2019
DOI: 10.1042/cs20180906
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ADAM8 in invasive cancers: links to tumor progression, metastasis, and chemoresistance

Abstract: Ectodomain shedding of extracellular and membrane proteins is of fundamental importance for cell–cell communication in neoplasias. A Disintegrin And Metalloproteinase (ADAM) proteases constitute a family of multifunctional, membrane-bound proteins with traditional sheddase functions. Their protumorigenic potential has been attributed to both, essential (ADAM10 and ADAM17) and ‘dispensable’ ADAM proteases (ADAM8, 9, 12, 15, and 19). Of specific interest in this review is the ADAM proteinase ADAM8 that has been … Show more

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Cited by 61 publications
(56 citation statements)
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“…high expression levels are unfavorable for glioma patients (He et al 2012). More recently, ADAM8 expression was correlated to the occurrence of glioma-associated macrophages/microglia (GAMMs, (Gjorgjevski et al 2019), however the function of ADAM8 in tumor cells and in GAMMs remains elusive and tumor promoting effects in the glioma microenvironment can be postulated, since in all tumor entities described so far, ADAM8 is responsible for tumor invasion, migration, and chemoresistance, leading to poor clinical outcomes (Conrad et al 2019).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…high expression levels are unfavorable for glioma patients (He et al 2012). More recently, ADAM8 expression was correlated to the occurrence of glioma-associated macrophages/microglia (GAMMs, (Gjorgjevski et al 2019), however the function of ADAM8 in tumor cells and in GAMMs remains elusive and tumor promoting effects in the glioma microenvironment can be postulated, since in all tumor entities described so far, ADAM8 is responsible for tumor invasion, migration, and chemoresistance, leading to poor clinical outcomes (Conrad et al 2019).…”
Section: Discussionmentioning
confidence: 99%
“…High expression levels of ADAM8 in tumor cells have been shown to be associated with invasiveness and metastasis of carcinomas, such as breast and pancreatic tumors (Conrad et al 2017;Romagnoli et al 2014;Schlomann et al 2015). For these cancers as well as for glioma, high ADAM8 expression levels correlate with poor patient prognosis (Conrad et al 2019).…”
Section: Introductionmentioning
confidence: 99%
“…ADAM8 is a proteolytically active member of the ADAM8 protease family. Increase expression of ADAM8 was observed in breast cancer [27] , lung adenocarcinoma [28] and pancreatic cancer [29] .ADAM8 has been shown to cleave important extracellular matrix (ECM) components of the tumor stroma such as growth factors or cell surface protein [30] . Epidermal growth factor has been demonstrated to reduce cell attachment, cell-cell interaction, and cell spreading; but suppressed expressions of cyclin A, D1 and cdk2 [31] .…”
Section: Discussionmentioning
confidence: 99%
“…The key to the activation of all ADAM family members is the removal of the pro-domain by proprotein convertases, as described above. However, the pro-domain of the family member ADAM8 is removed in an autocatalytic process [ 30 ]. Expression of ADAM8 itself is regulated by inflammatory cytokines such as TNFα, IL-1β, IL-4 and IL-13 [ 30 ].…”
Section: Adam Proteasesmentioning
confidence: 99%
“…However, the pro-domain of the family member ADAM8 is removed in an autocatalytic process [ 30 ]. Expression of ADAM8 itself is regulated by inflammatory cytokines such as TNFα, IL-1β, IL-4 and IL-13 [ 30 ]. ADAM12 is stored as active protease intracellularly and substrate exposure occurs via trafficking to the plasma membrane [ 31 ].…”
Section: Adam Proteasesmentioning
confidence: 99%