Adalimumab use in pregnancy

Maintenance of the Remission Stage of Crohn's Disease with Adalimumab Therapy during Pregnancy

“…However, there is little evidence of the placental transfer of ADA to the fetus during pregnancy, although there is a case report describing the placental transfer of IFX during the latter period of pregnancy in which high infliximab levels in the serum of the infant were likely due to the occurrence of placental transfer, not breastfeeding (12). There are case reports documenting the successful use of ADA to treat CD during pregnancy, including one in which the patient received weekly dosing throughout pregnancy for a total of 38 doses (10,(13)(14)(15)(16). The Organization of Teratology Information Specialists (OTIS) has reported the findings of 33 women enrolled in a prospective study of ADA in pregnancy and an additional 89 pregnant women who were exposed to ADA and listed in a registry (16,17).…”

Inflammatory Bowel Disease in Pregnancy

“…Infliximab has been detected in the infants born to mothers receiving infliximab during the third trimester of pregnancy; however, to date, the long term effect of this placental transfer is unknown [50] . A published report for the successful use of adalimumab in pregnancy describes a patient with severely active disease at conception [51] . She was placed on adalimumab one month prior to conception and delivered of a normal growth infant without visible congenital anomalies.…”

Drug therapy in patients with rheumatic diseases during pregnancy and lactation

“…Описано несколько случаев «успешных» беременно-стей на фоне биологической терапии [166][167][168][169][170][171]. Однако нет достаточных данных о влиянии на фертильность и кормление грудью для адалимумаба (человеческого моно-клонального антитела ФНО α), ритуксимаба (монокло-нального антитела к CD20) и анакинры (антагониста ре-цептора интерлейкина 1).…”