Adenocarcinoma With Signet Ring Cells of the Axilla Showing Apocrine Features: A Case Report

Kuno, Yoshinori; Numata, Tokio; Kanzaki, Tamotsu

doi:10.1097/00000372-199902000-00009

Cited by 31 publications

(44 citation statements)

References 10 publications

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“…In patients that present with positive regional lymph nodes, lymphadectomy, in addition to the removal of the primary, is common treatment among the PCAC literature [2,3,15,[20][21][22][23]. Radiotherapy may also provide additional benefit among those with regional lymph node metastases; however data is limited.…”

Section: Discussionmentioning

confidence: 99%

Treatment of primary cutaneous apocrine carcinoma of the scalp - case and review of the literature

Brown¹,

Riesco-Martinez²,

Petrella³

2016

Glob Dermatol

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A previously healthy 42 year-old woman presented at her family doctor after her hairdresser noticed a nodule in the left temporo-parietal area of the scalp. The mass was a firm, reddish nodule measuring approximately 3 × 2 cm. The patient was completely asymptomatic. She was referred to dermatology, and the lesion was excised. The initial pathology report showed a moderately-well differentiated adenocarcinoma. It was unclear at this time whether this was a primary lesion of the sweat gland or metastatic adenocarcinoma from another site. She was then referred to our centre for oncologic work-up.The pathology was reviewed and confirmed a moderately differentiated adenocarcinoma (Figure 1). The tumour was formed by single tubules or complex back to back tubular structures with areas where the luminal cells showed apical snouts. The lesion filled the reticular dermis without involving the epidermis. No perineural or lymphovascular invasion was present. The resection margins were clear, with the closest margin at 2 mm. The immunohistochemistry showed positivity for CK 7, ER, PR, Androgen receptor, CDX2, Ber ep4 and EMA. It was found to be negative for High molecular weight keratin, CK 20, COX2, CDX2, TTF1, Renal cell marker, CD 117, and CEA. It was concluded that this profile was most consistent with a metastatic breast carcinoma; however an eccrine/apocrine carcinoma of the skin could not be completely ruled out.On physical examination, there was no palpable lymphadenopathy of the neck, supraclavicular or infraclavicular regions bilaterally. No pre-or postauricular lymphadenopathy. On the left temporal parietal scalp, there was a 3 cm, well-healed scar, with no signs of infection or IntroductionPrimary cutaneous apocrine carcinoma (PCAC) is a rare type of sweat gland neoplasm with incidence rates estimated to range from 0.0049-0.0173 per 100,000 patients per year [1]. Approximately 200 total cases are reported in the literature. PCAC occurs in areas with large numbers of apocrine glands [2]. The scalp is among one of the rarest sites of occurrence, while the axilla appears most commonly [3]. Among the 186 cases reviewed by Hollowell, equal distribution was present in both males and females, with 76% of the sample population of Caucasian ethnicity. Median age was calculated at 67 years for this sample, which is the largest cohort studied to date [1].PCAC can develop in the dermal and subcutaneous layers of the skin, occasionally infiltrating the epidermal layer resulting in ulceration. PCAC has a diverse presentation, occurring as both uniand multi-nodular growths with varying colour [2]. Often these neoplasms are indurated, painless masses and can be associated with benign lesions [2], including a nevus sebaceous, most commonly seen with scalp lesions [4][5][6]. Development of these lesions typically occurs within a year before diagnosis [7]; however several cases have reported longer durations with a period of rapid growth [4,5,8,9]. PCAC is often quite difficult to differentiate from metastases of adenocarcinoma o...

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Section: Discussionmentioning

confidence: 99%

Treatment of primary cutaneous apocrine carcinoma of the scalp - case and review of the literature

Brown¹,

Riesco-Martinez²,

Petrella³

2016

Glob Dermatol

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“…The most common site in which CADC developed was the axilla. The 10 CADC cases described by Warkel and Helwig [2]involved the axilla, as well as 18 other cases from the literature [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14]. Five cases developed on the scalp, 4 [16]were associated with sebaceous nevus and 1 [5]with cylindroma.…”

Section: Discussionmentioning

confidence: 99%

“…Some tumors [1, 5, 8, 21our case , 1]that had been present for many years began to grow rapidly. Eleven cases [1, 3, 5, 7, 12, 13, 14, 16, 17, 18, 21]showed local recurrence and 17 cases [1, 3, 4, 5, 6, 10, 11, 12, 13, 14, 16, 17, 18, 21]exhibited regional lymph node or other organ metastases. All except 1 case [1]underwent whole-tumor excision or tumor excision with lymph node resection.…”

Section: Discussionmentioning

confidence: 99%

“…All except 1 case [1]underwent whole-tumor excision or tumor excision with lymph node resection. The cases [6, 7, 11, 12, 13, 14, 16, 18, 21, 23]received additional radiation therapy and chemotherapy [13, 14](tamoxifen, bleomycin) as adjuvant treatment. Only 1 case [1], which showed metastasis of the axillary lymph node, lung and bone, was treated with radiation therapy alone.…”

Section: Discussionmentioning

confidence: 99%

“…They occur most frequently in the axilla [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14]but are occasionally found in other areas, such as in the anogenital area [15], nipple [1], scalp [5, 16], face [17], trunk [1, 18], acral sites [1, 2, 4, 5, 6, 7, 8, 10, 18, 19, 20], wrist [21], fingertip [22]and lip [23]. Their histological and clinical features are poorly defined because of their rarity.…”

Section: Introductionmentioning

confidence: 99%

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Two Cases of Cutaneous Apocrine Ductal Carcinoma of the Axilla

Katagiri

Ansai

1999

Dermatology

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We report 2 cases of cutaneous apocrine ductal carcinoma (CADC) of the axilla in a 64- and a 54-year-old male. Histological examination revealed 2 solid, ductal and glandular tumors with decapitation secretion. Tumor cells showed cellular and nuclear atypism, and infiltrative growth of tumor cell nests was also observed. Although there were no characteristic features of extramammary Paget’s disease on the overlying skin, case 1 exhibited a typical Paget’s phenomenon. We concluded that the Paget’s phenomenon of case 1 was a result of upward extension of the tumor in the dermis. The neoplastic cells of both cases were immunohistochemically positive for gross cystic disease fluid protein, lysozyme, CD15 and carcinoembryonic antigen but negative for S-100 protein. Based on these findings, we concluded that these tumors were cutaneous apocrine ductal carcinomas. There was no evidence of tumor remnants in the axilla, and the patients have shown no signs of local recurrence or metastasis. We also reviewed the literature and summarize here the clinical features of CADC.

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Primary Cutaneous Signet Ring Cell Carcinoma

Requena

Sangüeza

2017

Cutaneous Adnexal Neoplasms

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Adenocarcinoma With Signet Ring Cells of the Axilla Showing Apocrine Features: A Case Report

Cited by 31 publications

References 10 publications

Treatment of primary cutaneous apocrine carcinoma of the scalp - case and review of the literature

Treatment of primary cutaneous apocrine carcinoma of the scalp - case and review of the literature

Two Cases of Cutaneous Apocrine Ductal Carcinoma of the Axilla

Primary Cutaneous Signet Ring Cell Carcinoma

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