Adaptive grip force is modulated by subthalamic beta activity in Parkinson's disease patients

Imbach, Lukas L.; Baumann‐Vogel, Heide; Baumann, Christian; Sürücü, Oǧuzkan; Hermsdörfer, Joachim; Sarnthein, Johannes

doi:10.1016/j.nicl.2015.09.010

Cited by 12 publications

(6 citation statements)

References 34 publications

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“…Beta power was also found to be decreased with increased task complexity just prior to movement (24). Imbach et al demonstrated beta band desynchronization during the execution of two different motor tasks (grip vs press) when assessing the event related potential 250 ms prior to and after the task (11). Furthermore, Fischer et al recently demonstrated a reduction in beta power during imagined levels of grip strength when assessed over a four second epoch (7).…”

Section: Discussionmentioning

confidence: 99%

Analysis of Movement-Related Beta Oscillations in the Off-Medication State During Subthalamic Nucleus Deep Brain Stimulation Surgery

Kochanski¹,

Shils

Metman

et al. 2019

Journal of Clinical Neurophysiology

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Introduction Local field potential (LFP) recordings from deep brain stimulator (DBS) leads provide insight into the pathophysiology of Parkinson’s disease (PD). We recorded LFP activity from DBS leads within the subthalamic nucleus (STN) in PD patients undergoing DBS surgery in order to identify reproducible pathophysiological signatures of the disease. Methods LFPs were recorded in 11 hemispheres from PD patients undergoing STN-DBS. Bipolar recordings were performed off medication for 2 minutes at rest and another 2 minutes with continuous repetitive opening-closing of the contralateral hand. Spectral analysis and bicoherence were performed and compared between the two testing conditions. Results In all hemispheres, predominance of the beta band frequency (13–30 Hz) was observed at rest and during movement. Beta peak energy was significantly (p<0.05) increased during movement compared to rest in 6 of 10 hemispheres. Significant beta bicoherence was observed at rest and during movement in 5 of 10 hemispheres. The most robust LFP recordings were observed at the DBS contact(s) independently chosen for programming in 9 of the 10 hemispheres. Conclusions In PD patients, beta activity that increases with repetitive movement may be a signature of the ‘off’ medication state. These findings provide new data on beta oscillatory activity during the Parkinsonian ‘off’ state that may help further define the LFP signatures of PD.

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Section: Discussionmentioning

confidence: 99%

Analysis of Movement-Related Beta Oscillations in the Off-Medication State During Subthalamic Nucleus Deep Brain Stimulation Surgery

Kochanski¹,

Shils

Metman

et al. 2019

Journal of Clinical Neurophysiology

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“…As control tasks, all patients performed several self-initiated movements during wakefulness (repetitive self-paced shaking and pressing movements) measured by an inertial measurement unit as described previously (Imbach et al, 2015). As a second control experiment, we identified movements during NREM sleep.…”

Section: Methodsmentioning

confidence: 99%

Electrophysiological Evidence for Alternative Motor Networks in REM Sleep Behavior Disorder

Hackius¹,

Werth²,

Sürücü

et al. 2016

J. Neurosci.

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Patients with Parkinson's disease (PD) and REM sleep behavior disorder (RBD) show mostly unimpaired motor behavior during REM sleep, which contrasts strongly to coexistent nocturnal bradykinesia. The reason for this sudden amelioration of motor control in REM sleep is unknown, however. We set out to determine whether movements during REM sleep are processed by different motor networks than movements in the waking state. We recorded local field potentials in the subthalamic nucleus (STN) and scalp EEG (modified 10/20 montage) during sleep in humans with PD and RBD. Time-locked event-related ␤ band oscillations were calculated during movements in REM sleep compared with movements in the waking state and during NREM sleep. Spectral analysis of STN local field potentials revealed elevated ␤ power during REM sleep compared with NREM sleep and ␤ power in REM sleep reached levels similar as in the waking state. Event-related analysis showed time-locked ␤ desynchronization during WAKE movements. In contrast, we found significantly elevated ␤ activity before and during movements in REM sleep and NREM sleep. Corticosubthalamic coherence was reduced during REM and NREM movements. We conclude that sleep-related movements are not processed by the same corticobasal ganglia network as movements in the waking state. Therefore, the well-known seemingly normal motor performance during RBD in PD patients might be generated by activating alternative motor networks for movement initiation. These findings support the hypothesis that pathological movement-inhibiting basal ganglia networks in PD patients are bypassed during sleep.

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“…Furthermore, the two main therapeutic strategies, the administration of l -Dopa 3 , 9 and high-frequency DBS 8 , 10 , both lead to a suppression of beta-synchronicity in the STN. Beta-oscillations show fast and movement-dependent modulation over time 11 , 12 and have been proposed as a feedback signal to control the delivery of DBS in a closed-loop system 13 .…”

Section: Introductionmentioning

confidence: 99%

Deep brain electrical neurofeedback allows Parkinson patients to control pathological oscillations and quicken movements

Bichsel

Stieglitz

Oertel

et al. 2021

Sci Rep

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Parkinsonian motor symptoms are linked to pathologically increased beta-oscillations in the basal ganglia. While pharmacological treatment and deep brain stimulation (DBS) reduce these pathological oscillations concomitantly with improving motor performance, we set out to explore neurofeedback as an endogenous modulatory method. We implemented real-time processing of pathological subthalamic beta oscillations through implanted DBS electrodes to provide deep brain electrical neurofeedback. Patients volitionally controlled ongoing beta-oscillatory activity by visual neurofeedback within minutes of training. During a single one-hour training session, the reduction of beta-oscillatory activity became gradually stronger and we observed improved motor performance. Lastly, endogenous control over deep brain activity was possible even after removing visual neurofeedback, suggesting that neurofeedback-acquired strategies were retained in the short-term. Moreover, we observed motor improvement when the learnt mental strategies were applied 2 days later without neurofeedback. Further training of deep brain neurofeedback might provide therapeutic benefits for Parkinson patients by improving symptom control using strategies optimized through neurofeedback.

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Adaptive grip force is modulated by subthalamic beta activity in Parkinson's disease patients

Cited by 12 publications

References 34 publications

Analysis of Movement-Related Beta Oscillations in the Off-Medication State During Subthalamic Nucleus Deep Brain Stimulation Surgery

Analysis of Movement-Related Beta Oscillations in the Off-Medication State During Subthalamic Nucleus Deep Brain Stimulation Surgery

Electrophysiological Evidence for Alternative Motor Networks in REM Sleep Behavior Disorder

Deep brain electrical neurofeedback allows Parkinson patients to control pathological oscillations and quicken movements

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