ADAM33 as a Psoriasis Susceptibility Gene in the Han Population of Northeastern China

Zhou, Jing; Sun, Donglin; Xu, Lei; Sun, Liyan; Fu, Songbin; Li, Yuzhen

doi:10.1159/000335417

Cited by 9 publications

(5 citation statements)

References 42 publications

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“…Some gene polymorphisms have been shown to be associated with psoriasis. In our previous study, we found that a gene for disintegrin and metalloprotease‐33 is a psoriasis susceptibility gene in the Han population of northeastern China, and we also reported a new susceptibility locus for psoriasis within the late cornified envelope (LCE) gene cluster . However, how many additional gene polymorphisms are also involved in individual susceptibility to psoriasis remains unknown.…”

Section: Introductionmentioning

confidence: 98%

Association of angiopoietin-1, angiopoietin-2 and caspase-5 polymorphisms with psoriasis vulgaris

Lin

Zhou

et al. 2015

Clin Exp Dermatol

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Section: Introductionmentioning

confidence: 98%

Association of angiopoietin-1, angiopoietin-2 and caspase-5 polymorphisms with psoriasis vulgaris

Lin

Zhou

et al. 2015

Clin Exp Dermatol

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“…CARD8 may be involved in psoriasis development as a genetic marker or a causative polymorphism. Previously, our team identified a relationship between several other genetic polymorphisms and PsV [14,[27][28][29]. We will compile these findings to further explore the relationship between these genes and PsV in the Han population of northeastern China.…”

Section: Resultsmentioning

confidence: 93%

A New Risk Polymorphism rs10403848 of CARD8 Significantly Associated with Psoriasis Vulgaris in Northeastern China

Pei

Liu

Hao

et al. 2020

BioMed Research International

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Caspase recruitment domain family member 8 (CARD8) is an adaptor molecule that negatively regulates nuclear factor-κB (NF-κB) activation, interleukin (IL)-1β secretion, and apoptosis. These play important roles in the pathogenesis of psoriasis. Genetic variants of CARD8 have been associated with an increased risk of several inflammatory diseases and psoriasis in Europe. However, nothing is known about the association of the polymorphisms of CARD8 and psoriasis vulgaris (PsV) in the Han population of northeastern China. To investigate the potential association between them, we designed a case-control study to genotype four selected single nucleotide polymorphisms (SNPs) using the improved multiplex ligation reaction (iMLDR) method. Model-based single SNP frequentist-test and haplotype association studies were performed to assess the association between SNPs and PsV. The results showed that the intron SNP rs10403848 was significantly associated with PsV (additive model p=0.0418, p′=0.0411, and statistical power 0.1902; heterozygous model p=0.0418, p′=0.0164, and statistical power 0.9406). A potential risk locus of nonsynonymous SNP rs2043211 found in the European population did not show a significant association in our study. We found that the polymorphism rs10403848 in CARD8 is significantly associated with PsV risk in the Han population of northeastern China. CARD8 may be involved in PsV in this population, as in the European population, but a different genetic process should be considered for the heterogeneity of risk loci.

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“…MMP-1 [160], MMP-2 [45,157,160], MMP-3 [25], MMP-7 [109], MMP-8 [38], MMP-9 [5,14,45,157,160], MMP-12 [160,167], MMP-14 [45], MMP-15 [45], MMP-19 [166], MMP-26 [167], MMP-28 [196], ADAM-10 [109], ADAM-12 [109], ADAM-17 [75], ADAM-33 [3,198] • Adalimumab/Infliximab (anti-TNF-α Ab)…”

Section: Psoriasismentioning

confidence: 99%

Ab locks for improving the selectivity and safety of antibody drugs

Lin

Chuang

et al. 2020

J Biomed Sci

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Monoclonal antibodies (mAbs) are a major targeted therapy for malignancies, infectious diseases, autoimmune diseases, transplant rejection and chronic inflammatory diseases due to their antigen specificity and longer half-life than conventional drugs. However, long-term systemic antigen neutralization by mAbs may cause severe adverse events. Improving the selectivity of mAbs to distinguish target antigens at the disease site from normal healthy tissue and reducing severe adverse events caused by the mechanisms-of-action of mAbs is still a pressing need. Development of pro-antibodies (pro-Abs) by installing a protease-cleavable Ab lock is a novel and advanced recombinant Ab-based strategy that efficiently masks the antigen binding ability of mAbs in the normal state and selectively “turns on” the mAb activity when the pro-Ab reaches the proteolytic protease-overexpressed diseased tissue. In this review, we discuss the design and advantages/disadvantages of different Ab lock strategies, focusing particularly on spatial-hindrance-based and affinity peptide-based approaches. We expect that the development of different masking strategies for mAbs will benefit the local reactivity of mAbs at the disease site, increase the therapeutic efficacy and safety of long-term treatment with mAbs in chronic diseases and even permit scientists to develop Ab drugs for formerly undruggable targets and satisfy the unmet medical needs of mAb therapy.

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ADAM33 as a Psoriasis Susceptibility Gene in the Han Population of Northeastern China

Cited by 9 publications

References 42 publications

Association of angiopoietin-1, angiopoietin-2 and caspase-5 polymorphisms with psoriasis vulgaris

Association of angiopoietin-1, angiopoietin-2 and caspase-5 polymorphisms with psoriasis vulgaris

A New Risk Polymorphism rs10403848 of CARD8 Significantly Associated with Psoriasis Vulgaris in Northeastern China

Ab locks for improving the selectivity and safety of antibody drugs

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