Adenocarcinoma of the cervix. A clinicopathologic study of 47 cases

Rombaut, R; Charles, David; Murphy, Arthur I.

doi:10.1002/1097-0142(196607)19:7<891::aid-cncr2820190702>3.0.co;2-y

Cited by 29 publications

(2 citation statements)

References 21 publications

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“…For cervical adenocarcinoma, there is no solid evidence regarding the most effective treatment approach (28). Many studies report that the use of RT within the pelvis is more effective for suppressing squamous cell carcinoma than adenocarcinoma (29)(30)(31)(32). A recent study reported no appreciable difference in the 5-year survival rate when RT, including CCRT, was compared with CT alone in the postoperative treatment of stages Ib-IIb cervical adenocarcinoma (33).…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Vascular Endothelial Growth Factor Expression and Microvessel Density in Invasive Cervical Cancer

et al. 2015

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To determine whether vascular endothelial growth factor (VEGF) expression and microvessel density are predictive of prognosis in cases of invasive cervical cancer, correlations among VEGF expression, microvessel density, and clinicopathological parameters were identified. VEGF expression was evaluated in 50 cervical cancer samples by immunohistochemical staining. Microvessel density was assessed by immunostaining for CD31-positive endothelial cells in the most vascularized areas of tumors. VEGF expression and microvessel density were significantly higher in adenocarcinomas than in squamous cell carcinomas. However, in cases of adenocarcinoma, no significant correlations were found among VEGF expression, microvessel density, and clinicopathological parameters. In contrast, for squamous cell carcinomas, microvessel density was significantly higher in cases at an advanced stage and in those with several other poor prognostic factors. The finding that cervical adenocarcinomas exhibited greater VEGF expression and microvessel density than squamous cell carcinomas may explain the poorer prognosis of adenocarcinoma compared with squamous cell carcinoma. Moreover, microvessel density in squamous cell carcinomas was significantly correlated with poor prognostic factors. Therefore, there is possibility that bevacizumab, a humanized monoclonal antibody against VEGF-A, may be useful in the initial treatment targeting angiogenesis for early-stage cervical cancer.

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Section: Discussionmentioning

confidence: 99%

Clinical Significance of Vascular Endothelial Growth Factor Expression and Microvessel Density in Invasive Cervical Cancer

et al. 2015

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“…The present Korean series has been analysed without respect to pre-or post-menopausal state; we had incomplete information on this and other clinical factors in a number of patients, and the subdivision of the cases has been based on conventional histological criteria only. Nielson et al (24) give the peak age incidence in cases of intra-epithelial carcinoma in the [30][31][32][33][34][35][36][37][38][39] bracket, and the mode of the age distribution was at 40 years in 140 Swedish cases 1921-53 (13). The age range is wide, however, and according to Hertig & Gore (10) from the twenties to the seventies.…”

Section: Discussionmentioning

confidence: 99%

Cancer of the Uterine Cervix in a Korean Biopsy Series: With a Study of the Age Distribution in 1889 Cases of Chronic Cervicitis, Dysplasia, Intra‐epithelial and Invasive Epidermoid Carcinoma

Wetteland¹

1971

Acta Obstet Gynecol Scand

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Invasive cervical carcinoma is the most commonly observed primary form of cancer in Korean females. This tumour constituted 37.6% of 1820 malignant tumours of known primary site encountered in a Korean surgical series at the Scandinavian‐sponsored National Medical Center in Seoul from December 1958 to August 1967. The age at diagnosis of invasive cervical cancer averaged 43.6 years, and the estimated population peak incidence was also within the fifth decade. Ninety‐five per cent of the cases were of the epidermoid type; the range of age among patients with adenocarcinoma was significantly greater than in those with epidermoid cancer. The age distribution of 1889 cases of simple chronic cervicitis, squamous‐cell dysplasia, intra‐epithelial neoplasia and invasive epidermoid carcinoma is presented and discussed. The observations in 1033 cases of progressive epithelial abnormalities are consistent with a linear regression of age at diagnosis on histological grade of epithelial alterations ranging from slight dysplasia to late invasive epidermoid cancer. Such an interrelation constitutes one among several circumstantial pieces of evidence that the morphological evolution of invasive epidermoid carcinoma passes through a spectrum of epithelial abnormalities. The present results support this concept of a step‐wise progression in epidermoid cervical carcinogenesis.

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Mesonephric adenocarcinomas of the cervix

Hart

Norris

1972

Cancer

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Adenocarcinoma of mesonephric type is a rare primary tumor of the cervix. Thirteen examples, representing 3% of primary cervical adenocarcinomas in our files, were studied. The neoplasms were commonly polypoid and exophytic and, in 10 instances, were clinically confined to the cervix (Stage I) at time of initial pelvic examination. Microscopically, they were composed of clear and hobnail‐type cells arranged in mixtures of papillary, tubular, and solid patterns. Clusters of small tubules resembling mesonephric remnants were identified at the base of the tumor or in the adjacent stroma in 5 cases. These tubules showed varying degrees of atypicality and merged with infiltrating adenocarcinoma in 3 instances, indicating that some cervical adenocarcinomas of this histologic type do arise from mesonephric remnants. Although an associated in‐situ carcinoma was not found, origin from cervical epithelium is also likely for some examples. No single explanation for the histogenesis is sufficient, inasmuch as identical neoplasms arise from different tissues in the endometrium, ovary, and vagina. The actuarial survival was 55% at 5 years and 40% at 10 years. The number of cases compiled so far is inadequate to determine the best mode of therapy for this lesion.

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Adenocarcinoma of the cervix. A clinicopathologic study of 47 cases

Cited by 29 publications

References 21 publications

Clinical Significance of Vascular Endothelial Growth Factor Expression and Microvessel Density in Invasive Cervical Cancer

Clinical Significance of Vascular Endothelial Growth Factor Expression and Microvessel Density in Invasive Cervical Cancer

Cancer of the Uterine Cervix in a Korean Biopsy Series: With a Study of the Age Distribution in 1889 Cases of Chronic Cervicitis, Dysplasia, Intra‐epithelial and Invasive Epidermoid Carcinoma

Mesonephric adenocarcinomas of the cervix

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