Adenoid Cystic Carcinoma of Bartholin’s Gland Misdiagnosed as Benign Vulvar Adnexal Tumour

Makhija, Aman; Desai, Ajesh; Patel, Bijal; Parekh, Chetana

doi:10.1007/s40944-017-0173-6

Cited by 5 publications

(5 citation statements)

References 5 publications

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“…In the literature, the total doses applied were reported to range from 50.4 to 63 Gy. Agolli et al applied a total of 56 Gy in 28 fractions, Makhija et al a total of 50.4 Gy in 28 fractions, Momeni et al a total of 50.4 Gy in 30 fractions, and Goh et al a total of 63 Gy in 33 fractions [ 17 – 20 ]. Special considerations in the indication of adjuvant radiation therapy have to be made for premenopausal women who want to continue childbearing.…”

Section: Discussionmentioning

confidence: 99%

“…Radiotherapy has been used as an adjuvant treatment for ACC of Bartholin’s gland. It is particularly recommended when resection margins are positive or there is perineural invasion [ 2 , 5 – 7 , 13 , 15 – 17 ]. Bernstein et al suspected that ACC of Bartholin’s gland may be less sensitive to radiation therapy, because all of their reported patients with positive surgical margins died due to distant metastasis despite receiving adjuvant radiation treatment [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…Another patient received 6 cycles of palliative chemotherapy with cyclophosphamide, adriamycin, and cisplatin, but liver metastasis occurred shortly thereafter [ 25 ]. Further chemo-therapeutic agents that have been used in the therapy of ACC of Bartholin’s gland include paclitaxel, methotrexate, doxorubicin, 5-fluorouracil, dactinomycin, chlorambucil, and irinotecan [ 7 , 12 , 16 , 17 , 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

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Adenoid Cystic Carcinoma of Bartholin’s Gland: A Case Report with Emphasis on Surgical Management

2022

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Patient: Female, 42-year-old Final Diagnosis: Adenoid cystic carcinoma of the Bartholin’s gland Symptoms: Dispareunia • foreign body sensation in the vagina • palpable mass in the vagina • vaginal pain Medication: — Clinical Procedure: — Specialty: Obstetrics and Gynecology Objective: Rare disease Background: Adenoid cystic carcinomas of Bartholin’s gland are rare among gynecological malignancies, accounting for 0.1% to 7% of vulvar carcinomas and 0.001% of all female genital tract malignancies. There are no specific guidelines regarding treatment recommendations; therefore, they are commonly treated like vulvar cancer. Case Report: We present the case of a 42-year-old premenopausal woman with an adenoid cystic carcinoma of Bartholin’s gland diagnosed upon biopsy of a palpable, predominantly vaginally located mass causing foreign-body sensation, vaginal pain, and extreme dyspareunia. The adenoid cystic carcinoma of Bartholin’s gland was treated by radical resection in an extensive interdisciplinary surgical approach including bilateral inguinal lymph node dissection, partial posterior colpectomy, amputation of the rectum, and creation of a descendostomy, as well as reconstruction of the vagina and defect coverage using flap plastic. Conclusions: With the presentation of this case, we propose a possible therapeutic approach to adenoid cystic carcinomas of Bartholin’s gland with emphasis on surgical management. Especially in young patients, we recommend primary radical surgery with the objective to obtain negative resection margins. However, additional data on the adenoid cystic carcinoma of Bartholin’s gland is needed to better understand its biological behavior and thus optimize and standardize treatment. The role of systematic inguinal-femoral lymphadenectomy and adjuvant and neoadjuvant treatment modalities need further evaluation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Adenoid Cystic Carcinoma of Bartholin’s Gland: A Case Report with Emphasis on Surgical Management

2022

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“…It is recommended especially in patients with positive margins on resection [24, 25]. Previous case reports [12, 26–28] have reported radiotherapy doses ranging from 50.4 Gy to 66 Gy [27]. Extrapolating from Head and Neck adenoid cystic carcinoma series, it is worthwhile to rule out gross perineural invasion and to treat the entire grossly involved nerve [3, 29–31].…”

Section: Discussionmentioning

confidence: 99%

Adenoid Cystic Carcinoma of the Bartholin’s Gland: A Diagnostic Dilemma

Leow

Naing

et al. 2019

Case Reports in Obstetrics and Gynecology

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Adenoid cystic carcinomas of the Bartholin’s gland are extremely rare and are often misdiagnosed. There are currently no definite treatment guidelines. This article describes the case of a 33-year-old female who was managed at our centre for adenoid cystic carcinoma of the Bartholin’s gland. She presented with a prolonged history of a vulvar lesion which was eventually diagnosed as adenoid cystic carcinoma of the Bartholin’s gland. She was subsequently treated with wide local excision of the primary and inguinal lymph node dissection followed by adjuvant radiotherapy and chemotherapy. She had gross perineural invasion on MRI imaging. The present case highlights the diagnostic dilemma in this extremely rare cancer and the literature further explores the natural history and treatment options.

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“…Clinically, an enlargement in the greater vestibular glands in postmenopausal women should raise suspicion of the presence of a tumor, and biopsy is recommended. ACC presents as a not friable mass on speculum examination, with a size ranging from 0.5 to 4 cm, and with a deeply infiltrative pattern of growth [7,[16][17][18][19][20][21][22][23][24][25][26][27][28][29].…”

Section: Diagnosismentioning

confidence: 99%

Adenoid Cystic Carcinoma of Bartholin’s Gland: What Is the Best Approach?

et al. 2020

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Background and summary: Among all vulvar cancers, primary adenoid cystic carcinoma (ACC) of Bartholin's gland is a very rare tumor characterized by a slow growth, a high local aggressiveness, and a remarkable recurrence rate. Due to its rarity, treatment remains a challenge for oncologists and gynecological surgeons. Key message: The present paper reports clinical, radiological, and histological features of ACC of Bartholin's gland and reviews the literature data on the treatment options with a particular focus on the potential role of particle radiation therapy.

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Adenoid Cystic Carcinoma of Bartholin’s Gland Misdiagnosed as Benign Vulvar Adnexal Tumour

Cited by 5 publications

References 5 publications

Adenoid Cystic Carcinoma of Bartholin’s Gland: A Case Report with Emphasis on Surgical Management

Adenoid Cystic Carcinoma of Bartholin’s Gland: A Case Report with Emphasis on Surgical Management

Adenoid Cystic Carcinoma of the Bartholin’s Gland: A Diagnostic Dilemma

Adenoid Cystic Carcinoma of Bartholin’s Gland: What Is the Best Approach?

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