Adaptation of lactose maldigesters to continued milk intakes

Johnson, Austin; Semenya, J G; Buchowski, Maciej S.; Enwonwu, Cyril O.; Scrimshaw, Nevin S.

doi:10.1093/ajcn/58.6.879

Cited by 83 publications

(45 citation statements)

References 23 publications

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“…Alternatively, pregnancy may cause blunting of the hydrogen curve that can be due to a change in transit time, adaptation or as yet unrecognised factors. Nevertheless, the prevalence rates of lactose maldigestion in pregnant subjects and nonpregnant controls were similar to those found in previous reports of African-American women 4,11 . When comparing the symptoms reported by subjects in the early period of pregnancy with the controls, subjects reported significantly less flatulence and diarrhoea.…”

Section: Discussionsupporting

confidence: 90%

Lactose digestion in pregnant African-Americans

Paige

Witter

Bronner

et al. 2003

Public Health Nutr.

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Objective: This paper reports on the status of lactose digestion during early and late pregnancy and at 8 weeks postpartum in an African-American population. The hypothesis is that lactose digestion and milk tolerance do not change throughout pregnancy and do not differ from those of non-pregnant African-American women. Design and subjects: This longitudinal study determined lactose digestion after ingesting 240 ml of 1% fat milk containing 12 g of lactose at: (1) early pregnancy, prior to 16 weeks (n ¼ 148); (2) late pregnancy, 30-35 weeks (n ¼ 77); and (3) 8 weeks postpartum (n ¼ 93). One hundred and one comparably matched non-pregnant African-American women served as controls. Results: Prevalence of lactose digestion, as measured by breath hydrogen, was 80.2% in the control women, 66.2% in early pregnancy, 68.8% in late pregnancy and 75.3% postpartum. The prevalence of women reporting symptoms was approximately 20% regardless of lactose absorption status. However, the control women reported significantly more symptoms than did the pregnant women. Conclusions: This study indicates that there is no significant change in lactose digestion during pregnancy. The prevalence of lactose intolerance for the pregnant African-American women studied is similar to that for non-pregnant African-American women and similar to previous prevalence reports in adult African-Americans. There was no change in the tolerance of lactose noted during pregnancy in these women. There were, however, fewer symptoms reported by the lactose-maldigesting pregnant women.

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Section: Discussionsupporting

confidence: 90%

Lactose digestion in pregnant African-Americans

Paige

Witter

Bronner

et al. 2003

Public Health Nutr.

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“…If the results of this study could be extrapolated to the entire population of LI individuals, LI would not represent an appreciable clinical problem, provided that lactose was routinely ingested in divided doses with meals. Unfortunately, the findings of other authors indicate that much lower doses of lactose may cause gastrointestinal distress in people with LM, even if served in divided doses during the day (12-34 g) [24][25][26]. In the present study, the load of 400 ml of milk, kefir and yogurt served as a single dose without a meal provoked clinical symptoms in all of the examined subjects.…”

Section: Wyniki Wodorowo-metanowego Testu Oddechowego Po Spożyciu 4contrasting

confidence: 63%

Tolerance of different dairy products in subjects with symptomatic lactose malabsorption due to adult type hypolactasia

Mądry¹,

Krasińska²,

Woźniewicz³

et al. 2011

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“…Small amounts of lactose in portions of 4 to 8 oz spaced throughout the day and consumed with other foods may be tolerated with no symptoms. [47][48][49][50][51] Some children are able to drink 1 to 2 glasses of milk each day without difficulty but cannot tolerate more without developing symptoms. 14 Many lactose-intolerant individuals who are intolerant of milk can tolerate milk chocolate 52 and/or yogurt (plain better than flavored), because the bacteria in the yogurt partially digest the lactose into glucose and galactose before consumption.…”

Section: Managementmentioning

confidence: 99%

Lactose Intolerance in Infants, Children, and Adolescents

Heyman¹

2006

Pediatrics

460

348

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The American Academy of Pediatrics Committee on Nutrition presents an updated review of lactose intolerance in infants, children, and adolescents. Differences between primary, secondary, congenital, and developmental lactase deficiency that may result in lactose intolerance are discussed. Children with suspected lactose intolerance can be assessed clinically by dietary lactose elimination or by tests including noninvasive hydrogen breath testing or invasive intestinal biopsy determination of lactase (and other disaccharidase) concentrations. Treatment consists of use of lactase-treated dairy products or oral lactase supplementation, limitation of lactose-containing foods, or dairy elimination. The American Academy of Pediatrics supports use of dairy foods as an important source of calcium for bone mineral health and of other nutrients that facilitate growth in children and adolescents. If dairy products are eliminated, other dietary sources of calcium or calcium supplements need to be provided. INTRODUCTIONSIGNIFICANT CHANGES IN our knowledge and approach toward lactose intolerance have occurred over the past quarter century, since the first statement on lactose intolerance was published by the American Academy of Pediatrics Committee on Nutrition. 1 Lactose ingestion in certain susceptible individuals can cause abdominal symptoms that are variable and can be treated with dietary restriction or enzyme replacement, depending on the amount of lactose consumed and the degree of lactase deficiency. Pediatricians and other pediatric care providers should maintain awareness of the benefits and controversies related to the consumption of dietary milk products and milk-based infant formula. The lactose content of milk often influences, correctly or not, the ultimate decision about the use or continuation of milk in the diet. Milk and dairy-product avoidance has a negative effect on calcium and vitamin D intake in infants, children, and adolescents. Other nutrients such as protein make dairy products an important source of nutrition for growing children. This revised statement will update the initial statement of 1978 while incorporating changes from the 1990 supplement 2 and current state-of-theart relating to lactose intolerance. Recommendations regarding dietary calcium have been updated recently. 3 Lactose, a disaccharide that comprises the monosaccharides glucose and galactose, is the primary carbohydrate found exclusively in mammalian milk. Absorption of lactose requires lactase activity in the small intestinal brush border to split the bond linking the 2 monosaccharides. A ␤-galactosidase termed "lactase-phlorizin hydrolase" (lactase) accounts for most of the lactase activity in the intestinal

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Adaptation of lactose maldigesters to continued milk intakes

Cited by 83 publications

References 23 publications

Lactose digestion in pregnant African-Americans

Lactose digestion in pregnant African-Americans

Tolerance of different dairy products in subjects with symptomatic lactose malabsorption due to adult type hypolactasia

Lactose Intolerance in Infants, Children, and Adolescents

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