Adaptation and clonal selection models of castration‐resistant prostate cancer: Current perspective

Mashaly, Ahmed; Li, Long-Cheng

doi:10.1111/iju.12005

Cited by 46 publications

(34 citation statements)

References 78 publications

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“…These models propose that genomic instability within the primary tumor results in cell diversity due to mutations in subset of tumor cells (e.g. review Ahmed, Li 2013 [48] ). In additional, the cancer stem cell theory has been proposed [38,49,50] .…”

Section: Modern Biochemistry and Post-genomic Technologies In Researcmentioning

confidence: 99%

Modern Biochemistry in Research of Human Malignant Cells and Experimental Oncology

Шишкин

2016

Journal of Biochemistry and Molecular Biology Research

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characteristics and the gene expression patterns. Thus, the use of malignant cell lines ex vivo (as models of human cancers) is an important trend in search for key molecules of carcinogenesis in experimental oncology. EDITORIALThe biochemistry has a place of honor among the life sciences largely due to its fantastic success in 20 th century. Traditional biochemistry started with the study of chemical components of living organisms and their metabolism that provides life itself, and with description of the main types of biopolymers and other biomolecules. At that time technologies allowing to determine sequence of monomers in complex polymers such as nucleic acids and proteins (sequencing technologies) were designed. As a result, in the 80s of the 20 th century the entire human mitochondrial genome was identified, heavy and light mitochondrial DNA strands maps were constructed and their nucleotide sequences were determined [1,2] . Further similar studies were concerned with the complete genome sequencing of different bacteria and some eukaryotes [3][4][5] . In the last decade of 20 th century the DNA sequencing of the human nuclear genome was started that influenced the development of the life sciences [6][7][8] . To achieve the goal of determining the DNA sequence of the entire human genome the considerable resources of the international ABSTRACTModern biochemistry or biochemistry of 21th century is developing in many traditional fields: investigations of proteins, nucleic acids, lipids, carbohydrates, metabolites and metabolic processes, etc, however it has gained new features that based on success of Human Genome Project and on application of high performance technologies (post-genomic technologies). As a result, at the turn of the 21st century some new scientific disciplines, named "OMICS" (proteomics, transcriptomics, lipidomics, glycomics, metabolomics, etc) were created through advances in the biochemistry. Currently "OMICS" and post-genomic technologies are involved in mainstream of cancer research, including studies of human malignant cells. Since malignant tumors consist of heterogeneous cancer cells, the cultured cell lines have some advantages over biopsy simples for studies aimed at understanding the molecular basis of carcinogenesis. The malignant human cell lines differ considerably in their origin from tissues or organs, and therefore they vary widely in the differentiation EDITORIAL

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Section: Modern Biochemistry and Post-genomic Technologies In Researcmentioning

confidence: 99%

Modern Biochemistry in Research of Human Malignant Cells and Experimental Oncology

Шишкин

2016

Journal of Biochemistry and Molecular Biology Research

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“…It is an open question whether castration resistance evolves from selection acting on a small population of CR cells that exist in the tumor before treatment (the selection hypothesis), or whether CR strains arise during treatment (the adaptation hypothesis), or both (28,29,30). The role accommodative changes play is also not well understood.…”

Section: Formulation Of the Mathematical Modelmentioning

confidence: 99%

Mechanisms of Resistance to Intermittent Androgen Deprivation in Patients with Prostate Cancer Identified by a Novel Computational Method

et al. 2014

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For progressive prostate cancer, intermittent androgen deprivation (IAD) is one of the most common and effective treatments. Although this treatment is usually initially effective at regressing tumors, most patients eventually develop castration-resistant prostate cancer (CRPC), for which there is no effective treatment and is generally fatal. Although several biologic mechanisms leading to CRPC development and their relative frequencies have been identified, it is difficult to determine which mechanisms of resistance are developing in a given patient. Personalized therapy that identifies and targets specific mechanisms of resistance developing in individual patients is likely one of the most promising methods of future cancer therapy. Prostate-specific antigen (PSA) is a biomarker for monitoring tumor progression. We incorporated a cell death rate (CDR) function into a previous dynamical PSA model that was highly accurate at fitting clinical PSA data for 7 patients. The mechanism of action of IAD is largely induction of apoptosis, and each mechanism of resistance varies in its CDR dynamics. Thus, we analyze the CDR levels and their timedependent oscillations to identify mechanisms of resistance to IAD developing in individual patients. Cancer Res; 74(14); 3673-83. Ó2014 AACR.

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“…and solutions are independent, so each population grows as in (1). The only constraint will be that the total amount of the carrying capacities is a constant:…”

Section: Two Populations Modelmentioning

confidence: 99%

“…Under the pressure of an anti-androgen drug, the second group becomes gradually dominant and causes the clinical relapse and the emergence of a disseminated castration-resistant prostate cancer. Two main models were developed to depict the evolution of the ratio between the sensitive and resistant cells: the 'adaptation' model and the 'clonal selection' model ( [1], [2], [3]). The adaptation model suggests that prostate cancer is initially composed by homogeneous cells, in terms of their androgen requirement, and castration resistance emerges through genetic or epigenetic switches of androgendependent cells to androgen-independent cells.…”

Section: Introductionmentioning

confidence: 99%

A two population model of cancer growth with fixed capacity

Stura

Gabriele

Guiot

2014

Proceedings of the 2014 6th International Advanced Research Workshop on in Silico Oncology and Cancer Investigation - The CHIC

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Abstract-Cancer is not a homogenous tissue, but a very complex mix of different cell populations; moreover, a delicate equilibrium exists between these components of tumor mass. In this work we address prostate cancer although the methods presented can be generalized to most tumour types. The aim of our work is to model the behaviour of the different cell populations within the tumour and simulate changes which occur during natural evolution and treatments.

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Adaptation and clonal selection models of castration‐resistant prostate cancer: Current perspective

Cited by 46 publications

References 78 publications

Modern Biochemistry in Research of Human Malignant Cells and Experimental Oncology

Modern Biochemistry in Research of Human Malignant Cells and Experimental Oncology

Mechanisms of Resistance to Intermittent Androgen Deprivation in Patients with Prostate Cancer Identified by a Novel Computational Method

A two population model of cancer growth with fixed capacity

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