Clinical Significance of Vascular Endothelial Growth Factor Expression and Microvessel Density in Invasive Cervical Cancer

Saijo, Yasuyo; Furumoto, Hiroyuki; Yoshida, Kanako; Nishimura, Masato; Irahara, Minoru

doi:10.2152/jmi.62.154

Cited by 14 publications

(11 citation statements)

References 29 publications

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“…Adenocarcinomas of the cervix exhibit a higher expression of vascular endothelial growth factor and thus a higher density of microvasculature in the tumor stroma (18) when compared to squamous cell cancer or the normal cervix uteri (19). This is in agreement with the higher F p found in the adenocarcinomas in this study.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Cervical Cancer with a Parameter-Free Intravoxel Incoherent Motion Imaging Algorithm

et al. 2017

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ObjectiveTo evaluate the feasibility of a parameter-free intravoxel incoherent motion (IVIM) approach in cervical cancer, to assess the optimal b-value threshold, and to preliminarily examine differences in the derived perfusion and diffusion parameters for different histological cancer types.Materials and MethodsAfter Institutional Review Board approval, 19 female patients (mean age, 54 years; age range, 37–78 years) gave consent and were enrolled in this prospective magnetic resonance imaging study. Clinical staging and biopsy results were obtained. Echo-planar diffusion weighted sequences at 13 b-values were acquired at 3 tesla field strength. Single-sliced region-of-interest IVIM analysis with adaptive b-value thresholds was applied to each tumor, yielding the optimal fit and the optimal parameters for pseudodiffusion (D*), perfusion fraction (Fp) and diffusion coefficient (D). Monoexponential apparent diffusion coefficient (ADC) was calculated for comparison with D.ResultsBiopsy revealed squamous cell carcinoma in 10 patients and adenocarcinoma in 9. The b-value threshold (median [interquartile range]) depended on the histological type and was 35 (22.5–50) s/mm2 in squamous cell carcinoma and 150 (100–150) s/mm2 in adenocarcinoma (p < 0.05). Comparing squamous cell vs. adenocarcinoma, D* (45.1 [25.1–60.4] × 10−3 mm2/s vs. 12.4 [10.5–21.2] × 10−3 mm2/s) and Fp (7.5% [7.0–9.0%] vs. 9.9% [9.0–11.4%]) differed significantly between the subtypes (p < 0.02), whereas D did not (0.89 [0.75–0.94] × 10−3 mm2/s vs. 0.90 [0.82–0.97] × 10−3 mm2/s, p = 0.27). The residuals did not differ (0.74 [0.60–0.92] vs. 0.94 [0.67–1.01], p = 0.32). The ADC systematically underestimated the magnitude of diffusion restriction compared to D (p < 0.001).ConclusionThe parameter-free IVIM approach is feasible in cervical cancer. The b-value threshold and perfusion-related parameters depend on the tumor histology type.

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Section: Discussionmentioning

confidence: 99%

Assessment of Cervical Cancer with a Parameter-Free Intravoxel Incoherent Motion Imaging Algorithm

et al. 2017

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“…These newly formed vessels nourish the growing tumor and provide additional routes for CC metastasis [ 20 , 21 ]. Accordingly, higher intra-tumor vessel density is associated with CC aggressiveness or recurrence and poorer patient survival [ 22 , 23 ].…”

Section: Role Of the Hpv-e5 E6 And E7 Proteins In The Developmentmentioning

confidence: 99%

“…Because of its role in the development and clinical progression of uterine cervical lesions [ 22 , 23 , 100 ], angiogenesis is a rational target for the treatment of high-grade CIN and/or CC. Accordingly, antagonists of angiogenic growth factors have been found active against recurrent CC [ 20 ].…”

Section: The Anti-angiogenesis Effect Of the Hiv-pi And Its Possibmentioning

confidence: 99%

The Impact of Human Papilloma Viruses, Matrix Metallo-Proteinases and HIV Protease Inhibitors on the Onset and Progression of Uterine Cervix Epithelial Tumors: A Review of Preclinical and Clinical Studies

Barillari

Monini

Sgadari

et al. 2018

IJMS

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Infection of uterine cervix epithelial cells by the Human Papilloma Viruses (HPV) is associated with the development of dysplastic/hyperplastic lesions, termed cervical intraepithelial neoplasia (CIN). CIN lesions may regress, persist or progress to invasive cervical carcinoma (CC), a leading cause of death worldwide. CIN is particularly frequent and aggressive in women infected by both HPV and the Human Immunodeficiency Virus (HIV), as compared to the general female population. In these individuals, however, therapeutic regimens employing HIV protease inhibitors (HIV-PI) have reduced CIN incidence and/or clinical progression, shedding light on the mechanism(s) of its development. This article reviews published work concerning: (i) the role of HPV proteins (including HPV-E5, E6 and E7) and of matrix-metalloproteinases (MMPs) in CIN evolution into invasive CC; and (ii) the effect of HIV-PI on events leading to CIN progression such as basement membrane and extracellular matrix invasion by HPV-positive CIN cells and the formation of new blood vessels. Results from the reviewed literature indicate that CIN clinical progression can be monitored by evaluating the expression of MMPs and HPV proteins and they suggest the use of HIV-PI or their derivatives for the block of CIN evolution into CC in both HIV-infected and uninfected women.

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“…Increased expression of the inducible HIF-1α subunit has been suggested to predict an increased risk of tumour progression and treatment resistance in several types of solid tumours including sarcoma 15–17. Angiogenesis, measured through microvessel density (MVD), represents another feature described to have prognostic impact in several tumour types 18 19…”

Section: Introductionmentioning

confidence: 99%

Hypoxia-inducible factor 1α predicts recurrence in high-grade soft tissue sarcoma of extremities and trunk wall

et al. 2017

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Clinical Significance of Vascular Endothelial Growth Factor Expression and Microvessel Density in Invasive Cervical Cancer

Cited by 14 publications

References 29 publications

Assessment of Cervical Cancer with a Parameter-Free Intravoxel Incoherent Motion Imaging Algorithm

Assessment of Cervical Cancer with a Parameter-Free Intravoxel Incoherent Motion Imaging Algorithm

The Impact of Human Papilloma Viruses, Matrix Metallo-Proteinases and HIV Protease Inhibitors on the Onset and Progression of Uterine Cervix Epithelial Tumors: A Review of Preclinical and Clinical Studies

Hypoxia-inducible factor 1α predicts recurrence in high-grade soft tissue sarcoma of extremities and trunk wall

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