Additional benefit of hemostatic sealant in preservation of ovarian reserve during laparoscopic ovarian cystectomy: a multi-center, randomized controlled trial

Song, Taejong; Lee, San Hui; Kim, Woo Young

doi:10.1093/humrep/deu125

Cited by 56 publications

(56 citation statements)

References 28 publications

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“…Inclusion criteria consisted of women aged 19-45 with regular menstrual periods (21-35 days), a maximal cyst diameter between 3 and 10 cm, and appropriate medical status for laparoscopic surgery (American Society of Anesthesiologists Physical Status classification 1 or 2). Exclusion criteria were evidence of any other endocrine disorder such as diabetes mellitus, thyroid dysfunction, hyperprolactinemia, or Cushing's syndrome; postmenopausal status; preoperative serum AMH < 1.0 ng/mL; pregnancy; or the use of any hormonal treatment in the three months before surgery [9].…”

Section: Methodsmentioning

confidence: 99%

“…However, the efficacies of such methods remain somewhat controversial. We recently reported the ability of a topical hemostatic collagen, FloSeal 1 (Baxter, Zurich, Switzerland), to preserve ovarian reserve [9]. Although FloSeal is easy to handle for laparoscopic use, cases of granuloma formation after the use of FloSeal have been reported [10,11].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of hemostatic sealants on ovarian reserve during laparoscopic ovarian cystectomy

Kang

Kim

Lee

et al. 2015

European Journal of Obstetrics & Gynecology and Reproductiv

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of hemostatic sealants on ovarian reserve during laparoscopic ovarian cystectomy

Kang

Kim

Lee

et al. 2015

European Journal of Obstetrics & Gynecology and Reproductiv

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“…14 Finally, 2 more studies were excluded because they compared bipolar electrocoagulation with hemostatic sealant. 15,16 Included studies Eight studies were finally included in our systematic review, which recruited 545 women. [17][18][19][20][21][22][23][24] Among them, 266 women (48.8%) were treated with bipolar electrocoagulation after the excision of the ovarian cyst, whereas the remaining 279 (51.2%) were treated with hemostatic suturing.…”

Section: Excluded Studiesmentioning

confidence: 99%

The effect of bipolar electrocoagulation during ovarian cystectomy on ovarian reserve: a systematic review

Pergialiotis

Prodromidou

Frountzas

et al. 2015

American Journal of Obstetrics and Gynecology

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The aim of the present systematic review was to study the effect of bipolar electrocoagulation during ovarian cystectomy on ovarian reserve. We searched Medline (1966-2015), Scopus (2004-2015), ClinicalTrials.gov (2008-2015), and Cochrane Central Register (CENTRAL) databases along with reference lists of electronically retrieved studies. The levels of antimullerian hormone (AMH) and antral follicle count (AFC) at 1, 3, 6, and 12 months following the excision of the benign ovarian cyst were defined as primary outcomes. Eight studies were finally included in our systematic review, which recruited 545 women. A metaanalysis was precluded because of significant heterogeneity in the methodological characteristics of the included studies. Data from the included studies suggest that the use of bipolar coagulation compared with ovarian sutures seems to result in significantly lower AMH and AFC during the first 3 months following the excision of the ovarian cyst. Two studies reported that this effect seems to persist at 6 and 12 months postoperatively. Bipolar electrodiathermy seems to be accompanied by increased damage to ovarian reserve, which is indicated by the lower levels of AMH and AFC. However, definitive results are precluded because of the significant heterogeneity of included studies and the potential bias.

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“…The primary outcome measure was change in the ovarian reserve, as determined by the rate of decline in serum AMH level from before surgery to 3 months post-surgery using the following formula [14] : decline rate (%) = 100 × (preoperative AMH levelpostoperative AMH level)/preoperative AMH level. The serum AMH concentrations were measured by an enzyme immunoassay kit according to the manufacturer's instructions (Immunotech, Beckman Coulter, Marseille, France).…”

Section: Outcome Measuresmentioning

confidence: 99%

Opportunistic Salpingectomy Does Not Affect Ovarian Reserve or Surgical Outcomes in Patients Undergoing Laparoscopic Myomectomy

Song

Lee²,

Kim³

et al. 2016

Gynecol Obstet Invest

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Objective: To determine whether opportunistic salpingectomy in patients undergoing laparoscopic myomectomy has any deleterious effects on ovarian reserve and surgical risk. Study Design: We performed a retrospective review of patients who had no desire for future child bearing and who were undergoing laparoscopic myomectomy for symptomatic myomas at 4 institutions. Among them, 41 patients concurrently underwent opportunistic salpingectomy (the opportunistic salpingectomy group) and 65 patients did not undergo salpingectomy at the time of laparoscopic myomectomy (the no-salpingectomy group). The primary and secondary outcome measures were change of ovarian reserve determined by the rate of decline in the anti-Müllerian hormone (AMH) level from before surgery to 3 months post-surgery, and surgical outcomes. Results: Baseline characteristics were similar between groups. There were also no differences in surgical outcomes, such as operative time, operative bleeding, hospital stay, or complications between groups. The decline rate in AMH was 18.6% (interquartile range (IQR) 2.6-46.8%) in the opportunistic salpingectomy group and 10.4% (IQR 2.6-46.8%) in the no-salpingectomy group, with no significant difference between groups (p = 0.593). Conclusion: Opportunistic salpingectomy at the time of laparoscopic myomectomy was not associated with negative effects on ovarian reserve or increased surgical risk.

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Additional benefit of hemostatic sealant in preservation of ovarian reserve during laparoscopic ovarian cystectomy: a multi-center, randomized controlled trial

Abstract: www.clinicaltrials.gov, no. NCT01857466.

Cited by 56 publications

References 28 publications

Comparison of hemostatic sealants on ovarian reserve during laparoscopic ovarian cystectomy

Comparison of hemostatic sealants on ovarian reserve during laparoscopic ovarian cystectomy

The effect of bipolar electrocoagulation during ovarian cystectomy on ovarian reserve: a systematic review

Opportunistic Salpingectomy Does Not Affect Ovarian Reserve or Surgical Outcomes in Patients Undergoing Laparoscopic Myomectomy

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