Bisphenol A-induced DNA damages promote to lymphoma progression in human lymphoblastoid cells through aberrant CTNNB1 signaling pathway

Chen, Yin‐Kai; Tan, Yanyan; Yao, Min; Lin, Ho-Chen; Tsai, Mon-Hsun; Li, Yu-Yun; Hsu, Yih-Jen; Huang, Sheng‐Tung; Chang, Chia‐Wei; Cheng, Chih-Ming; Chuang, C.P.

doi:10.1016/j.isci.2021.102888

Cited by 12 publications

(10 citation statements)

References 87 publications

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“…There is increasing concern that BPA perturbs the immune system causing adverse health effects including cancer [ 179 , 180 , 181 ]. It has recently been shown that BPA-induced DNA damages promote lymphoma progression in human lymphoblastoid cells through the aberrant catenin-β1 signaling pathway [ 37 ]. Gene-network analysis of microarray data sets in human lymphoma tissues as well as in human cells with BPA exposure to explore module genes identified potential pathways for lymphomagenesis in response to BPA [ 37 ].…”

Section: Potential Milk-related Factors Promoting Dlbclmentioning

confidence: 99%

“…It has recently been shown that BPA-induced DNA damages promote lymphoma progression in human lymphoblastoid cells through the aberrant catenin-β1 signaling pathway [ 37 ]. Gene-network analysis of microarray data sets in human lymphoma tissues as well as in human cells with BPA exposure to explore module genes identified potential pathways for lymphomagenesis in response to BPA [ 37 ]. BPA exposure resulted in a disrupted cell cycle and DNA damage by activating catenin-β1 encoded on the catenin-β1 gene ( CTNNB1 ), the initiator of the aberrant constructed CTNNB1-NFKB1-AR-IGF-1-TWIST1 pathway, which may potentially lead to lymphomagenesis [ 37 ].…”

Section: Potential Milk-related Factors Promoting Dlbclmentioning

confidence: 99%

“…Gene-network analysis of microarray data sets in human lymphoma tissues as well as in human cells with BPA exposure to explore module genes identified potential pathways for lymphomagenesis in response to BPA [ 37 ]. BPA exposure resulted in a disrupted cell cycle and DNA damage by activating catenin-β1 encoded on the catenin-β1 gene ( CTNNB1 ), the initiator of the aberrant constructed CTNNB1-NFKB1-AR-IGF-1-TWIST1 pathway, which may potentially lead to lymphomagenesis [ 37 ]. Activated catenin-β1 suppresses the DNA-repair-associated genes TP53 and CDKN1A [ 37 ].…”

Section: Potential Milk-related Factors Promoting Dlbclmentioning

confidence: 99%

“…Prior radiation treatment, obesity, and smoking are most highly associated with DLBCL as well as infections with human immunodeficiency virus (HIV), Epstein–Barr virus (EBV), and human herpes virus 8 (HHV8) [ 30 ]. Drugs like phenytoin, digoxin, and TNF antagonists are also associated with lymphomagenesis as well as organic chemicals, pesticides, bisphenol A, phenoxy-herbicides, glyphosate, wood preservatives, dust, hair dyes, solvents, and prior chemotherapy [ 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ].…”

Section: Introductionmentioning

confidence: 99%

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Potential Pathogenic Impact of Cow’s Milk Consumption and Bovine Milk-Derived Exosomal MicroRNAs in Diffuse Large B-Cell Lymphoma

Melnik

Stadler

Weiskirchen

et al. 2023

IJMS

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Epidemiological evidence supports an association between cow’s milk consumption and the risk of diffuse large B-cell lymphoma (DLBCL), the most common non-Hodgkin lymphoma worldwide. This narrative review intends to elucidate the potential impact of milk-related agents, predominantly milk-derived exosomes (MDEs) and their microRNAs (miRs) in lymphomagenesis. Upregulation of PI3K-AKT-mTORC1 signaling is a common feature of DLBCL. Increased expression of B cell lymphoma 6 (BCL6) and suppression of B lymphocyte-induced maturation protein 1 (BLIMP1)/PR domain-containing protein 1 (PRDM1) are crucial pathological deviations in DLBCL. Translational evidence indicates that during the breastfeeding period, human MDE miRs support B cell proliferation via epigenetic upregulation of BCL6 (via miR-148a-3p-mediated suppression of DNA methyltransferase 1 (DNMT1) and miR-155-5p/miR-29b-5p-mediated suppression of activation-induced cytidine deaminase (AICDA) and suppression of BLIMP1 (via MDE let-7-5p/miR-125b-5p-targeting of PRDM1). After weaning with the physiological termination of MDE miR signaling, the infant’s BCL6 expression and B cell proliferation declines, whereas BLIMP1-mediated B cell maturation for adequate own antibody production rises. Because human and bovine MDE miRs share identical nucleotide sequences, the consumption of pasteurized cow’s milk in adults with the continued transfer of bioactive bovine MDE miRs may de-differentiate B cells back to the neonatal “proliferation-dominated” B cell phenotype maintaining an increased BLC6/BLIMP1 ratio. Persistent milk-induced epigenetic dysregulation of BCL6 and BLIMP1 expression may thus represent a novel driving mechanism in B cell lymphomagenesis. Bovine MDEs and their miR cargo have to be considered potential pathogens that should be removed from the human food chain.

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Section: Potential Milk-related Factors Promoting Dlbclmentioning

confidence: 99%

Section: Potential Milk-related Factors Promoting Dlbclmentioning

confidence: 99%

Section: Potential Milk-related Factors Promoting Dlbclmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Potential Pathogenic Impact of Cow’s Milk Consumption and Bovine Milk-Derived Exosomal MicroRNAs in Diffuse Large B-Cell Lymphoma

Melnik

Stadler

Weiskirchen

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…BPA exposure has been described to result in disrupted cell cycle and DNA damage by activating Catenin Beta 1 (CTNNB1), which is the initiator of the aberrant constructed CTNNB1-nuclear factor kappa-B1 (NFKB1)-AR-insulin-like growth factor-1 (IGF1)-Twist-related protein 1 (TWIST1) pathway, potentially leading to lymphomagenesis [ 76 ].…”

Section: Bisphenol a Effects On Human Healthmentioning

confidence: 99%

Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions

et al. 2023

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Bisphenol A (BPA) is one of the so-called endocrine disrupting chemicals (EDCs) and is thought to be involved in the pathogenesis of different morbid conditions: immune-mediated disorders, type-2 diabetes mellitus, cardiovascular diseases, and cancer. The purpose of this review is to analyze the mechanism of action of bisphenol A, with a special focus on mesenchymal stromal/stem cells (MSCs) and adipogenesis. Its uses will be assessed in various fields: dental, orthopedic, and industrial. The different pathological or physiological conditions altered by BPA and the related molecular pathways will be taken into consideration.

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Impact of plastic-related compounds on the gene expression signature of HepG2 cells transfected with CYP3A4

Rosellini,

Omer,

Schulze

et al. 2023

Arch Toxicol

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The presence of plastic and microplastic within the oceans as well as in marine flora and fauna have caused a multitude of problems that have been the topic of numerous investigations for many years. However, their impact on human health remains largely unknown. Such plastic and microplastic particles have been detected in blood and placenta, underlining their ability to enter the human body. Plastics also contain other compounds, such as plasticizers, antioxidants, or dyes, whose impact on human health is currently being studied. Critical enzymes within the metabolism of endogenous molecules, especially of xenobiotics, are the cytochrome P450 monooxygenases (CYPs). Although their importance in maintaining cellular balance has been confirmed, their interactions with plastics and related products are poorly understood. In this study, the possible relationship between different plastic-related compounds and CYP3A4 as one of the most important CYPs was analyzed using hepatic cells overexpressing this enzyme. Beginning with virtual compound screening and molecular docking of more than 1000 plastic-related compounds, several candidates were identified to interact with CYP3A4. In a second step, RNA-sequencing was used to study in detail the transcriptome-wide gene expression levels affected by the selected compounds. Three candidate molecules ((2,2′-methylenebis(6-tert-butyl-4-methylphenol), 1,1-bis(3,5-di-tert-butyl-2-hydroxyphenyl)ethane, and 2,2′-methylenebis(6-cyclohexyl-4-methylphenol)) had an excellent binding affinity to CYP3A4 in-silico as well as cytotoxic effects and interactions with several metabolic pathways in-vitro. We identified common pathways influenced by all three selected plastic-related compounds. In particular, the suppression of pathways related to mitosis and ‘DNA-templated DNA replication’ which were confirmed by cell cycle analysis and single-cell gel electrophoresis. Furthermore, several mis-regulated metabolic and inflammation-related pathways were identified, suggesting the induction of hepatotoxicity at different levels. These findings imply that these compounds may cause liver problems subsequently affecting the entire organism.

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Bisphenol A-induced DNA damages promote to lymphoma progression in human lymphoblastoid cells through aberrant CTNNB1 signaling pathway

Cited by 12 publications

References 87 publications

Potential Pathogenic Impact of Cow’s Milk Consumption and Bovine Milk-Derived Exosomal MicroRNAs in Diffuse Large B-Cell Lymphoma

Potential Pathogenic Impact of Cow’s Milk Consumption and Bovine Milk-Derived Exosomal MicroRNAs in Diffuse Large B-Cell Lymphoma

Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions

Impact of plastic-related compounds on the gene expression signature of HepG2 cells transfected with CYP3A4

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