In the last decades, several studies demonstrate how the integration of manufacturing and supply chain in the early design phase brings significant advantages to industries. Within the European Project (AGILE 4.0, 2022), a value‐driven methodology concurrently coupling design, manufacturing and supply chain has been developed. This study aims at addressing a new challenge: the identification of non‐dominated solutions simultaneously accounting for manufacturing, design and supply chain variables. For this purpose, an optimization design campaign has been addressed in this research activity and the main results are‐here presented.