Adenocarcinoma Arising from Gastric Heterotopia in the Jejunal Mucosa of a Beagle Dog

Panigrahi, D; Johnson, Alexander; Wosu, N. J.

doi:10.1177/030098589403100225

Cited by 5 publications

(8 citation statements)

References 8 publications

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“…Described HGM in dogs often consists of several epithelial cell types, corresponding to normal gastric mucosa [ 16 , 17 , 33 ]. These could also extend into the submucosa [ 16 ], which has been also reported in humans [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

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Life-threatening gastrointestinal bleeding caused by jejunal heterotopic gastric mucosa in an adult dog: a rare case report

Merca

Richter

2022

BMC Vet Res

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Background Heterotopic gastric mucosa has been scarcely reported in the veterinary literature. Its presence can be asymptomatic or associated with various clinical signs ranging from apathy, vomiting, to abdominal pain. This report illustrates the presence of heterotopic gastric mucosa in the jejunum of an adult dog. It is the first to describe severe anemia, requiring acute blood transfusion, following intestinal hemorrhage caused by heterotopic gastric mucosa. Case presentation A twelve-year-old, intact male Maltese dog was presented with a history of apathy, vomiting and anemia. The dog was on a strict diet for recurrent diarrhea, food intolerance and skin allergy. Clinical examination revealed severe anemic mucous membranes and painful abdominal palpation. Blood examination confirmed severe regenerative anemia. Ultrasonography showed an intestinal neoplasm, gall bladder sludge and non-homogeneous liver parenchyma. Three-view thoracic radiographs failed to show any metastatic lesions or enlarged lymph nodes. After initial stabilization and blood transfusion, a midline exploratory laparotomy was performed. Three different masses were found in the jejunum. Resection and anastomosis of approximately 40 cm of jejunum was performed, followed by liver and lymph node biopsy and placement of an esophagostomy tube. Two days after surgery the dog started to clinically improve and was discharged from the hospital on the sixth day after surgery. Histopathology revealed the intestinal masses to be heterotopic gastric mucosa associated with intramural cystic distensions, multifocal ulceration and bleeding into the intestinal lumen. Two years after surgery, the dog did not have a recurrence of anemia or gastrointestinal signs. Conclusions This case demonstrates that heterotopic gastric mucosa can be considered one of the differential diagnoses in case of severe anemia due to gastrointestinal hemorrhage and suspected intestinal tumors. Although in most described cases in literature the finding seems to be incidental on necropsy, our report shows that heterotopic gastric mucosa can be the etiology of life-threatening signs. In addition, because no recurrent diarrhea episodes occurred after surgical resection of the ectopic tissue, it is likely that the heterotopic gastric mucosa was the cause of the food intolerance signs in this dog.

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Section: Discussionmentioning

confidence: 99%

“…It has been reported in children[ 15 ] and in adults [ 9 ] with most patients being alive at the time of diagnosis. Conversely, the veterinary literature describes mostly HGM as an incidental finding during necropsy in dogs [ 16 , 17 ] and cats [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Life-threatening gastrointestinal bleeding caused by jejunal heterotopic gastric mucosa in an adult dog: a rare case report

Merca

Richter

2022

BMC Vet Res

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“…Panigrahi later described a single case of acinar adenocarcinoma arising from heterotopic gastric mucosa in the jejunum of a Beagle dog. 3 A case report of a person with this condition included a review of the literature and included the most common clinical characteristics of jejunal heterotopic gastric mucosa in children: polypoid lesions resulting in intermittent intussusception and abdominal pain. 12 An alternate form of a heterotopic tissue lesion described in a dog associated with acute onset vomiting and abdominal pain was noted by Cooper.…”

Section: Discussionmentioning

confidence: 99%

“…There was an increased incidence in male (12/187) versus female (3/178) dogs. Panigrahi later described a single case of acinar adenocarcinoma arising from heterotopic gastric mucosa in the jejunum of a Beagle dog . A case report of a person with this condition included a review of the literature and included the most common clinical characteristics of jejunal heterotopic gastric mucosa in children: polypoid lesions resulting in intermittent intussusception and abdominal pain .…”

Section: Discussionmentioning

confidence: 99%

“…1 Although it is not believed to frequently be associated with pathology, it has previously been found associated with cases of intestinal neoplasia, obstruction, and septic peritonitis secondary to diverticular rupture. 2,3 This report documents a case of surgically managed acute abdomen in a young dog secondary to abscess formation within a closed diverticulum of heterotopic gastric mucosa.…”

Section: Abbreviationsmentioning

confidence: 96%

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