Addition of tanshinone IIA to UW solution decreases skeletal muscle ischemia-reperfusion injury1

Wang, Honggang; Li, Zhiyong; Liu, Xiaolin

doi:10.1111/j.1745-7254.2006.00357.x

Cited by 13 publications

(7 citation statements)

References 27 publications

(28 reference statements)

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“…Wang et al, 2006;J.J. Liu et al, 2006), however, also concentrations of 3 g/mL in vitro or 0.05 to 0.2 g/mL in vivo were reported to protect cells from free radicals induced apoptosis (Meng et al, 2006;H.G. Wang et al, 2006).…”

Section: Discussionmentioning

confidence: 95%

The effect of the major components of Salvia Miltiorrhiza Bunge on bone marrow cells

Liu

Maitz

et al. 2007

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 95%

The effect of the major components of Salvia Miltiorrhiza Bunge on bone marrow cells

Liu

Maitz

et al. 2007

Journal of Ethnopharmacology

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“…11,12 Before induction of anaesthesia for the experiment, each rat was subjected to 12 h of fasting with unrestricted access to water. Rats were anaesthetized with 3% pentobarbital (40 mg/kg intraperitoneally) and then kept on a heated operating table to maintain core body temperature at 36.5 -37.5 ºC, monitored with a rectal temperature probe.…”

Section: Surgical Preparationmentioning

confidence: 99%

Effects of Simvastatin on Lung Injury Induced by Ischaemia–Reperfusion of the Hind Limbs in Rats

Sun

et al. 2007

J Int Med Res

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We investigated whether simvastatin reduces lung injury caused by ischaemia-reperfusion of the hind limbs in rats. The control group underwent dissection of bilateral femoral arteries; another group (I/R group) underwent ischaemia of bilateral hind limbs for 2 h followed by 3 h reperfusion; and two other groups were pretreated with 5 or 10 mg/kg per day simvastatin for 3 days and then underwent ischaemia-reperfusion. The control and I/R group rats received placebo (water) instead of simvastatin. The lungs of the I/R rats showed marked histopathological changes compared with the other groups. Lung tissue myeloperoxidase, malondialdehyde, neutrophil count and lung injury scores in both simvastatin groups were significantly lower than in the I/R group; 10 mg/kg per day simvastatin significantly reduced lung water content although 5 mg/kg per day did not. Expression of haem oxygenase-1 (HO-1) protein in lung tissue was significantly greater in the simvastatin groups than in the I/R group. Simvastatin protects against lung injury associated with lower extremity ischaemia-reperfusion by reduction of neutrophil aggregation and oxidative damage, and upregulation of HO-1 expression in the injured lung.

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“…Recent medical research has found more than 15 types of chemical structures extracted from DS, and tanshinone IIA was the main effective components of anti-oxidative activity (22), adjustment of the metabolism of blood lipids (23), improvement of rheology, body microcirculation and activity of fibrinolysis (24). Investigators have reported that tanshinone IIA displayed significant protective effects on I/R injury in skeletal muscle preservation (9). In this study, we found that tanshinone IIA down-regulated the quantity of MDA and up-regulated the activity of SOD in preserved renal tissues, which revealed the anti-oxidant activity of tanshinone IIA.…”

Section: Discussionmentioning

confidence: 99%

“…Extensive studies have proven that tanshinone IIA is one of the most abundant components of DS, exhibiting a variety of biochemical activities, including vasorelaxation, elimination of oxygen-derived free radicals, stabilization of vascular endothelial function and protection against I/R injury (8). Investigators have reported that tanshinone IIA improves the protective effects of University of Wisconsin (UW) solution for skeletal muscle preservation by inhibiting ICAM-1 expression and apoptosis (9). In this study, tanshinone IIA was added to the standard hypothermia preservation solution in order to investigate a possible protective effect of tanshinone IIA during hypothermic preservation and explore the possible mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of tanshinone IIA on rat kidneys during hypothermic preservation

Zhang

et al. 2011

Mol Med Report

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Abstract. Renal preservation is a universal problem since ischemia/reperfusion (I/R) injury remains an unresolved issue during the procedure of renal transplantation. Tanshinone IIA, one of the effective components of the traditional Chinese medicine Danshen, was reported to exhibit a variety of biochemical activities, including protection against I/R injury. Therefore, identifying the specific molecular pathway mediating tanshinone IIA protection of renal preservation would be of great value to the patients concerned. In this study, rats were divided into two groups and the kidneys were isolated and preserved in two solutions separately, one with Celsior solution and the other with tanshinone IIA additionally added to the Celsior solution. The superoxide dismutase (SOD) activity and the quantity of malonaldehyde (MDA) were measured, the expression of CHOP and caspase-12 were assessed by immunohistochemistry staining, and real-time quantitative reverse transcription-polymerase chain reaction analysis was performed after 0, 24 and 48 h of preservation. A significant increase in the activities of SOD and a decrease in the quantity of MDA were observed in the kidneys preserved with tanshinone IIA at 24 and 48 h (P<0.01). The expression of CHOP and caspase-12 was lower in the kidneys preserved with tanshinone IIA at 24 and 48 h than that in the kidneys preserved with Celsior solution alone (P<0.05). The results suggest that the supplementation of tanshinone IIA in standard Celsior solution may significantly improve long-term kidney preservation. Attenuating oxidative stress injury and decreasing endoplasmic reticulum (ER) stress-mediated apoptosis may play a role in the protection of kidney hypothermic preservation.

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Addition of tanshinone IIA to UW solution decreases skeletal muscle ischemia-reperfusion injury1

Abstract: UW plus tanshinone IIA increased protection against I/R injury, suggesting that tanshinone IIA has clinical value.

Cited by 13 publications

References 27 publications

The effect of the major components of Salvia Miltiorrhiza Bunge on bone marrow cells

The effect of the major components of Salvia Miltiorrhiza Bunge on bone marrow cells

Effects of Simvastatin on Lung Injury Induced by Ischaemia–Reperfusion of the Hind Limbs in Rats

Protective effect of tanshinone IIA on rat kidneys during hypothermic preservation

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