Acylation-stimulating protein is a surrogate biomarker for acute myocardial infarction: Role of statins

Al-Kuraishy, Hayder M; Al-Gareeb, Ali I

doi:10.4103/0974-2727.208263

Cited by 27 publications

(22 citation statements)

References 27 publications

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“…BW and height were measured by stadiometer and then body mass index (BMI) was calculated as BW (kg)/height (m 2 ). [ 17 ] Blood pressure measurements were also determined at supine position during investigation period.…”

Section: Methodsmentioning

confidence: 99%

Differential effect of metformin and/or glyburide on apelin serum levels in patients with type 2 diabetes mellitus: Concepts and clinical practice

Al-Kuraishy

Al-Gareeb

Waheed

et al. 2018

J Adv Pharm Technol Res

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Type 2 diabetes mellitus (T2DM) is a metabolic disorder associated with abundant adipocytokine changes which may play an important role in the progression of insulin resistance and micro- and macro-vascular complications. Therefore, the objective of this study was to assess the differential effect of metformin alone or in combination with glyburide on apelin serum levels in patients with T2DM. In this case–control study, fifty patients with T2DM in the age range of 45–65 years and twenty-five healthy controls matched for age and body weight were recruited from single endocrinology center, subdivided according to the diabetic pharmacotherapy into: Group I: healthy controls (n = 25), Group II: T2DM patients on metformin (n = 15), Group III: T2DM patients on glyburide (n = 17), and Group IV: T2DM patients on metformin plus glyburide (n = 28). Biochemical and anthropometric variables in relation to apelin serum levels were estimated. Apelin serum levels were low in normal healthy controls compared to T2DM patients (P < 0.01). The differential effect of diabetic pharmacotherapy on apelin serum level was statistically significant (P < 0.01) compared to the controls, but insignificant when compared among used drugs (P > 0.05). Apelin level was high in T2DM compared to the controls; both metformin and glyburide might play a role in this elevation.

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Section: Methodsmentioning

confidence: 99%

Differential effect of metformin and/or glyburide on apelin serum levels in patients with type 2 diabetes mellitus: Concepts and clinical practice

Al-Kuraishy

Al-Gareeb

Waheed

et al. 2018

J Adv Pharm Technol Res

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“…Moreover, statins improve endothelial dysfunction in patients with toxoplasmosis due to the protective effect of statins. Besides, statins inhibit adhesion and proliferation of T. gondii (26,27).…”

Section: Discussionmentioning

confidence: 99%

Toxoplasmosis and Risk of Endothelial Dysfunction: Role of Oxidative Stress and Pro-Inflammatory Mediators

Al-Kuraishy

Al-Kuraishi

Al-Windy

et al. 2020

Arch Clin Infect Dis

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Background: Infection with Toxoplasma gondii (T. gondii) leads to activation of T-helper cells (Th-1 and Th-2) which are involved in the synthesis and release of different cytokines which may lead to endothelial dysfunction. Objectives: To evaluate the endothelial function in patients with acute toxoplasmosis. Methods: This case-control study involved 31 patients with toxoplasmosis aged 19 -47 years matched with 20 healthy subjects. Anti-T. gondii antibody (IgG, IgM, IgA) was determined by direct antigen-antibody reaction. Interleukin-6(IL-6), endothelin-1 (ET-1) and human malondialdehyde (MDA) serum levels were measured. Results: IgM, IgG and IgA levels were high in the infected patients compared with controls (P < 0.01). Furthermore, IL-6 serum level was high in the infected patients compared with controls (P < 0.01). In addition, ET-1 level was high in acute toxoplasmosis (7.29 ± 4.59 pg/mL) compared with controls (3.11 ± 1.69 pg/mL) (P < 0.01). In addition, MDA serum level was high (9.34 ± 4.17 nmol/mL) compared with controls (2.87 ± 1.13 nmol/mL), (P < 0.01). In acute toxoplasmosis IgM serum level was significantly correlated with IgG (r = 0.55, P = 0.001), IgA (r = 0.57, P = 0.0008), IL-6 (r = 0.45, P = 0.01), ET-1 (r = 0.51, P = 0.003) and MDA (r = 0.85, P = 0.0001). Conclusions: Acute toxoplasmosis is associated with significant oxidative stress and pro-inflammatory changes which contribute to development of endothelial dysfunction.

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“…Prostate cancer (PC) is the second leading cause of male malignancy death throughout the world [1]. The age is the strongest risk chance of getting prostate cancer, where the incidence of prostate cancer is rising rapidly after the age of 50 [2].…”

Section: Introductionmentioning

confidence: 99%

Prognostic Value of Sex-Determining Region Y-Box 2 (Sox2) in Prostate Cancer

Mohasen¹,

Ahmed²

2019

Asian J Pharm Clin Res

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Objectives: The objectives of this study were to evaluate the expression of sex-determining region-Y BOX 2 (SOX2) markers and their association with clinicopathological parameters. Methods: A cross-sectional study was carried out to involve 90 specimens from patients diagnosed with prostatic cancer (PC) and benign prostatic hypertrophy (BPH) compared with positive control (human bronchial tissue for SOX2 marker) with each run. Results: The highest proportion of specimens of PC was graded ≤7 by Gleason grading system (53.3%). There were significant associations (p<0.05) between all this cancer stem cell marker results and prevalence of PC. Positive SOX2 marker result was significantly associated with bad prognostic sign (81.3%, p=0.001). This marker was highly sensitive (100%) specificity (82.4%), with high accuracy (90%). Conclusion: There was a significant expression of SOX2 in prostate adenocarcinomas. SOX2 can be considered as a key regulator of tumor progression, aggressive behavior, and metastasis. Furthermore, it is a reliable marker for the early diagnosis and the designed chemotherapy of prostate adenocarcinomas.

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Acylation-stimulating protein is a surrogate biomarker for acute myocardial infarction: Role of statins

Cited by 27 publications

References 27 publications

Differential effect of metformin and/or glyburide on apelin serum levels in patients with type 2 diabetes mellitus: Concepts and clinical practice

Differential effect of metformin and/or glyburide on apelin serum levels in patients with type 2 diabetes mellitus: Concepts and clinical practice

Toxoplasmosis and Risk of Endothelial Dysfunction: Role of Oxidative Stress and Pro-Inflammatory Mediators

Prognostic Value of Sex-Determining Region Y-Box 2 (Sox2) in Prostate Cancer

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