Additive solutions differentially affect metabolic and functional parameters of platelet concentrates

Leitner, Gerda; List, Jana; Horvath, Michaela; Eichelberger, Beate; Panzer, Simon; Jilma‐Stohlawetz, Petra

doi:10.1111/vox.12317

Cited by 27 publications

(46 citation statements)

References 26 publications

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“…The concentration of sCD40L and sCD62P varied significantly over time in PCs; however, their increases were more substantial in PPCs than SDA‐PCs. Moreover, the level of sCD40L was greater in SDA‐PCs stored in PAS‐D than those in SDA‐PCs stored in PAS‐E, consistent with previous reports . Storage of platelets in PAS has a number of benefits, including a reduction of serious adverse reactions .…”

Section: Discussionsupporting

confidence: 90%

Soluble CD40L and CD62P levels differ in single‐donor apheresis platelet concentrates and buffy coat–derived pooled platelet concentrates

et al. 2018

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BACKGROUND Platelet storage lesions are structural and biochemical changes in platelet concentrates (PCs), and depend on variables in collection and processing, as well as secondary procedures and storage conditions; such lesions can be mitigated by the use of platelet additive solutions (PASs). STUDY DESIGN AND METHODS This study investigated release of the inflammatory markers sCD40L and sCD62P by single‐donor apheresis platelet concentrates (SDA‐PCs) and buffy coat–derived pooled platelet concentrates (PPCs) before and after storage. SDA‐PC and PPC samples (n = 9089) processed by various methods and stored for different durations were obtained following production in one regional setting, the French National Blood Service. Soluble factors were quantified in PC supernatants immediately after processing and at the time of delivery, using biological testing technology (Luminex). RESULTS SDA‐PCs appeared more activated than PPCs at the end of the production step (i.e., prior to storage); however, proinflammatory soluble factors exhibited greater increases in PPCs than in SDA‐PCs during storage. In SDA‐PCs, PAS‐D (65%) led to reduced secretion of sCD62P, but favored secretion of sCD40L, compared with the alternative PAS‐E. CONCLUSION These data stress the importance of the production (processing) steps of PC manufacture and of storage. The extent to which they affect patient outcomes awaits further investigation in clinical studies.

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Section: Discussionsupporting

confidence: 90%

Soluble CD40L and CD62P levels differ in single‐donor apheresis platelet concentrates and buffy coat–derived pooled platelet concentrates

et al. 2018

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“…Disappearance of glucose in Amicus PCs suggests that the energy needs exceeded their capacity for oxidative metabolism . With the depletion of glucose on Day 7 on the Amicus platform, a decline in glycolysis may occur . Previous studies confirm the importance of glucose consumption and lactate production as they correlate to in vivo PLT survival and recovery .…”

Section: Discussionmentioning

confidence: 90%

“…An Amicus platform study showed the presence of glucose until the end of storage . Disappearance of glucose in Amicus PCs suggests that the energy needs exceeded their capacity for oxidative metabolism . With the depletion of glucose on Day 7 on the Amicus platform, a decline in glycolysis may occur .…”

Section: Discussionmentioning

confidence: 99%

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Influence of platelet preparation techniques on in vitro storage quality after psoralen‐based photochemical treatment using new processing sets for triple‐dose units

Lotens¹,

Valensart²,

Najdovski³

et al. 2018

Transfusion

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BACKGROUND: The INTERCEPT Blood System (IBS)for platelets (PLTs) uses a combination of psoralen and ultraviolet-A light to inactivate pathogens that may contaminate PLT concentrates (PCs). However, no data are available on the quality of IBS-treated PLTs from different apheresis and buffy-coat PC preparation platforms using the new triple storage (TS) set. STUDY DESIGN AND METHODS:The objective of this study was to evaluate the TS set on three different preparation platforms compared with the large-volume (LV) set, as control. PLT in vitro metabolic and activation parameters were studied over 7 days.RESULTS: Several statistical differences are observed between the two sets, particularly for pH, oxygen pressure (pO 2 ), carbonic gaz pressure (pCO 2 ), and bicarbonate. The three different preparation techniques influence PLT parameters, and the difference is statistically significant for all the studied parameters, except for pCO 2 . The TS set has the advantage of shorter compound adsorption device time, higher PLT recoveries, and less PLT activation. ABBREVIATIONS: APC = apheresis platelet concentrate; ATP = adenosine triphosphate; BC = buffy-coat; BCPC = buffy-coat platelet concentrate; CAD = compound adsorption device; ELISA = enzymelinked immunosorbent assay; HCO 3 = bicarbonate; IBS = INTERCEPT Blood System; LDH = lactate dehydrogenase; LV = large volume; PAS = platelet additive solution; PC(s) = platelet concentrate(s); PI = pathogen inactivation; PLT = platelet; TACSI PL = Terumo automated centrifuge and separator integration platelet; TS = triple storage; UV = ultraviolet.From the

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“…Various platelet additive solutions have been compared in several studies and found to have an effect on the product quality . Platelets stored in newer generation PASs have an improved quality compared to the ones stored in PAS B.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of soluble glycoprotein V as an in vitro quality marker for platelet concentrates: a correlation study between in vitro platelet quality markers and the effect of storage medium

2016

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We propose that quantitative sGPV which is calculated per platelet number could be used as the first choice in vitro platelet activation marker in validations and monitoring platelet production processes. sGPV could also be a promising alternative to platelet activation assays used in interlaboratory comparisons of the quality of platelet concentrates. Quantitative lactate and lactate production rate can be used to evaluate the quality of platelets concentrates during storage. However, the formation of lactate depends on the platelet count and the amount of glucose in the product making the comparison more difficult.

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Additive solutions differentially affect metabolic and functional parameters of platelet concentrates

Cited by 27 publications

References 26 publications

Soluble CD40L and CD62P levels differ in single‐donor apheresis platelet concentrates and buffy coat–derived pooled platelet concentrates

Soluble CD40L and CD62P levels differ in single‐donor apheresis platelet concentrates and buffy coat–derived pooled platelet concentrates

Influence of platelet preparation techniques on in vitro storage quality after psoralen‐based photochemical treatment using new processing sets for triple‐dose units

Evaluation of soluble glycoprotein V as an in vitro quality marker for platelet concentrates: a correlation study between in vitro platelet quality markers and the effect of storage medium

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