Adenoid cystic carcinoma of lung: a very unusual presentation

Kumari, Saroj; Saugat, Rajendra; Kapoor, Akhil; Paramanandhan, Murali; Soni, Gunjan; Sirohi, Parmender

doi:10.18203/issn.2454-2156.intjscirep20150225

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“…[13] The large airways are most commonly involved in over 80% of cases. [14] Our study included two cases of pulmonary ACC one of which was located peripherally and yielded hemorrhagic smears of FNAC. The second case of pulmonary ACC was located along the main bronchus, and CT-guided FNA smears were diagnostic of ACC.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Correlation of Adenoid Cystic Carcinoma: A Notorious Masquerader and Clinical Paradox

Sharma

Jha

Mandal

2018

Indian Journal of Medical and Paediatric Oncology

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Background: Adenoid cystic carcinoma (ACC) is an uncommon tumor with nonspecific clinicoradiological features thereby masquerading other nonneoplastic and neoplastic entities. Materials and Methods: Cases of ACC were retrospectively reviewed over a period of 4 years. The clinical details of these patients including fine-needle aspiration cytology (FNAC) and imaging findings were retrieved. Diagnosis was confirmed on histomorphology and supplemented with immunohistochemistry (IHC). Results: : Thirty cases of ACC were included in the study. Mean patient age was 55.5 years with a slight female preponderance. Among the 30 ACCs, 10 (33.4%) were located in submandibular gland, 7 (23.4%) in parotid gland, 6 (20%) in sublingual gland, 2 (6.7%) in lung and one each (3.33%) in nasal cavity, breast, cervix, lip, and skin of face. Preoperative imaging was suggestive of malignancy in 29 cases while a single case of parotid gland ACC was misdiagnosed as benign salivary gland neoplasm. FNAC was performed in 29 cases with a diagnostic accuracy of 82.7%. Histopathological examination showed characteristic features of ACC in all cases with perineural invasion seen in 7 cases. On IHC, positivity for cytokeratin was seen in all cases, cluster of differentiation 117 in 24 cases, thyroid transcription factor-1 in two cases and human epidermal growth factor receptor/neu in two cases. All cases were negative for estrogen receptor and progesterone receptor IHC. Mean Ki-67 score was 47.8%. Conclusion: ACCs are notorious tumors showing slow growth kinetics with propensity for perineural invasion, late recurrences, and distant metastasis. It should be kept in mind as a differential diagnosis at unusual sites other than salivary glands.

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Section: Discussionmentioning

confidence: 99%