Adaptation and validation of the Indonesian version of the FRAIL scale and the SARC-F in older adults

Dwipa, Lazuardhi; Apandi, Muhamad; Utomo, Priyo Panji; Hasmirani, Mira; Rakhimullah, Alif Bagus; Yulianto, Fajar Awalia; Pratiwi, Yuni Susanti

doi:10.12809/ajgg-2020-436-oa

Cited by 11 publications

(7 citation statements)

References 17 publications

(26 reference statements)

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“…Sarcopenia was measured with the Ina-SARC-F questionnaire, an Indonesian adaptation of the SARC-F score, which is interpreted as sarcopenia if the score was > 4 [5,15]. Sarcopenia was also measured based on muscle mass according to AWGS (Asian Working Group for Sarcopenia) criteria, which is ASMI < 7 kg/m 2 in men or < 5.7 kg/m 2 in women [5,15].…”

Section: De Nitionmentioning

confidence: 99%

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Association of Frailty Syndrome and Sarcopenia With Subclinical Atherosclerosis in Older Patients

Dwipa,

Gukguk,

Hidayat

et al. 2024

Preprint

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Background Cardiovascular disease rises significantly with age. In aging, there are changes in body composition and functional status that lead to a decreased muscle mass and strength leading to sarcopenia and frailty syndrome. Frailty syndrome and sarcopenia are predicted to accelerate atherosclerosis, but the study in elderly was very limited. This study aims to find the association of frailty syndrome and sarcopenia with subclinical atherosclerosis in older patients. Methods This study was an observational study. Primary data were collected with cross-sectional study approach at Outpatient Clinic of Hasan Sadikin General Hospital, Bandung during April - August 2023 who had no history of cardiovascular disease. Frailty syndrome was measured by Ina-FRAIL score while sarcopenia was measured by Ina-SARC-F score and appendicular skeletal muscle index (ASMI). Body composition was measured by bioimpedance analysis. Subclinical atherosclerosis was defined by the presence of carotid artery plaques evaluated by ultrasonographic examination. Results The study was conducted in 144 older patients who met the inclusion criteria. Frailty syndrome (OR 10.09, 95% CI 1.04–97.80, p value 0.046) and older age (OR 6.09, 95% CI 1.27–29.17, p value 0.024) were associated with carotid plaques. Sarcopenia based on Ina-SARC-F score (OR 1.30 95% CI 0.27–6.35, p value 0.742) and based on ASMI (OR 0.71, 95% CI 0.19–2.71, p value 0.756) were not associated with carotid plaque. Conclusion Frailty syndrome is associated with the presence of carotid plaques, while sarcopenia has not been proven yet.

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Section: De Nitionmentioning

confidence: 99%

“…Sarcopenia and frailty syndrome are initiated by decreased muscle mass and impairment of functional status, while cardiovascular events are preceded by atherosclerosis [7,14]. Screening of sarcopenia using Ina-SARC-F score and the Ina-FRAIL score for measured frailty syndrome are needed for early and rapid detection [5,7,15].…”

Section: Introductionmentioning

confidence: 99%

Association of Frailty Syndrome and Sarcopenia With Subclinical Atherosclerosis in Older Patients

Dwipa,

Gukguk,

Hidayat

et al. 2024

Preprint

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“…During face-to-face interviews with the patients, trained nursing staff used the Indonesian version of the FRAIL scale, which has been proven to be a reliable and valid screening tool for frailty syndrome assessment. 40 The FRAIL scale (FS) consists of five components: fatigue, resistance, ambulation, sickness, and weight loss. The FRAIL scale scores range from 0 to 5 (one point for each component; 0 represents best to 5 represents worst) and indicate robust (0), pre-frail (1 to 2), frail (3 to 5).…”

Section: Frailty Assessmentmentioning

confidence: 99%

Exploring the moderating effects of SIRT1 and gene polymorphisms rs7895833 on the relationship between hemoglobin levels and physical frailty in elderly adults with comorbid chronic diseases: A moderated mediation analysis

Ardinata,

Sari Harahap,

Lubis

et al. 2024

F1000Res

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Background Relationship age, hemoglobin, and physical frailty have all been investigated in older people with more than one chronic disease. There has been little analysis of the relationship between hemoglobin, age, physical frailty, plasma levels of Sirtuin1 (SIRT1), and the gene polymorphism (SNP) rs7895833 A>G. The goal of this study was to find out how SIRT1 level, SNP rs7895833, hemoglobin, age, and physical frailty (frail score) are related in older Indonesian adults with comorbid chronic diseases. Methods This was an observational study. Demographic and clinical data were retrieved from the electronic health records of Universitas Sumatera Utara Hospital, Medan, Indonesia. Physical frailty, SIRT1 level, and SNP rs7895833 were measured using an appropriate and valid method. Purposive sampling was used to determine the eligibility of 132 elderly adults from November 2022 to February 2023. Results The indirect effect of hemoglobin on the frail score (FS) through age was negative and significant, according to a conditional mediation analysis (β=-0.0731; p=0.023). Meanwhile, the direct effect of hemoglobin on the FS was negative and not significant (β=0.1632; p=0.052). According to the conditional moderated mediation analysis, the size of the direct effect of age on FS was increased by genotype AG-GG and SIRT1 level (βlow=0.2647; p=0.002, βmiddle=0.2956; p<0.001, and βhigh=0.319; p<0.001). The size of the conditional indirect effect of Hemoglobin on FS through age was negative and significantly increased by SNP genotype AG-GG and SIRT1 level (βlow=-0.0647; p=0.032, βmiddle=-0.0723; p=0.024, and βhigh=-0.078; p=0.02). Conclusions Higher plasma levels of SIRT1 and the SNP genotype AG-GG may both contribute to physical frailty in the elderly population. Hemoglobin levels in the blood fall with age, which can negatively impact older persons who already have chronic diseases. However, the interactions between these factors are intricate, requiring more study to completely understand the processes underlying development.

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“…This questionnaire has gone through a process of translation, adapted, and validation. [18] Anthropometric measurements https://oamjms.eu/index.php/mjms/index Subjects in this study were weighed using minimum clothing according to standard procedures using measuring instruments that were calibrated and assisted by trained research assistants. [17] The subject's body weight was measured using an electronic scale (Tanita MC 980 MA) and recorded to approx.…”

Section: Research and Measurement Proceduresmentioning

confidence: 99%

“…In Indonesia, the prevalence of outpatient frailty syndrome in the 13 main referral hospitals was 25.2%. [16], [17], [18].…”

Section: Introductionmentioning

confidence: 99%

The Immunogenicity and Safety of Influenza Vaccines among Indonesian Older adult

Dwipa

Usman

Rakhimullah

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: Immunosenescence, frailty, sarcopenia, and Vitamin D deficiency were thought of having a negative influence on adequate immune response following vaccination. Epidemiological data related to influenza vaccination and its immunogenicity and safety in Indonesia are still scarce. AIM: This study aimed to assess the immunogenicity and safety of the influenza vaccine in older adults in Indonesia and common related conditions. METHODS: This study was a one-group, pre-test, post-test, quasi-experimental study. The vaccine used was a trivalent type. Immunogenicity was assessed according to rate of seropositivity and seroconversion based on hemagglutination inhibition antibody titer. Immunization safety was assessed according to adverse events following immunization (AEFI). RESULTS: A total of 227 subjects were involved in this study. Antibody titers were significantly increased after 28-day influenza vaccination for all strains (p < 0.001). Seropositive rate in 28-day post-vaccination for A/H1N1, A/H3N2, and influenza B was 98.7%, 99.1%, and 97.4%, respectively. Meanwhile, the seroconversion rate for A/H1N1, A/H3N2, and influenza B strains was 54.2%, 66.1%, and 60.4%, respectively. The conditions of the frailty status, sarcopenia, and Vitamin D level were not associated with either seroconversion or seropositive status, both at baseline and endpoint. AEFI was occurred on seven subjects (3.08%) with pain at the injection site and one subject (0.44%) with arm tenderness. CONCLUSION: Influenza vaccination showed adequate immune response and safety regardless of the frailty status, sarcopenia, or Vitamin D level. This result strengthened the importance of influenza vaccine administration in Indonesia older adults.

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Adaptation and validation of the Indonesian version of the FRAIL scale and the SARC-F in older adults

Cited by 11 publications

References 17 publications

Association of Frailty Syndrome and Sarcopenia With Subclinical Atherosclerosis in Older Patients

Association of Frailty Syndrome and Sarcopenia With Subclinical Atherosclerosis in Older Patients

Exploring the moderating effects of SIRT1 and gene polymorphisms rs7895833 on the relationship between hemoglobin levels and physical frailty in elderly adults with comorbid chronic diseases: A moderated mediation analysis

The Immunogenicity and Safety of Influenza Vaccines among Indonesian Older adult

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