Adenoid cystic carcinoma (AdCC) is a malignant tumor mostly occurring in the head and neck salivary glands. In this article, two rare cases of adenoid cystic carcinoma occurring in the buccal mucosa with their treatment and long-term follow-up are presented. Adenoid cystic carcinoma (AdCC) was initially described as "cylindroma" in 1856 by Billroth, as it contained long amorphous compartments named "cylinders" in its histological view. Later on, the term "adenoid cystic carcinoma"(AdCC) replaced the term cylindroma for defining this tumor. 1 AdCC accounts for 10% of salivary gland tumors and for approximately 1% of all malignancies of the head and neck. 2 AdCC arises more frequently in minor salivary glands, in comparison with major salivary glands. 3 AdCC of minor salivary glands is believed to have a worse prognosis, compared to those of the major salivary glands. Pain can be a paramount symptom of the disease, due to the tumor's proneness toward perineural invasion. 4 Although this tumor is likely to occur at almost any age, it is most commonly observed in women, in the 5th and 6th decades of life. 5 In a recent study, the AdCC occurrence rate in women and men was 60:40, respectively. 6 AdCC often manifests itself as a small and slowly growing tumor. However, it is diagnosed at an advanced stage in