In the last decade, the society already regenerated their cognition by collective consciousness that leads humanity to moral attitudes and in a responsible manner upon global concerns. Likewise, as in various industries, the designers also have set up a sensitive approach through sustainability and empowerment. The new generation designers are the current change-makers that are shaping the future. For enhancing design innovation, current technology augments the creativity along with diversity and eligibility of applied techniques, and it enables the designer to work interdisciplinary. Any context or inspiration that stands in the edges of creativity is not out of the realm of possibility, only if it covers up social, environmental, or cultural concerns in harmony. To achieve distinctive results, the empirical approaches of design should be encouraged for solution-oriented and revolutionary projects. Therefore, this chapter discusses in-depth why and how designers should align with the integrity of art, engineering, science, technology, and sociology for holistic design-thinking.