Adenoid cystic carcinoma of the esophagus

Jacobsohn, W Z; Libson, Y.; Dollberg, L

doi:10.1016/s0016-5107(80)73286-8

Cited by 9 publications

References 12 publications

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Carcinoma of the esophagus with adenoid cystic differentiation

Epstein

Sears

Tucker

et al. 1984

Cancer

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Adenoid cystic carcinoma of the esophagus is a relatively rare lesion which characteristically exhibits a clinically aggressive behavior. In spite of this aggressive nature, it is most often referred to as a counterpart of the more common adenoid cystic carcinoma of salivary gland origin, a comparatively indolent tumor. In this report, the clinical and pathologic findings in a series of six cases of esophageal adenoid cystic carcinomas are contrasted with those of typical salivary gland lesions, and also compared to similar tumors exhibiting “adenoid cystic” differentiation arising in other extrasalivary gland sites. It is concluded that the esophageal tumors, as well as certain similar lesions arising in other extrasalivary gland sites, represent a class of poorly differentiated basaloid neoplasms distinct both clinically and morphologically from the common adenoid cystic carcinoma of salivary gland origin. Cancer 53:1131‐1136, 1984.

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Carcinoma of the esophagus with adenoid cystic differentiation

Epstein

Sears

Tucker

et al. 1984

Cancer

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Adenoid cystic carcinoma of the esophagus. Complete response to combination chemotherapy

Petursson

1986

Cancer

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A 55-year-old man had adenoid cystic carcinoma of the esophagus metastatic to the lungs and right supraclavicular fossa. He was treated with local radiation therapy to the esophagus and supraclavicular fossa, followed by combination chemotherapy with doxorubicin, mitomycin C, and 5-fluorouracil (5-FU). After a modest initial response, disease progression was noted in the pulmonary nodules. He was then treated with cisplatin, cyclophosphamide, vincristine, and doxorubicin. After two cycles of this regimen, there was complete regression of his pulmonary nodules, which was sustained for 5 months. A review of 44 literature cases of esophageal adenoid cystic carcinoma contrasted with adenoid cystic carcinoma of salivary gland origin indicated that the esophageal adenoid cystic carcinomas have a high tendency to metastasize (76% of cases) and a much poorer prognosis, with only 23% 1-year survival rate. It was concluded that esophageal adenoid carcinoma is clinopathologically distinct from the salivary gland variant, and that combination chemotherapy may be an effective treatment modality for this cancer.

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Pathology of Carcinoma of the Esophagus

Liu¹,

Zhou²

1984

Carcinoma of the Esophagus and Gastric Cardia

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Adenoid cystic carcinoma of the esophagus

Cited by 9 publications

References 12 publications

Carcinoma of the esophagus with adenoid cystic differentiation

Carcinoma of the esophagus with adenoid cystic differentiation

Adenoid cystic carcinoma of the esophagus. Complete response to combination chemotherapy

Pathology of Carcinoma of the Esophagus

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