Additive Effect of ANRIL and BRAP Polymorphisms on Ankle-Brachial Index in a Taiwanese Population

Tsai, Pei‐Chien; Liao, Yi‐Chu; Lin, Tsung-Hsien; Hsi, Edward; Yang, Yi‐Hsin; Juo, Suh‐Hang Hank

doi:10.1253/circj.cj-11-0925

Cited by 27 publications

(17 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Targeted deletion of the orthologous ANRIL risk interval in mice can reduce expression of CDKN2A and CDKN2B in the heart and lead to excessive proliferation of vascular cells [36]. Indeed, subsequent studies showed that ANRIL expression is associated with the risk for coronary atherosclerosis, carotid arteriosclerosis, peripheral artery disease, and other vascular diseases [14, 16, 37, 38]. Carriers of the risk alleles showed increased whole blood RNA levels of ANRIL short variants DQ485454 and EU741058.1 , whereas the long variant DQ485453 was decreased [9].…”

Section: Discussionmentioning

confidence: 99%

Variants in ANRIL gene correlated with its expression contribute to myocardial infarction risk

et al. 2017

View full text Add to dashboard Cite

ANRIL (antisense non-coding RNA in the INK4 locus), located at the 9p21.3 locus, has been known to be closely associated with the risk of coronary artery disease (CAD). To date, studies of the 9p21.3 variants on CAD risk mainly focus on the non-coding region of ANRIL. However, the biological significance of the variants on ANRIL promoter and exons is still unknown. Here we investigate whether the variants on ANRIL promoter and exons have an effect on myocardial infarction (MI) risk, and further analyze the association of these variants with the expression of ANRIL transcript. We did not find any common variants with minor allele frequencies (MAF) larger than 5% in ANRIL promoter by sequencing 1.6kb upstream of the start codon. Unconditional logistic regression analysis revealed that two SNPs in ANRIL exons, rs10965215 and rs10738605, were significantly associated with MI risk. Further studies revealed that ANRIL transcript EU741058.1 expression levels of rs10965215 and rs10738605 risk genotypes were borderline lower than those of protective genotypes. Our data provide the evidence that the variants rs10965215 and rs10738605 in ANRIL exons contribute to MI risk in the Chinese Han population which might be correlated with the expression of its transcript EU741058.1.

show abstract

Section: Discussionmentioning

confidence: 99%

Variants in ANRIL gene correlated with its expression contribute to myocardial infarction risk

et al. 2017

View full text Add to dashboard Cite

show abstract

“…[53][54][55] This locus is adjacent to the last exon of a lncRNA named antisense noncoding RNA in the INK4 locus (ANRIL, also known as CDKN2BAS), whereas the 2 other protein-coding genes (cyclin-dependent kinase inhibitors 2A and 2B;CDKN2A and CDKN2B, respectively) lie >100 kb from associated single nucleotide polymorphisms (SNPs), suggesting that SNPs on ANRIL are more likely to contribute to the susceptibility of CAD. Indeed, subsequent studies showed that ANRIL expression is associated with the risk for coronary atherosclerosis, 56 carotid arteriosclerosis, 57 peripheral artery disease, 58 and other vascular disease (for review, see reference 59).…”

Section: Insights From Genetic Studiesmentioning

confidence: 99%

Long Noncoding RNAs in Cardiovascular Diseases

Uchida

Dimmeler

2015

Circulation Research

679

464

View full text Add to dashboard Cite

show abstract

“…The C allele of rs1333049 (as the optimal proxy of rs10757278; D 0 ¼ 1) 24,29 has been shown to be associated with lower ABI and increased risk of PAD than the G allele. 21 Others found a similar association between ABI and rs10757278 and rs1333049, 22,23 but further studies indicated no association between rs10757278 and PAD. 11,24 The variant forms of rs10757278 and rs10757274 were found to increase the risk of PAD in the present study of a Han Chinese population.…”

Section: Discussionmentioning

confidence: 96%

9p21 Polymorphisms increase the risk of peripheral artery disease in the Han Chinese population

et al. 2013

View full text Add to dashboard Cite

Objective: A case-control study to investigate the association of the 9p21 single nucleotide polymorphisms (SNPs) rs10757274 and rs10757278 (known to be associated with coronary artery disease [CAD] risk) with peripheral arterial disease (PAD), in a Han Chinese population. Methods: The rs10757274 and rs10757278 genotypes of patients with PAD, and age-and sex-matched control subjects, were determined. Multivariate unconditional logistic regression analyses were performed, with adjustments for age, sex, hypertension, dyslipidaemia, diabetes and smoking status. Results: The study included 420 patients with PAD and 418 control subjects. Variant forms of both SNPs were associated with increased risk of PAD in the total study population, when excluding patients with CAD or stroke (additive genetic model). The GG haplotype increased the risk of PAD, but this association did not remain significant after further sensitivity analysis. Both SNPs were associated with PAD risk in patients aged <65 years, but not in those aged !65 years (additive model). Conclusions: 9p21 is associated with PAD. When stratified according to age, 9p21 increases PAD risk in individuals aged <65 years, but not in those aged !65 years.

show abstract

Additive Effect of ANRIL and BRAP Polymorphisms on Ankle-Brachial Index in a Taiwanese Population

Cited by 27 publications

References 38 publications

Variants in ANRIL gene correlated with its expression contribute to myocardial infarction risk

Variants in ANRIL gene correlated with its expression contribute to myocardial infarction risk

Long Noncoding RNAs in Cardiovascular Diseases

9p21 Polymorphisms increase the risk of peripheral artery disease in the Han Chinese population

Contact Info

Product

Resources

About