Adaptation and remodeling of vascular wall; biomechanical response to hypertension

Hayashi, Kozaburo; Naiki, Takeru

doi:10.1016/j.jmbbm.2008.05.002

Cited by 136 publications

(99 citation statements)

References 81 publications

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“…To introduce residual stresses in the unloaded configuration, we make use of the general idea that the arterial wall is able to remodel its microstructure toward a preferred biomechanical state. More specifically, the hypothesis that the circumferential stress gradient is minimal at physiological pressure (P = 13.3 kPa) and axial pre-stretch (Chuong and Fung 1986;Takamizawa and Hayashi 1987;Hayashi and Naiki 2009) is translated into a second objective function ϑ(α):…”

Section: Estimation Proceduresmentioning

confidence: 99%

The fiber orientation in the coronary arterial wall at physiological loading evaluated with a two-fiber constitutive model

Horst

Broek

Vosse

et al. 2011

Biomech Model Mechanobiol

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A patient-specific mechanical description of the coronary arterial wall is indispensable for individualized diagnosis and treatment of coronary artery disease. A way to determine the artery's mechanical properties is to fit the parameters of a constitutive model to patient-specific experimental data. Clinical data, however, essentially lack information about the stress-free geometry of an artery, which is necessary for constitutive modeling. In previous research, it has been shown that a way to circumvent this problem is to impose extra modeling constraints on the parameter estimation procedure. In this study, we propose a new modeling constraint concerning the in-situ fiber orientation (β phys ). β phys , which is a major contributor to the arterial stress-strain behavior, was determined for porcine and human coronary arteries using a mixed numerical-experimental method. The in-situ situation was mimicked using in-vitro experiments at a physiological axial pre-stretch, in which pressure-radius and pressure-axial force were measured. A single-layered, hyperelastic, thick-walled, two-fiber material model was accurately fitted to the experimental data, enabling the computation of stress, strain, and fiber orientation. β phys was found to be almost equal for all vessels measured (36.4 ± 0.3) • , which theoretically can be explained using netting analysis. In further research, this finding can be used as an extra modeling constraint in parameter estimation from clinical data.

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Section: Estimation Proceduresmentioning

confidence: 99%

The fiber orientation in the coronary arterial wall at physiological loading evaluated with a two-fiber constitutive model

Horst

Broek

Vosse

et al. 2011

Biomech Model Mechanobiol

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“…Taken together, chronic adaptation acts to increase compliance, which has been described as "compliance resetting" (12), which was first observed in rat carotid arteries (14,19). Furthermore, numerous studies of hypertensive humans have reported that conductance artery compliance is similar to (31) or even higher (12,18,30) than normotensive subjects when measured at similar pressures. Third, increases in compliances were predicted upstream of an aortic coarctation (Fig.…”

Section: Judicious Use Of Simplifying Assumptions Allowed Identificatmentioning

confidence: 93%

Aortic pulse pressure homeostasis emerges from physiological adaptation of systemic arteries to local mechanical stresses

Nguyen

Tüzün²,

Quick

2016

American Journal of Physiology-Regulatory, Integrative and Comp

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Nguyen PH, Tuzun E, Quick CM. Aortic pulse pressure homeostasis emerges from physiological adaptation of systemic arteries to local mechanical stresses. Am J Physiol Regul Integr Comp Physiol 311: R522-R531, 2016. First published June 15, 2016 doi:10.1152/ajpregu.00402.2015.-Aortic pulse pressure arises from the interaction of the heart, the systemic arterial system, and peripheral microcirculations. The complex interaction between hemodynamics and arterial remodeling precludes the ability to experimentally ascribe changes in aortic pulse pressure to particular adaptive responses. Therefore, the purpose of the present work was to use a human systemic arterial system model to test the hypothesis that pulse pressure homeostasis can emerge from physiological adaptation of systemic arteries to local mechanical stresses. First, we assumed a systemic arterial system that had a realistic topology consisting of 121 arterial segments. Then the relationships of pulsatile blood pressures and flows in arterial segments were characterized by standard pulse transmission equations. Finally, each arterial segment was assumed to remodel to local stresses following three simple rules: 1) increases in endothelial shear stress increases radius, 2) increases in wall circumferential stress increases wall thickness, and 3) increases in wall circumferential stress decreases wall stiffness. Simulation of adaptation by iteratively calculating pulsatile hemodynamics, mechanical stresses, and vascular remodeling led to a general behavior in response to mechanical perturbations: initial increases in pulse pressure led to increased arterial compliances, and decreases in pulse pressure led to decreased compliances. Consequently, vascular adaptation returned pulse pressures back toward baseline conditions. This behavior manifested when modeling physiological adaptive responses to changes in cardiac output, changes in peripheral resistances, and changes in local arterial radii. The present work, thus, revealed that pulse pressure homeostasis emerges from physiological adaptation of systemic arteries to local mechanical stresses. vascular adaptation; compliance resetting; pulsatile hemodynamics; multiscale modeling AORTIC PULSE PRESSURE APPEARS to be homeostatic despite the lack of global regulatory mechanisms affecting elastic arteries. Cardiac output, peripheral resistances, and arterial compliances are the primary mechanical determinants of aortic pressures (40,47). Whereas mean pressure is predominantly determined by cardiac output and peripheral resistance, pulse pressure (systolic-diastolic) is also affected by compliance (the change in volume per change in transmural pressure) of the large elastic arteries (69). As arterial compliances decrease, pulse pressures tend to increase (40,41,47,48). Acutely, mean pressure and pulse pressure are physiologically coupled by feedback mechanisms: when pulse pressure rises, stretch-sensitive baroreceptors lower peripheral resistance, i.e., the baroreflex, which, in turn, lowers mean pressure. Furthe...

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“…(21) Currently it is known that arterial blood vessels are prone to deformation when exposed to elevated blood pressure. (13,(23)(24)(25)(26) However, a clear link between vascular risk factors and kinking and coiling is still not fully understood.…”

Section: Epidemiologymentioning

confidence: 99%

Clinical implications of internal carotid artery tortuosity, kinking and coiling: a systematic review

Zenteno¹,

Zavaleta²,

Lee³

2014

Romanian Neurosurgery

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Anatomical variations of the internal carotid artery are diverse. Abnormalities in their geometry and paths are commonly identified by ultrasonography and angiography. The surgical correction of symptomatic CAs is better in preventing stroke compared with best medical therapy, as well as it completely eliminates the symptoms in patients with nonhemispheric symptoms.The ICA anomalies may be dangerous and represent a risk factor for massive bleeding. Suture ligatures can penetrate and occlude torn vessels, scalpels or biting instruments can lacerate vessels, and indirectly conducted electric cauterization can burn the soft of bony tissues.

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Adaptation and remodeling of vascular wall; biomechanical response to hypertension

Cited by 136 publications

References 81 publications

The fiber orientation in the coronary arterial wall at physiological loading evaluated with a two-fiber constitutive model

The fiber orientation in the coronary arterial wall at physiological loading evaluated with a two-fiber constitutive model

Aortic pulse pressure homeostasis emerges from physiological adaptation of systemic arteries to local mechanical stresses

Clinical implications of internal carotid artery tortuosity, kinking and coiling: a systematic review

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