Addition of MgO nanoparticles and plasma surface treatment of three-dimensional printed polycaprolactone/hydroxyapatite scaffolds for improving bone regeneration

Roh, Hee-Sang; Chang‐Min, Lee; Hwang, Young-Hyoun; Kook, Min-Suk; Yang, Seong-Won; Lee, Donghun; Kim, Byung–Hoon

doi:10.1016/j.msec.2016.12.054

Cited by 103 publications

(81 citation statements)

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“…Histomorphometrically, it showed no specific inflammatory reaction around the PCL block with or without 10 wt% β‐TCP. PCL, a biocompatible polymer, is known as a safe material in many other studies, and this study also showed biocompatibility of this material in the rabbit in vivo . When pure PCL or PCL mixed with β‐TCP were used, there was less new bone formation than the control group, but there was no statistically significant difference except PCL/β‐TCP group at 8 weeks.…”

Section: Discussionsupporting

confidence: 71%

“…Therefore, in order to improve the hydrophobic properties of polymer, it could be mixed and coated with ceramic particles, or plasma treated on the surface . In the previous in vitro studies, the addition of magnesium oxide, hydroxyapatite or β‐TCP followed by oxygen and nitrogen plasma treatment enhanced the adhesion, proliferation, and differentiation of preosteoblast cells in the PCL scaffolds . Surface morphology and chemical properties of the PCL scaffold could affect the preosteoblast cells .…”

Section: Discussionmentioning

confidence: 99%

“…One of the ways to overcome these problems is to add ceramics such as β‐tricalcium phosphate (β‐TCP) to the PCL to increase hydrophilicity, osteoconductivity, and the degradation rate to promote bone formation . Many previous studies showed that the ceramic addition to these polymers enhanced the bone formation as well as the adhesion and proliferation of preosteoblast cells …”

Section: Introductionmentioning

confidence: 99%

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3D‐printed polycaprolactone scaffold mixed with β‐tricalcium phosphate as a bone regenerative material in rabbit calvarial defects

et al. 2018

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Defect-specific bone regeneration using 3-dimensional (3D) printing of block bone has been developed. Polycaprolactone (PCL) is biocompatible polymer that can be used as 3D scaffold. The aim of this study is to assess the biocompatibility and osteogenic efficacy of 3D printed PCL scaffold and to evaluate the effectiveness of β-tricalcium phosphate (β-TCP) addition in PCL scaffold. In this work, four circular defects (diameter: 8 mm) in rabbit calvarium were randomly assigned to (1) negative control (control), (2) PCL block (PCL), (3) PCL mixed with 10 wt% β-TCP (PCL/β-TCP), and (4) PCL/β-TCP plus collagen membrane (PCL/β-TCP + M). Animals were euthanized at 2 (n = 5) and 8 weeks (n = 5). Results indicated that in micro-CT, PCL/β-TCP + M showed the highest total augmented volume and new bone volume at 8 weeks, but there was no significant difference among four groups. Histomorphometrically, PCL, PCL/β-TCP, and PCL/β-TCP + M showed the significantly higher total augmented area compared to the control. PCL/β-TCP + M showed the highest new bone area but not statistically higher than the control. New bone formation deep inside the scaffold was observed only in β-TCP added scaffold. PCL showed high biocompatibility with great volume maintenance. Addition of β-TCP to PCL seemed to increase hydrophilicity and osteoconductivity. Developments in 3D-printed PCL material are expected.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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3D‐printed polycaprolactone scaffold mixed with β‐tricalcium phosphate as a bone regenerative material in rabbit calvarial defects

et al. 2018

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“…Although most manufactured nanomaterials are dispersed readily when in contact with water, 144 there are some exceptions. For example, metallic nanotubes are not dispersed in water, even with the use of physical methods.…”

Section: Discussionmentioning

confidence: 99%

“…By adding MgONPs to polycaprolactone hydroxyapatite (PCL/Hap) composites, Roh et al reports enhanced adhesion, proliferation, and differentiation of preosteoblasts. 144 These results propose possible improvements to 3D-scaffolds for encouraging bone tissue regeneration.…”

mentioning

confidence: 84%

Antibacterial properties and toxicity from metallic nanomaterials

Vimbela¹,

Ngo²,

Fraze³

et al. 2017

IJN

530

334

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The era of antibiotic resistance is a cause of increasing concern as bacteria continue to develop adaptive countermeasures against current antibiotics at an alarming rate. In recent years, studies have reported nanoparticles as a promising alternative to antibacterial reagents because of their exhibited antibacterial activity in several biomedical applications, including drug and gene delivery, tissue engineering, and imaging. Moreover, nanomaterial research has led to reports of a possible relationship between the morphological characteristics of a nanomaterial and the magnitude of its delivered toxicity. However, conventional synthesis of nanoparticles requires harsh chemicals and costly energy consumption. Additionally, the exact relationship between toxicity and morphology of nanomaterials has not been well established. Here, we review the recent advancements in synthesis techniques for silver, gold, copper, titanium, zinc oxide, and magnesium oxide nanomaterials and composites, with a focus on the toxicity exhibited by nanomaterials of multidimensions. This article highlights the benefits of selecting each material or metal-based composite for certain applications while also addressing possible setbacks and the toxic effects of the nanomaterials on the environment.

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