussionsupporting

confidence: 65%

“…33 Similarly, previous studies found that chronic ozone inhalation induced depression-like symptoms, including anxiety, and reduced cortical and hippocampal SOD and CAT activity. 34,35 Interestingly, next study showed that the antidepressant therapy caused a reduction myeloperoxidase activity in the amygdala, hippocampus, amygdala and prefrontal cortex while SOD and CAT activity is believed to increase in nucleus accumbens of rat brain after antidepressant therapy. 36 Another important oxidative enzyme associated with depression is xanthine oxidase (XO); a post-mortem study had shown an increased level of XO in serum and the thalamus.…”

Section: Introductionmentioning

confidence: 94%

See 1 more Smart Citation

Effects of venlafaxine on the expression level and methylation status of genes involved in oxidative stress in rats exposed to a chronic mild stress

Wigner

Synowiec

Czarny

et al. 2020

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 65%

Section: Introductionmentioning

confidence: 94%

Effects of venlafaxine on the expression level and methylation status of genes involved in oxidative stress in rats exposed to a chronic mild stress

Wigner

Synowiec

Czarny

et al. 2020

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…A number of the published ketamine and stress studies do not report data on ketamine in unstressed controls (for example: [35,36]), and if this had been done more frequently, perhaps the current findings would already be established in C57BL/6J mice. It should also be pointed out that a recent study in unstressed male NIH mice found that subchronic (5 days) administration of 10 mg/kg ketamine, increased immobility time in the FST and tail suspension test [37]; however the repeated administration of drug in that study may modulate locomotor activity, which precludes direct comparison with our single injection findings in unstressed mice.…”

Section: Discussionmentioning

confidence: 94%

Stress-sensitive antidepressant-like effects of ketamine in the mouse forced swim test

2019

View full text Add to dashboard Cite

Major depression is a stress-linked disease with significant morbidity and the anesthetic drug ketamine is of growing interest in the treatment of depression, since in responsive individuals a single dose has rapid (within hours) antidepressant effects that can be sustained for over a week in some instances. This combination of fast action and a therapeutic effect that lasts far beyond the drug’s half-life points to a unique mechanism of action. In this reverse translational study, we investigate the degree to which ketamine counteracts stress-related depression-like behavioral responses by determining whether it affects unstressed animals similarly to stressed mice. To test this, male C57BL/6J mice were given a single injection of vehicle (0.9% saline; i.p.), 10 mg/kg ketamine, or 30 mg/kg ketamine, and were tested in the forced swim test (FST) 24 hours and 7 days later, as well as in the open field test on the eighth day. Unstressed mice had normal group housing, environmental enrichment, and experimenter pre-handling (5 days), whereas stressed animals were subjected to chronic mild stress (single housing, reduced enrichment and minimal handling), where some mice also had daily two-week unpredictable chronic stress (UCS). We find that ketamine (24 hours post-injection) decreases immobility and increases mobile (swimming) behavior (antidepressant-like effects) in UCS animals but does the opposite in unstressed mice, similar to recent human findings. In summary, these data suggest that chronic psychological stress interacts with ketamine treatment to modulate its effects in the C57BL/6J mouse FST, which reinforces the relevance of this test, and this strain of mice, to human, stress-induced depression.

show abstract

“…In the chronic mild stress (CMS) procedure, the most widely used animal model of depression ( Antoniuk et al, 2019 ; Willner, 2017 ), rats or mice display a wide range of behavioural and physiological changes characteristic of depression, which respond to chronic treatment with antidepressant drugs ( Hill et al, 2012 ; Willner, 1997 , 2017 ). Like TRD patients, rodents subjected to CMS show a rapid reversal of depression-related behaviours following ketamine treatment ( Maciel et al, 2018 ; Papp et al, 2017 ; Tornese et al, 2019 ; Wen et al, 2019 ) or DBS of the medial prefrontal cortex (mPFC) ( Dournes et al, 2013 ; Hamani et al, 2012 ; Lim et al, 2015 ; Veerakumar et al, 2014 ). The Wistar Kyoto (WKY) rat has long been considered to be resistant to antidepressant drug treatment, largely on the basis of acute studies using the forced swim test ( Lahmame et al, 1997 ; Lopez-Rubalcava and Lucki, 2000 ; Tejani-Butt et al, 2003 ).…”

Section: Introductionmentioning

confidence: 99%

Insufficiency of ventral hippocampus to medial prefrontal cortex transmission explains antidepressant non-response

et al. 2021

View full text Add to dashboard Cite

Background: There is extensive evidence that antidepressant drugs restore normal brain function by repairing damage to ventral hippocampus (vHPC) and medial prefrontal cortex (mPFC). While the damage is more extensive in hippocampus, the evidence of treatments, such as deep brain stimulation, suggests that functional changes in prefrontal cortex may be more critical. We hypothesized that antidepressant non-response may result from an insufficiency of transmission from vHPC to mPFC. Method: Antidepressant non-responsive Wistar Kyoto (WKY) rats were subjected to chronic mild stress (CMS), then treated with chronic daily administration of the antidepressant drug venlafaxine (VEN) and/or repeated weekly optogenetic stimulation (OGS) of afferents to mPFC originating from vHPC or dorsal HPC (dHPC). Results: As in many previous studies, CMS decreased sucrose intake, open-arm entries on the elevated plus maze (EPM), and novel object recognition (NOR). Neither VEN nor vHPC–mPFC OGS alone was effective in reversing the effects of CMS, but the combination of chronic VEN and repeated OGS restored normal behaviour on all three measures. dHPC–mPFC OGS restored normal behaviour in the EPM and NOR test irrespective of concomitant VEN treatment, and had no effect on sucrose intake. Conclusions: The synergism between VEN and vHPC–mPFC OGS supports the hypothesis that the antidepressant non-responsiveness of WKY rats results from a failure of antidepressant treatment fully to restore transmission in the vHPC–mPFC pathway.

show abstract

Acute treatment with ketamine and chronic treatment with minocycline exert antidepressant-like effects and antioxidant properties in rats subjected different stressful events

Cited by 29 publications

References 75 publications

Effects of venlafaxine on the expression level and methylation status of genes involved in oxidative stress in rats exposed to a chronic mild stress

Effects of venlafaxine on the expression level and methylation status of genes involved in oxidative stress in rats exposed to a chronic mild stress

Stress-sensitive antidepressant-like effects of ketamine in the mouse forced swim test

Insufficiency of ventral hippocampus to medial prefrontal cortex transmission explains antidepressant non-response

Contact Info

Product

Resources

About