2019
DOI: 10.1016/j.jsams.2019.05.021
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Additional evidence supports association of common genetic variants in MMP3 and TIMP2 with increased risk of chronic Achilles tendinopathy susceptibility

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Cited by 19 publications
(18 citation statements)
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“…A synergistic effect contributed to by all the cytokines from DPSC found in our data is possible; in particular, TIMP2 exists at a high level in DPSC-CM and is critical to the maintenance of tissue homeostasis. TIMP2 is an inhibitor for matrix metalloproteinase (MMP)-3 and 9, which have been shown to be highly related to a higher risk of soft tissue trauma, such as Achilles tendinopathy [38]. As for functional study of TIMP2 in the neural system, it was remarkably addressed to be beneficial for noise-related cochlear injury [39].…”
Section: Discussionmentioning
confidence: 99%
“…A synergistic effect contributed to by all the cytokines from DPSC found in our data is possible; in particular, TIMP2 exists at a high level in DPSC-CM and is critical to the maintenance of tissue homeostasis. TIMP2 is an inhibitor for matrix metalloproteinase (MMP)-3 and 9, which have been shown to be highly related to a higher risk of soft tissue trauma, such as Achilles tendinopathy [38]. As for functional study of TIMP2 in the neural system, it was remarkably addressed to be beneficial for noise-related cochlear injury [39].…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, the significant signals in TIMP2 gene were also identified in Han Chinese population from the 2019 study of Nie et al . 17 .…”
Section: Discussionmentioning
confidence: 99%
“…These samples come from a shared sample database that needs to be authorized, and the sample size of this database is constantly expanding. Since the subjects involved in the study of Nie et al 17 . were also from this sample database, the inclusion and exclusion criteria in details for our study subjects can refer to the study of Nie et al .…”
Section: Methodsmentioning
confidence: 99%
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“…MMP3 genes, including MMP3, are located on chromosome 11, 11q22.3. Several studies have found association between the variants within the MMP3 gene and tendon injuries [14][15][16][17], as well as with rotator cuff injury [18], arthritis [19] and ACL injuries [20]. To estimate a correlation between genotypes and injuries, it is important to include as many different populations as possible, due to the exhibition of different heterogeneities in different ethnic populations.…”
Section: Introductionmentioning
confidence: 99%