Adenoid cystic carcinoma of the supraglottic larynx: Report of a case and review of the literature

Stillwagon, Gary B.; Smith, Robert R.; Highstein, Charles; Lee, Ding‐Jen

doi:10.1016/s0196-0709(85)80060-0

Cited by 14 publications

(13 citation statements)

References 15 publications

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“…The symptoms depend on its location; for example, a subglottic lesion may result in dyspnea and a glottic or supraglottic lesion may cause hoarseness. Neck pain is also a characteristic symptom of ACC caused by perineural invasion 2 . Pathophysiologically, ACC is a neoplasm that originates in the subepithelial gland and spreads submucosally 4 .…”

Section: Discussionmentioning

confidence: 99%

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Adenoid cystic carcinoma of the supraglottis mimicking a laryngeal cyst

Lee

Fang

et al. 2003

Otolaryngol.--head neck surg.

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Laryngeal cysts are usually benign, frequently occurring in the supraglottis. 1 Most have no clinical significance. Nonetheless, hoarseness, a lump in the throat, and pain are sometimes reported. 1 The clinician should pay attention to the location of a cystic lesion of the larynx. We report a case of adenoid cystic carcinoma (ACC) on the laryngeal surface of the epiglottis mimicking a laryngeal cyst. ACC of the larynx is an infrequently encountered neoplasm that makes up less than 0.25% of all laryngeal carcinomas. 2 The sites of origin, in descending order, are the subglottis, the supraglottis, and the true glottis. 2Otolaryngology-Head and Neck Surgery 158 LEE et al

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Section: Discussionmentioning

confidence: 99%

“…We report a case of adenoid cystic carcinoma (ACC) on the laryngeal surface of the epiglottis mimicking a laryngeal cyst. ACC of the larynx is an infrequently encountered neoplasm that makes up less than 0.25% of all laryngeal carcinomas 2 . The sites of origin, in descending order, are the subglottis, the supraglottis, and the true glottis 2 …”

mentioning

confidence: 99%

Adenoid cystic carcinoma of the supraglottis mimicking a laryngeal cyst

Lee

Fang

et al. 2003

Otolaryngol.--head neck surg.

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“…There is, however, an uncertain number of reports of AdCC prior to that date, which today, according to the histological description, very likely would have been classified as AdCC-HGT. As an example, the 1985 report by Stillwagon et al [ 50 ] would fit as AdCC-HGT: “Histologically, the tumor was an adenoid cystic carcinoma with cribriform and solid areas as well as some areas of undifferentiated carcinoma”. For obvious reasons, it is impossible to review all single case reports of AdCC in the literature to document possible cases of AdCC-HGT and, therefore, only cases classified as AdCC-HGT or dedifferentiated AdCC, published after 1999 have been included in this review and are summarized in Table 1 .…”

Section: Reviewmentioning

confidence: 99%

Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review

et al. 2016

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Adenoid cystic carcinoma (AdCC) is among the most common malignant tumors of the salivary glands. It is characterized by a prolonged clinical course, with frequent local recurrences, late onset of metastases and fatal outcome. High-grade transformation (HGT) is an uncommon phenomenon among salivary carcinomas and is associated with increased tumor aggressiveness. In AdCC with high-grade transformation (AdCC–HGT), the clinical course deviates from the natural history of AdCC. It tends to be accelerated, with a high propensity for lymph node metastasis. In order to shed light on this rare event and, in particular, on treatment implications, we undertook this review: searching for all published cases of AdCC-HGT. We conclude that it is mandatory to perform elective neck dissection in patients with AdCC-HGT, due to the high risk of lymph node metastases associated with transformation.Electronic supplementary materialThe online version of this article (doi:10.1007/s12325-016-0298-5) contains supplementary material, which is available to authorized users.

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“…These changes may be focal within the tumor and, as a result, AdCC-HGT may not always be appreciated pre-operatively. AdCC-HGT is an aggressive tumor with a high tendency to recur and metastasize to the lymph nodes (at least 50% or higher) and distant organs [ 120 ], as illustrated by the supraglottic tumor reported by Stillwagon et al [ 52 ], which metastasized to five cervical lymph nodes with extracapsular extension, as well as to the liver, bone marrow, brain, heart, lungs and kidneys. AdCC-HGT must therefore be treated aggressively with due consideration for neck dissection.…”

Section: Treatment Suggestionsmentioning

confidence: 99%

Cervical Lymph Node Metastasis in Adenoid Cystic Carcinoma of the Larynx: A Collective International Review

et al. 2016

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Adenoid cystic carcinoma (AdCC) of the head and neck is a well-recognized pathologic entity that rarely occurs in the larynx. Although the 5-year locoregional control rates are high, distant metastasis has a tendency to appear more than 5 years post treatment. Because AdCC of the larynx is uncommon, it is difficult to standardize a treatment protocol. One of the controversial points is the decision whether or not to perform an elective neck dissection on these patients. Because there is contradictory information about this issue, we have critically reviewed the literature from 1912 to 2015 on all reported cases of AdCC of the larynx in order to clarify this issue. During the most recent period of our review (1991–2015) with a more exact diagnosis of the tumor histology, 142 cases were observed of AdCC of the larynx, of which 91 patients had data pertaining to lymph node status. Eleven of the 91 patients (12.1%) had nodal metastasis and, based on this low proportion of patients, routine elective neck dissection is therefore not recommended.

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Adenoid cystic carcinoma of the supraglottic larynx: Report of a case and review of the literature

Cited by 14 publications

References 15 publications

Adenoid cystic carcinoma of the supraglottis mimicking a laryngeal cyst

Adenoid cystic carcinoma of the supraglottis mimicking a laryngeal cyst

Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review

Cervical Lymph Node Metastasis in Adenoid Cystic Carcinoma of the Larynx: A Collective International Review

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