Addressing the conundrum of male predominance in mantle cell lymphoma using androgen receptor blockade

Abstract

BU/fludarabine plus melphalan or TBI in unrelated cord blood transplantation for high-risk hematological diseases.

Bisphenol A-induced DNA damages promote to lymphoma progression in human lymphoblastoid cells through aberrant CTNNB1 signaling pathway

“…BPA regulates the function of AR via multiple ways ( Lee et al., 2003 ; Pelch et al., 2019 ; Teng et al., 2013 ). AR blockade has been investigated for MCL therapy ( Chow et al., 2020 ; Mostaghel et al., 2017 ), a high-grade lymphoma with male predominance ( Aghajanpour-Mir et al., 2016 ), and increased AR expression ( Mostaghel et al., 2017 ). Androgens were demonstrated to promote mRNA expression of IGF1 (insulin-like growth factor 1) and its receptor in the primate ovary ( Aghajanpour-Mir et al., 2016 ).…”