Adaptive regulation of wall shear stress optimizing vascular tree function

Kamiya, Akira; Bukhari, Razaq; Togawa, Tatsuo

doi:10.1016/s0092-8240(84)80038-5

Cited by 171 publications

(128 citation statements)

References 19 publications

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“…On the other hand, some data suggest that quantitative rules may exist for some systems, at least within the constraints of natural biological variability. Consider, for instance, the relatively narrow range of fluid shear stress exerted on the walls of arteries of widely varying size (Kamiya et al, 1984). There also is evidence of a quantitative theory for bone development (Carter, 1987).…”

Section: Primary Ingredients Of the Hyper-restoration Hypothesismentioning

confidence: 99%

Theoretical study of Beloussov’s hyper-restoration hypothesis for mechanical regulation of morphogenesis

Taber

2007

Biomech Model Mechanobiol

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Computational models were used to explore the idea that morphogenesis is regulated, in part, by feedback from mechanical stress according to Beloussov's Hyper-restoration (HR) Hypothesis. According to this hypothesis, active tissue responses to stress perturbations restore, but overshoot, the original (target) stress. To capture this behavior, the rate of growth or contraction is assumed to depend on the difference between the current and target stresses. Stress overshoot is obtained by letting the target stress change at a rate proportional to the same stress difference. The feasibility of the HR Hypothesis is illustrated by models for stretching of epithelia, cylindrical bending of plates, invagination of cylindrical and spherical shells, and early amphibian development. In each case, an initial perturbation leads to an active mechanical response that changes the form of the tissue. The results show that some morphogenetic processes can be entirely self-driven by HR responses once they are initiated (possibly by genetic activity). Other processes, however, may require secondary mechanisms or perturbations to proceed to completion.

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Section: Primary Ingredients Of the Hyper-restoration Hypothesismentioning

confidence: 99%

Theoretical study of Beloussov’s hyper-restoration hypothesis for mechanical regulation of morphogenesis

Taber

2007

Biomech Model Mechanobiol

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“…The frictional stress observed in this work was in the order of 10100 Pa even for the TGF- 1 -treated sample, which is considerably higher than the shear stress exerted on the wall of the blood vessels of the in vivo system that has a value of 2 Pa [20]. The high frictional I-treated samples, respectively).…”

Section: Discussion Of Ecs Gel Friction In Vitro Using Hydrogel Lubrimentioning

confidence: 54%

“…In the in vivo system, the shear stress exerted on the wall of the capillary was found about 2 Pa [20]. If we assume that this dynamic shear stress is contributed by the viscose drag of the liquid entrapped at the RBC-EC interface with an average thickness h and in the glycocalyx matrix with a permeability gel K on the ECs surface, the apparent lubricating thickness…”

Section: Discussion Of Rbc Friction In Vivo Using Hydrogel Lubricatiomentioning

confidence: 99%

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Study on the Sliding Friction of Endothelial Cells Cultured on Hydrogel and the Role of Glycocalyx on Friction Reduction

et al. 2010

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In this study, we investigated the sliding friction of human umbilical vein endothelial cell (HUVEC) monolayer cultured on poly(sodium p-styrene sulfonate) (PNaSS) gel, intending to elucidate the role of the glycocalyx on the surface of endothelial cell (EC) in friction reduction.Three sets of HUVEC monolayers were investigated: 1) as-cultured HUVEC monolayer, 2) HUVEC monolayer treated by transforming growth factor  1 (TGF- 1 ), which increased glycocalyx by 148%, 3) HUVEC monolayer treated by heparinase I, which reduced glycocalyx by 57%, both were compared with that of the as prepared one. When being slid on flat glass surface, the frictional stress of HUVEC monolayer decreased in the order of heparinase I-treated > as-cultured > TGF- 1 -treated samples. The results suggested that glycocalyx may play a role in reducing the friction of endothelial cell monolayer.

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“…Data on potential differences in homeostatic wall shear stress across species are lacking, hence the current target values of stress were chosen to reasonably represent existing experiments on veins independent of species [24,27,49]. Experiments looking at venous and arterial markers suggest that the venous identity is lost but an arterial identity is not fully gained during a vein graft adaptation [50].…”

Section: Discussionmentioning

confidence: 99%

Computational Simulation of the Adaptive Capacity of Vein Grafts in Response to Increased Pressure

Ramachandra

Sankaran

Humphrey

et al. 2015

Journal of Biomechanical Engineering

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Vein maladaptation, leading to poor long-term patency, is a serious clinical problem in patients receiving coronary artery bypass grafts (CABGs) or undergoing related clinical procedures that subject veins to elevated blood flow and pressure. We propose a computational model of venous adaptation to altered pressure based on a constrained mixture theory of growth and remodeling (G&R). We identify constitutive parameters that optimally match biaxial data from a mouse vena cava, then numerically subject the vein to altered pressure conditions and quantify the extent of adaptation for a biologically reasonable set of bounds for G&R parameters. We identify conditions under which a vein graft can adapt optimally and explore physiological constraints that lead to maladaptation. Finally, we test the hypothesis that a gradual, rather than a step, change in pressure will reduce maladaptation. Optimization is used to accelerate parameter identification and numerically evaluate hypotheses of vein remodeling.

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Adaptive regulation of wall shear stress optimizing vascular tree function

Cited by 171 publications

References 19 publications

Theoretical study of Beloussov’s hyper-restoration hypothesis for mechanical regulation of morphogenesis

Theoretical study of Beloussov’s hyper-restoration hypothesis for mechanical regulation of morphogenesis

Study on the Sliding Friction of Endothelial Cells Cultured on Hydrogel and the Role of Glycocalyx on Friction Reduction

Computational Simulation of the Adaptive Capacity of Vein Grafts in Response to Increased Pressure

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