2020
DOI: 10.1186/s12916-020-01806-4
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ADAM22/LGI1 complex as a new actionable target for breast cancer brain metastasis

Abstract: Background Metastatic breast cancer is a major cause of cancer-related deaths in woman. Brain metastasis is a common and devastating site of relapse for several breast cancer molecular subtypes, including oestrogen receptor-positive disease, with life expectancy of less than a year. While efforts have been devoted to developing therapeutics for extra-cranial metastasis, drug penetration of blood–brain barrier (BBB) remains a major clinical challenge. Defining molecular alterations in breast can… Show more

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Cited by 9 publications
(8 citation statements)
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“…Hydrodynamic size and Z-potential were comparable to other anti-TfR antibody functionalized brain lipid-based liposomes obtained in a previous work. 46 The round-shaped morphology, the hydrodynamic size and the Z-potential of the ext-LSs are comparable to those ones of empty LSs (Fig. S3; † 2r = 139.…”
Section: Papermentioning
confidence: 65%
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“…Hydrodynamic size and Z-potential were comparable to other anti-TfR antibody functionalized brain lipid-based liposomes obtained in a previous work. 46 The round-shaped morphology, the hydrodynamic size and the Z-potential of the ext-LSs are comparable to those ones of empty LSs (Fig. S3; † 2r = 139.…”
Section: Papermentioning
confidence: 65%
“…Extract-loaded liposomes (ext-LSs) were fabricated by using the thin-film evaporation method similarly as described in a previous work. 46 Specifically, 5 mg of brain lipids (Avanti Polar Lipids, Inc.) and 10 mg of a biotin-conjugated 1,2-distearoylsn-glycero-3-phosphoethanolamine-N-( polyethylene glycol)-5000 (biotin-PEG-DSPE; Avanti Polar Lipids, Inc.) were dissolved in 2 mL of chloroform and then transferred to an orbital shaker for evaporation (overnight at room temperature). The obtained dried lipids were subsequently re-hydrated in 2 mL of a water solution with 4 mg mL −1 extracts, extruded through a 100 nm pore polycarbonate membrane (Avanti® Mini Extruder; 11 passages through the membrane were performed), and finally dialyzed (300 kDa molecular weight cut off; Spectrum Laboratories, Inc.).…”
Section: Liposome Fabrication Functionalization and Characterizationmentioning
confidence: 99%
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“…Mouse anti-human monoclonal AR primary antibody (AR-318-L-CE, Leica Biosystems) was used to detect AR in a previously constructed tissue microarray (TMA) of primary breast carcinomas ( 21 ). TMAs were scanned at 40× using a high-resolution digital scanner (Philips Digital Solutions) and the whole slide images were viewed remotely using QuPath software.…”
Section: Methodsmentioning
confidence: 99%