Metastatic Adenocarcinoma of the Colon: Early Manifestation in Gingival Tissue

Soares, Andresa Borges; Thomaz, Luiz Alexandre; Duarte, Mauricio Texeira; Moraes, Paulo De Camargo; Araújo, Vera Cavalcanti de

doi:10.1007/s12105-010-0222-2

Cited by 15 publications

(12 citation statements)

References 13 publications

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“…To better understand the association between oral cavity metastases and colon cancer, 12 cases of oral cavity metastases of colon cancer, including the present case, were reviewed [6,7,[10][11][12][13][14][15][16][17][18]; Table I]. It was observed that mandibular metastases from colon cancer regularly occurred the sixth and seventh decades of life.…”

Section: Discussionmentioning

confidence: 99%

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Colon cancer metastasis to the mandibular gingiva with partial occult squamous differentiation: A case report and literature review

Ren

Huang

Yang

et al. 2016

Molecular and Clinical Oncology

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Metastasis is the primary cause of death among patients with colon cancer. However, the number of available studies regarding oral cavity metastases from colon cancer is currently limited. We herein report an unusual case of a 60-year-old male patient who developed an oral cavity metastasis from colon cancer. A total of 12 clinical case studies reporting colon cancer metastases to the mandibular gingival region were also reviewed, with the aim to elucidate the clinical and pathological characteristics of this disease entity in order to improve clinical diagnosis and treatment. It was demonstrated that patients with oral cavity metastases from colon cancer were predominantly in the sixth or seventh decades of life. The mandible was the main site of metastatic tumors to the oral cavity, while the occurrence of gingival metastases was comparatively rare. Moreover, the diagnoses of an oral metastatic tumor and primary colon cancer were often synchronous and were frequently accompanied with metastases to other organs. Several key aspects were suggested that should be accounted for when diagnosing colon cancer patients, including focusing attention to oral symptoms when examining cancer patients, utilizing a multidisciplinary approach for differential diagnosis and utilizing postoperative pathological examination to accurately diagnose the type of tumor and optimize the efficacy of treatment.

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Section: Discussionmentioning

confidence: 99%

“…Although liver metastases from colon cancer has a relatively favorable prognosis (progression-free survival of ~23 months), metastases from colon cancer remain to be further investigated (4,5). Moreover, colon cancer metastases to rare sites, such as the oral cavity, carry a worse prognosis (6).…”

Section: Introductionmentioning

confidence: 99%

Colon cancer metastasis to the mandibular gingiva with partial occult squamous differentiation: A case report and literature review

Ren

Huang

Yang

et al. 2016

Molecular and Clinical Oncology

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“…One important aspect of the biology of cancer is the development of metastases and their diagnosis is always challenging for both clinician and the pathologist, due to its rarity and complexity (Servato et al, 2013;Soares et al, 2011). Kwon et al (2006), proposed some criteria for metastatic tumor diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Primary Adenocarcinoma of the Colon with Metastases to the Mandible and Liver: A Case Report

Andrade

Gordón-Núñez

Galvão

et al. 2015

Int. J. Odontostomat.

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Metastatic lesions to the mandible may be originated from primary tumors elsewhere in the body. However, metastatic colonic carcinomas to this bone have been described infrequently. We report the case of a 71-year-old man with an adenocarcinoma in the sigmoid colon with liver metastasis. The patient underwent chemotherapy with indication of sigmoidectomy and retroperitoneal lymphadenectomy. One year and four months after the first metastatic diagnosis, the patient presented a tumor mass in the body and branch of the right mandible. Histopathological and immunohistochemical analysis with monoclonal antibodies specific for CEA, CK20, CDX-2, and vilin were compatible with the diagnosis of moderately differentiated metastatic adenocarcinoma with colonic origin. However, due to the wide spread of the disease, the patient died four months later. Tumor markers have been applied in clinical practice to assist in the diagnosis and to help guide prognosis, staging and treatment of cancer. The management of metastatic lesions remains a controversial issue and the development of new and more specific markers of gastrointestinal differentiation that may promote early diagnosis, are of continuous interest.

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“…The metastatic rate in the posterior body of the mandible is higher than that in the symphyseal region [ 5 ]. The gingivae (55 %) followed by the tongue (30 %) are the most common soft tissue sites affected by metastatic malignancy [ 4 ]. In the present case, the metastatic lesion has been presumed to develop in the gingival tissue of the symphysis.…”

Section: Case Presentationmentioning

confidence: 99%

“…In the oral cavity, hard tissues such as the jawbone are more commonly affected than soft tissues such as the gingiva [ 3 ]. The gingivae (55 %) followed by the tongue (30 %) are the most common soft tissue sites affected by metastatic tumor [ 4 ]. Colonic carcinoma is one of the most common malignant neoplasms worldwide.…”

Section: Introductionmentioning

confidence: 99%

Metastatic rectal adenocarcinoma in the mandibular gingiva: a case report

et al. 2016

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BackgroundOral metastatic tumor from a rectal adenocarcinoma is very uncommon. The primary site is usually assumed based on the past clinical history. In the case of oral metastatic tumors, they commonly have a poor prognosis because often they have already spread to other sites.Case presentationWe present the case of a 64-year-old male patient with secondary metastasis to the mandibular gingiva via lung metastasis after the surgical resection of a primary rectal adenocarcinoma. The gingival lesion grossly appeared as a swollen mass, making mastication difficult. The patient received palliative radiotherapy for the mandibular mass lesion. However, tumor reduction was accompanied by the development of pneumonia and deterioration of the patient’s cachexia. Thus, the radiotherapy was discontinued but the patient died 2 months postradiotherapy. In the long term after its primary resection, the rectal adenocarcinoma was deduced to have finally metastasized to the oral region.ConclusionsIn this case, we consider a distant secondary metastasis to the oral region from a rectal malignancy. In such cases, careful clinical and pathologic evaluations are necessary, with careful consideration of the inclusion of palliative treatment in the therapeutic management.

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Metastatic Adenocarcinoma of the Colon: Early Manifestation in Gingival Tissue

Cited by 15 publications

References 13 publications

Colon cancer metastasis to the mandibular gingiva with partial occult squamous differentiation: A case report and literature review

Colon cancer metastasis to the mandibular gingiva with partial occult squamous differentiation: A case report and literature review

Primary Adenocarcinoma of the Colon with Metastases to the Mandible and Liver: A Case Report

Metastatic rectal adenocarcinoma in the mandibular gingiva: a case report

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