Adenoid cystic carcinoma of the trachea and bronchus – a clinicopathologic study with DNA flow cytometric analysis and oncogene expression

Lin, Chih Ming; Li, Anna Fen Yau; Wu, Li Hwa; Wu, Yu Chung; Lin, Fan-ching; Wang, Liang Shun

doi:10.1016/s1010-7940(02)00406-2

Cited by 14 publications

(11 citation statements)

References 16 publications

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“…Although an equal sex distribution was noted previously [17,18] , recent literature shows male predominance, as was seen in our series [3,19] . AdCC spreads commonly by direct extension, perineural invasion, or haematogenous metastasis, whereas lymph nodal metastasis is uncommon [20] .…”

Section: Discussionsupporting

confidence: 61%

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c-Myb Overexpression in Cytology Smears of Tracheobronchial and Pulmonary Adenoid Cystic Carcinomas

Vallonthaiel

Jain²,

Singh³

et al. 2016

Acta Cytologica

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Aims: Adenoid cystic carcinoma (AdCC) is a malignant epithelial neoplasm that occurs rarely in the lower respiratory tract (LRT). AdCC at various sites is associated with the novel fusion transcript MYB-NFIB, along with the overexpression of the Myb protein. The expression of the Myb protein in AdCC of the LRT has not been evaluated much. Study Design: Cases of AdCC of the LRT diagnosed on cytology or histology were retrieved from our institutional archives. c-Myb expression was analyzed on immunocytochemistry/immunohistochemistry (ICC/IHC) and was correlated with clinicopathological parameters. Results: Twenty-three samples of AdCC originating from the LRT were included in the study. Four cases were diagnosed on cytology, 3 of which had corresponding histology specimens. The remaining 19 cases had either biopsy or resection. Most of the patients presented with endobronchial mass. The mean age was 49.4 years and a male predominance was seen. ICC and IHC for c-Myb showed positivity in 75 and 59% of the cases, respectively. Western blot was used to validate IHC results. Conclusion: AdCC of the LRT is rare and hence poses diagnostic difficulty. Cytology smears can be utilized for c-Myb ICC. The presence of c-Myb immunopositivity in most cases may possibly make Myb a diagnostic biomarker and a therapeutic target for personalized treatment.

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Section: Discussionsupporting

confidence: 61%

“…Patients with AdCC of the LRT often present with cough, dyspnea, wheezing, or stridor, and are treated for upper respiratory tract infection or asthma for months before being diagnosed [17] .…”

Section: Discussionmentioning

confidence: 99%

c-Myb Overexpression in Cytology Smears of Tracheobronchial and Pulmonary Adenoid Cystic Carcinomas

Vallonthaiel

Jain²,

Singh³

et al. 2016

Acta Cytologica

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“…It is widely known that ploidy changes may play a role in the pathogenesis and the development of many different clinicopathological features of the neoplasms, but the actual mechanisms have not exactly determined and may be different in accordance with the organs and the cyto -and histopathological subtypes 14,15) . We performed a comparative study on the presence or the absence of the chromosomal aneuploidy in 28 cases of ADC with BAC pattern, 7 cases of benign lung diseases and 9 normal lung tissue samples.…”

Section: Discussionmentioning

confidence: 99%

Interphase Cytogenetic Analysis of Lung Adenocarcinomas With Bronchioloalveolar Pattern

Shimizu

Sugino

Chiba

2012

FJMS

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: Aneuploidy has been suggested as a marker for stratification of many neoplasms but its potential usefulness in adenocarcinoma (ADC) with bronchioloalveolar (BAC) pattern has not been well defined. We examined paraffin -embedded tissue sections from 28 cases of ADC with BAC pattern as well as 7 benign lung lesions and 9 normal lung tissue samples for chromosomal aneuploidy by in situ hybridization using digoxigenin -labelled probes for chromosomes 1 and X.Of the 28 ADC with BAC pattern, 17 (61%) were diploid and 11 (39%) were aneuploid. Of the 17 diploid cases, 7 (41%) were male and 10 (59%) were female and of the 11 aneuploid cases, 2 (18%) were male, 9 (82%) were female. Regarding the cell type, 24 (86%) were adenocarcinomas in situ (AIS) so called BAC and minimally invasive ADC (MIA), and 4 cases (14%) were invasive ADC. Of the 12 cases each of AIS and MIA, 9 (75%) and 8 (67%) had diploid pattern respectively. Of the 4 invasive ADC cases, all had aneuploid pattern. Seventeen cases (71%) with T1 tumor size (>0 mm 30 mm), had diploid and 4 cases (100%) with T2 tumor size (>30 mm 70 mm) had aneuploid pattern. Statistical analyses showed that nuclear diploidy was significantly correlated with AIS and MIA tumor types while aneuploidy correlated with invasive ADC type (P=0.025). Also a significant correlation was found between ploidy and tumor size (P=0.033).In conclusion, these findings suggest that DNA ploidy analysis provides useful information for the assessment of cellular kinetics and reflect histopathological subtypes in ADC with BAC pattern that are destined to behave aggressively.

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“…Grade I ACCs are comprised primarily of a glandular or cystic pattern, and show essentially no evidence of solid growth; grade II tumors show less than 30% solid growth; and grade III tumors exhibit solid growth in more than 30% of the tumor volume. 10,17,18 Although some studies in salivary gland ACC have shown a relationship between the histologic grade and subsequent prognosis, 17,19 -22 these findings have not always been supported in subsequent studies. 23,24 In ACCL, similar controversy exists, with some studies showing prognostic importance of the histologic grade, 2,4,10 whereas others found that histologic grade failed to predict clinical outcome reliably.…”

Section: Histologic Featuresmentioning

confidence: 99%

“…Affected patients are usually adults, with one study reporting patients ranging in age from 29 to 79 years (mean, 54 years), and with a fairly equal occurrence in men and women. [1][2][3][4][5][6][7][8][9][10][11][12][13][14] Adenoid cystic carcinoma of lung (ACCL) is usually centrally located in the trachea or proximal bronchi, and therefore patients typically present with signs and symptoms of bronchial obstruction or ulceration, including dyspnea, cough, wheezing, pneumonia, and/or hemoptysis. Peripherally located ACCL may be asymptomatic and is less common, 5,13 constituting only 10 to 15% of all ACCLs.…”

Section: Clinical Featuresmentioning

confidence: 99%

Adenoid Cystic Carcinoma of the Lung

Bennett

Mills

Wick

2004

Pathology Case Reviews

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Primary adenoid cystic carcinoma of lung (ACCL) represents one of a group of salivary-type tumors of lung, likely originating from submucosal seromucinous glands in the pulmonary bronchial tree. Although it comprises less than 1% of all primary lung carcinomas, ACCL is considered the second most common primary salivary-type tumor of lung, after mucoepidermoid carcinoma. Typically, patients with ACCL present at a younger age than those with other primary lung carcinomas, although the age range is broad and ranges from the second to eighth decades. ACCL shares histologic and immunophenotypic features with ACC of salivary gland location, and exhibits a similar infiltrative growth pattern with a propensity for perineural invasion. Treatment is primarily surgical, and therefore complete surgical resection, with negative bronchial surgical margins at intraoperative frozen section, is important for the possibility of cure.Key Words: salivary-type tumors of lung and bronchus, adenoid cystic carcinoma, mucoepidermoid carcinoma (Pathology Case Reviews 2004;9: 253-258) CASE REPORTA 38-year-old woman, a nonsmoker, presented initially with complaints of chronic cough of 3 years duration. In the course of her evaluation, imaging revealed a 5 ϫ 6 cm right upper lobe lung mass involving the right mainstem bronchus. Bronchial brushings and washings demonstrated scattered groups of atypical mucinous-type cells, few papillary clusters of epithelial cells with rare groups of atypical cells, and few groups of markedly atypical cells. A bronchial biopsy and second bronchial brushing were both interpreted as adenoid cystic carcinoma (ACC; Fig. 1).A right total pneumonectomy was performed, and gross examination demonstrated a 4 ϫ 4 cm gray-white solid tumor in the right upper lobe involving the bronchus and abutting but not extending through the pleura. An intraoperative frozen section of the bronchial margin was positive for ACC, and reexcision of additional right upper lobe tissue and bronchus was negative for tumor on the final permanent sections. Eleven regional lymph nodes were also negative for tumor.Microscopic examination showed tumor surrounding the bronchus, extending and infiltrating into the pulmonary parenchyma (Fig. 2). Variable architectural patterns included cribriform areas and solid nests of basaloid-appearing cells with intervening collagenous stroma. The cribriform areas contained 2 types of spaces: true duct-like spaces lined by cuboidal cells with eosinophilic cytoplasm and so-called pseudocystic spaces with no true ductal lining cells. The latter consisted of cylindric spaces surrounded by cells with amphophilic cytoplasm and oval to angular nuclei. Some of the pseudocystic spaces were filled with eosinophilic basement membrane-like material, and others contained slightly basophilic mucinous-appearing material. Extensive perineural involvement and lymphovascular space invasion were identified. Mitotic figures were rare, and necrosis was absent.The patient received postoperative radiation treatment. After a 7-year ...

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Adenoid cystic carcinoma of the trachea and bronchus – a clinicopathologic study with DNA flow cytometric analysis and oncogene expression

Cited by 14 publications

References 16 publications

c-Myb Overexpression in Cytology Smears of Tracheobronchial and Pulmonary Adenoid Cystic Carcinomas

c-Myb Overexpression in Cytology Smears of Tracheobronchial and Pulmonary Adenoid Cystic Carcinomas

Interphase Cytogenetic Analysis of Lung Adenocarcinomas With Bronchioloalveolar Pattern

Adenoid Cystic Carcinoma of the Lung

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