Adenocarcinoma of the rectum metastatic to the oral cavity. Two cases and a review of the literature

Abstract

Two cases of metastatic adenocarcinoma occurring in the oral cavity are presented. One patient experienced lip paresthesias and pain as the presenting complaint. The other patient developed a growth at the site of a recent tooth extraction, and had bony erosion of the adjacent maxilla. The literature on metastatic lesions to the oral cavity including mandible is reviewed. This problem has been described almost exclusively in the oral and dental surgery literature. The clinical symptoms and signs described here should suggest the possibility of metastatic tumor to the oral cavity, and may be the initial manifestation of malignant disease.

Metastatic colon carcinoma to the jaw: A case report and review of the literature

“…Surgery performed on patients with noncolonic neoplams in the form of mandibulectomy resulted in temporary palliation, but other metastatic foci soon appeared. Rusthoven et al [9] used a combination of 5-FU and radiotherapy, which offered some palliation of symptoms. In his other patient, Mitomycin C and radiotherapy produced no response.…”

“…In all cases described, the patients did uniformly poorly [9]. Life expectancy has been reported as short as one month and as long as seven months [3,6,9] Clausen and Poulsen [5] reported that 70% of the patients in their literature review had died within one year.…”

“…She also had a right upper lobe lung nodule, which may have represented another metastastic focus. In other studies, the patients have had additional metastatic disease in the ovary, [6], lung [6,11], and liver and lungs [9,13]. One patient had metastases to his bones, cervical, abdominal and thoracic lymph nodes, as well as to his thyroid, adrenals, liver, pancreas, right pleura, and lungs [S].…”

“…Tumor cells can then enter the bone through the nutrient arteries and proliferate in the medullary bone. Cortical perforation then allows the tumor to invade the adjacent soft tissue [3,9]. In the case presented here, the mecha-(i.e., histiocytosis X).…”

Metastatic Adenocarcinoma of the Colon: Early Manifestation in Gingival Tissue

“…The most frequent sites of metastatic spread are liver, lung and bone [5][6][7]. We report an unusual case of colon carcinoma that metastasized to the oral cavity soft tissue which was an early clinical sign of this disease.…”