Added diagnostic value of respiratory-gated 4D 18F–FDG PET/CT in the detection of liver lesions: a multicenter study

Abstract

Respiratory-gated PET/CT technique is a valuable clinical tool in diagnosing liver lesions, reducing 3D undetermined findings, improving diagnostic accuracy, and confidence in reporting. 4D-PET/CT also improved the quantification of SUVmax of liver lesions.

Comparison of two elastic motion correction approaches for whole-body PET/CT: motion deblurring vs gate-to-gate motion correction

“…Given the high spatial resolution of modern whole-body PET systems of 4-5 mm full width at half maximum (FWHM) [1,5], respiratory motion is not only affecting tumour PET imaging, but has also a negative impact on quantitative imaging of organs like the liver, kidneys, or spleen [6]. To overcome this, different motion correction (MC) approaches have been proposed before which compared for example gated (amplitude-based or phase-based) to non-gated reconstructions or optimal respiratory-gating 4D PET/CT to 3D PET/CT [7][8][9][10][11].…”

Evaluation of a Novel Elastic Respiratory Motion Correction Algorithm on Quantification and Image Quality in Abdominothoracic PET/CT

“…3 min per bed position, which can result in degraded PET image quality due to respiratory motion, particularly for tumors in the lower thorax and upper abdomen (1)(2)(3). This degradation potentially results in decreased measurements of activity concentration, overestimated measured metabolic volume, and decreased lesion detectability, all of which could negatively affect patient management.…”

Evaluation of Hybrid PET/MRI for Gross Tumor Volume (GTV) Delineation in Liver Cancer Radiotherapy

“…Furthermore, during the process of PET/MRI image acquisition, images will be affected by motion artifacts due to breath-hold, which may lead to the underestimation of lesion uptake and to the possibility of missing small lesions [38]. During normal respiratory movement, organs can undergo displacements of up to 2 cm [18,19], and the liver is particularly vulnerable to respiratory motion.…”

“…Considering that liver SBRT is a very precise treatment technique in regard to the tissue exposed to radiation toxicity, any procedure designed to make radiotherapy planning more precise is of particular interest. Respiratory-gated PET (4D-PET) has been proposed as one of the approaches to address these issues [38]. Compared with nongated PET, respiratory-gated PET can improve the image quality and lesion detectability of liver targets and assess the target volumes with increased accuracy [39].…”