Adaptive responses to fescue toxicosis under thermoneutral and heat stress conditions

Kishore, D. K.; Eichen, P. A.; Spiers, Donald E.

doi:10.1016/j.jtherbio.2011.12.014

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…Our approach when deciding on a proper dose to generate the fescue toxicosis condition has always been to use the most recent amount to elicit a response. In rat studies, the EV level is ~165 μg EV • kg -1 BW • d -1 , using ground seed (Kishore et al, 2012). It is our conclusion that the relative dose is more important than the absolute one.…”

Section: Treatmentsmentioning

confidence: 80%

Use of different levels of ground endophyte-infected tall fescue seed during heat stress to separate characteristics of fescue toxicosis1

Spiers

Wax

Eichen

et al. 2012

Journal of Animal Science

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Studies of fescue toxicosis using whole seed diets show reduced feed intake and thermoregulatory ability, but much of the seed passes undigested through the animal. Cattle were fed ground tall fescue seed at different levels to potentially facilitate digestion and absorption of toxins and identify toxin sensitivity for major characteristics of the condition [i.e., hyperthermia, reduced feed intake (FI), reduced blood prolactin]. Steers (n = 18; 350 kg BW) were housed in the Brody Climatology Laboratory at thermoneutrality (TN; 19°C) and randomly assigned to daily diet treatments with either ground endophyte-infected [E+; low and high doses at 20 and 40 μg ergovaline/(kg BW/d), respectively] or endophyte-free [E-; control at 0 μg ergovaline/(kg BW/d)] tall fescue seed. After 12 d at TN, animals received 2 d of transition to heat stress (HS; 36°C daytime, 25°C nighttime) and maintained for 14 more days. Cattle were fed twice daily at 0800 and 1600 h, with water ad libitum. Feed intake was measured at 0700 h, with skin and rectal temperatures, and respiration rate at 0600, 1100, 1600, and 2100 h. Blood was sampled on selected days for prolactin and leptin determinations. Steers fed ground E+ diet decreased (P ≤ 0.0001) FI below controls at TN, with no dose effect. Maximum FI reduction with E+ treatment was 25% at TN, with an additional 46% decrease during HS (P ≤ 0.05). By the end of HS, E+ FI increased (P > 0.05) to that of E-, suggesting recovery. Prolactin was reduced (P ≤ 0.05) in high E+ cattle below controls at study end. Leptin blood concentrations were unaffected by E+ treatment (P > 0.05) but was reduced (P ≤ 0.05) by the end of HS. Pattern of rectal temperature response to HS showed a more rapid initial increase and decline for both E+ groups compared with controls (P ≤ 0.05). Skin temperature was the only variable that identified E+ dose differences. Although there were no treatment differences at TN, skin temperature was lower (P ≤ 0.05) for high E+ steers compared with controls during HS when air temperature was reduced each day. In general, FI was more responsive to E+ toxins than body temperature or blood prolactin, declining even at TN and exhibiting dynamic activity during HS. Although body temperature response to E+ toxins appears to stabilize during HS, this is misleading as rapid change in air temperature exposes effects on skin temperature.

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Section: Treatmentsmentioning

confidence: 80%

Use of different levels of ground endophyte-infected tall fescue seed during heat stress to separate characteristics of fescue toxicosis1

Spiers

Wax

Eichen

et al. 2012

Journal of Animal Science

View full text Add to dashboard Cite

show abstract

Adaptive responses to fescue toxicosis under thermoneutral and heat stress conditions

Cited by 2 publications

References 26 publications

Use of different levels of ground endophyte-infected tall fescue seed during heat stress to separate characteristics of fescue toxicosis1

Use of different levels of ground endophyte-infected tall fescue seed during heat stress to separate characteristics of fescue toxicosis1

Utilizing laboratory and field studies to determine physiological responses of cattle to multiple environmental stressors

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