Added value of amide proton transfer imaging to conventional and perfusion MR imaging for evaluating the treatment response of newly diagnosed glioblastoma

Park, Kye Jin; Kim, Ho Sung; Park, Ji Eun; Shim, Woo Hyun; Kim, Sang Joon; Smith, Seth A.

doi:10.1007/s00330-016-4261-2

Cited by 78 publications

(71 citation statements)

References 26 publications

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“…Several clinical studies have now confirmed the ability of APTw imaging to differentiate recurrent tumor from treatment effects . These early results demonstrate the potential of APTw imaging in neuro‐oncology, providing a noninvasive imaging biomarker for distinguishing active tumor from radiation necrosis.…”

Section: Current Applicationsmentioning

confidence: 72%

APT‐weighted MRI: Techniques, current neuro applications, and challenging issues

Zhou

Heo

Knutsson

et al. 2019

Magnetic Resonance Imaging

255

329

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Amide proton transfer‐weighted (APTw) imaging is a molecular MRI technique that generates image contrast based predominantly on the amide protons in mobile cellular proteins and peptides that are endogenous in tissue. This technique, the most studied type of chemical exchange saturation transfer imaging, has been used successfully for imaging of protein content and pH, the latter being possible due to the strong dependence of the amide proton exchange rate on pH. In this article we briefly review the basic principles and recent technical advances of APTw imaging, which is showing promise clinically, especially for characterizing brain tumors and distinguishing recurrent tumor from treatment effects. Early applications of this approach to stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and traumatic brain injury are also illustrated. Finally, we outline the technical challenges for clinical APT‐based imaging and discuss several controversies regarding the origin of APTw imaging signals in vivo. Level of Evidence: 3 Technical Efficacy Stage: 3 J. Magn. Reson. Imaging 2019;50:347–364.

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Section: Current Applicationsmentioning

confidence: 72%

APT‐weighted MRI: Techniques, current neuro applications, and challenging issues

Zhou

Heo

Knutsson

et al. 2019

Magnetic Resonance Imaging

255

329

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“…APT MRI contrast has shown a positive correlation with tumor grade as assessed with histopathology . Treatment has been shown to reduce APT MRI contrast . Correspondingly, APT MRI generated lower contrast in pseudoprogression from posttreatment inflammation compared to recurrent glioma .…”

Section: Amide Proton Transfermentioning

confidence: 99%

Clinical applications of chemical exchange saturation transfer (CEST) MRI

Jones

Pollard

Pagel

2017

Magnetic Resonance Imaging

228

246

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Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) has been developed and employed in multiple clinical imaging research centers worldwide. Selective radiofrequency (RF) saturation pulses with standard 2D and 3D MRI acquisition schemes are now routinely performed, and CEST MRI can produce semiquantitative results using magnetization transfer ratio asymmetry (MTRasym) analysis while accounting for B0 inhomogeneity. Faster clinical CEST MRI acquisition methods and more quantitative acquisition and analysis routines are under development. Endogenous biomolecules with amide, amine, and hydroxyl groups have been detected during clinical CEST MRI studies, and exogenous CEST agents have also been administered to patients. These CEST MRI tools show promise for contributing to assessments of cerebral ischemia, neurological disorders, lymphedema, osteoarthritis, muscle physiology, and solid tumors. This review summarizes the salient features of clinical CEST MRI protocols and critically evaluates the utility of CEST MRI for these clinical imaging applications. Level of Evidence: 5 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018;47:11–27.

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“…3,[11][12][13][14][15][16][17][18] However, details of the relationships between APT imaging and other clinical imaging parameters of malignancy have yet to be fully elucidated. This study confirmed that APT imaging can be used for grading glial tumors, with a diagnostic accuracy comparable with that of other imaging biomarkers derived from DWI and FDG-PET.…”

Section: Additive Value Of Apt Imaging To Dwi For Glioma Gradingmentioning

confidence: 99%

“…3,[10][11][12][13][14][15][16] Some reports have shown that the APT asymmetry value is useful in tumor grading, allowing differentiation of pseudoprogression from recurrence 17 and the assessment of treatment response. 18,19 However, the relationship between APT and other quantitative imaging values has yet to be investigated.…”

mentioning

confidence: 99%

Addition of Amide Proton Transfer Imaging to FDG-PET/CT Improves Diagnostic Accuracy in Glioma Grading: A Preliminary Study Using the Continuous Net Reclassification Analysis

Sakata¹,

Okada²,

Yamamoto

et al. 2018

AJNR Am J Neuroradiol

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Added value of amide proton transfer imaging to conventional and perfusion MR imaging for evaluating the treatment response of newly diagnosed glioblastoma

Cited by 78 publications

References 26 publications

APT‐weighted MRI: Techniques, current neuro applications, and challenging issues

APT‐weighted MRI: Techniques, current neuro applications, and challenging issues

Clinical applications of chemical exchange saturation transfer (CEST) MRI

Addition of Amide Proton Transfer Imaging to FDG-PET/CT Improves Diagnostic Accuracy in Glioma Grading: A Preliminary Study Using the Continuous Net Reclassification Analysis

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