Adduction of Hemoglobin and Albumin in Vivo by Metabolites of Trichloroethylene, Trichloroacetate, and Dichloroacetate in Rats and Mice

Monovalent Fc receptor blockade by an anti–Fcγ receptor/albumin fusion protein ameliorates murine ITP with abrogated toxicity

“…Previous findings show that the half-life of albumin in humans is ;13 to 18 days, 27,28 whereas that of mice is ;1 day. 29 The findings in this in vivo pharmacokinetics study are therefore consistent with previous reports and support the establishment that the half-life of albumin in mice is shorter than humans.…”

Albumin Binding as a General Strategy for Improving the Pharmacokinetics of Proteins

“…3 In mice, the 10.4 h half-life for D3H44-L represents a 26-fold improvement. Interestingly, these halflives correlate with the reported half-life of albumin in these species of 5-6 days in rabbits (29) and 1 day in mice (30). Despite potential metabolism differences and the weaker affinity for human albumin (Table III), the 19-day half-life for human albumin suggests that large improvements in the halflife of a Fab in human are possible.…”

Chronic exposure to trichloroethene causes early onset of SLE-like disease in female MRL +/+ mice

“…A trifluoroanalogue of DCAC (trifluoroacylchloride) has been shown to acylate proteins, producing antigens involved in halothane-induced hepatitis Phol et al, 1991;Kenna et al, 1993;Chrsiten et al, 1994) and also, 2,2-dichlorotrifluoroethane-related liver disease (Hoet et al, 1997;White et al 2001). Similarly, covalent binding of TCE in vivo has been observed in rodents Bolt and Filser, 1977;Stot et al, 1982;Mazzullo et al, 1992;Stevens et al, 1992;Kautiainen et al, 1997). TCE-oxide and DCAC can covalently modify proteins directly to form protein adducts (Bloemen et al, 2001;Halmes et al, 1996Halmes et al, , 1997.…”