Additive Free Fe-Catalyzed Conversion of Nitro to Aldehyde under Continuous Flow Module

Abstract

Fe-catalyzed direct transformation of nitro compounds to aldehyde under batch/continuous flow module is reported. This catalytic transformation is highly selective for syntheses of various aldehydes and does not require any additional additives such as bases and oxidants. Furthermore, the heterogeneous Fe–zeolite catalyst is recoverable and reusable for more than five cycles and offers gram-scale synthesis without the loss of catalytic efficiency. This heterogeneous catalyst has a maximum TOF of 5.93 h–1.

Continuous-flow Fe-zeolite-catalyzed temperature-directed synthesis of bioactive tetraketones and xanthenes using epoxides and cyclic-1,3-diketones via a Meinwald rearrangement

“…Previously, our group reported the iron zeolite-catalyzed transformation of an aromatic nitro group to carbonyl under continuous flow. 31 We also reported the magnetic iron oxide nanoparticles-catalyzed C–H peroxidation 32 and MnO 2 @Fe 3 O 4 magnetic nanoparticles-catalyzed oxidation of benzylic sp 3 C–H groups under a continuous flow process. 33…”

“…5 Previously, our group reported the iron zeolite-catalyzed transformation of an aromatic nitro group to carbonyl under continuous flow. 31 We also reported the magnetic iron oxide nanoparticles-catalyzed C-H peroxidation 32 and MnO 2 @Fe 3 -O 4 magnetic nanoparticles-catalyzed oxidation of benzylic sp 3 C-H groups under a continuous flow process. 33 Herein, we report the direct synthesis of tetraketone from epoxide and cyclic-1,3-diketone using an environmentally benign Fe-zeolite catalyst for the first time.…”