Adenoid cystic carcinoma of the paranasal sinuses: Retrospective series and review of the literature

Gautier, Michel; Joubert, M.; Delemazure, A.S.; Espitalier, F.; Durand, Nicolas; Malard, O.

doi:10.1016/j.anorl.2012.09.010

Cited by 63 publications

(80 citation statements)

References 21 publications

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“…Knowledge of the prevalence of primary tumor locations aids in the diagnosis and treatment of disease. Common presenting symptoms of SNACC include maxillary pain/pressure, unilateral nasal blockage, and recurrent epistaxis . Consistent with other studies, including large database analyses, this study found that SNACCs most commonly occur within the maxillary sinus (49.7%) followed by the nasal cavity (32.4%) .…”

Section: Discussionsupporting

confidence: 90%

“…Common presenting symptoms of SNACC include maxillary pain/pressure, unilateral nasal blockage, and recurrent epistaxis . Consistent with other studies, including large database analyses, this study found that SNACCs most commonly occur within the maxillary sinus (49.7%) followed by the nasal cavity (32.4%) . It is thus important to assess for perineural invasion for all maxillary sinus tumors (eg, cheek numbness) due to the predilection of SNACC to track along the infraorbital nerve.…”

Section: Discussionsupporting

confidence: 86%

“…In this study, we used the National Cancer Database (NCDB) to analyze overall survival (OS) as it relates to patients’ demographics as well as tumor characteristics and treatments rendered. This database analysis builds upon existing single‐institution case reports and population data analyses to add additional cases to the literature and examine the factors, including treatment sequence, associated with all‐cause mortality in patients with SNACC …”

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confidence: 99%

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Adenoid cystic carcinoma of the sinonasal tract: a review of the national cancer database

Trope

Triantafillou

Kohanski

et al. 2019

Int Forum Allergy Rhinol

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Background: Sinonasal adenoid cystic carcinoma (SNACC) is a rare malignancy with a propensity for distant metastasis. In this study we describe the incidence and determinants of survival among patients with SNACC between the years 2004 and 2012 using the National Cancer Database (NCDB). Methods:This was a retrospective, population-based cohort study performed at a tertiary academic medical center. All participants were diagnosed with SNACC between 2004 and 2012 within the NCDB. The main outcome was overall survival (OS). Results:A total of 793 patients were identified. The cohort was composed of 46.9% males. Mean age at diagnosis was 59.6 years. The maxillary sinus was the most common primary site (49.7%). Nodal disease was seen in 3.6% of the patients, whereas 3.7% had distant metastases. Stage IV disease was seen in 49.1% of cases. In total, 77.4% of patients underwent surgery, 68.2% received radiation therapy, and 16.4% had chemotherapy. Median OS was 78.5 months; OS at 1, 2, and 5 years was 91%, 83%, and 61%, respectively. On multivariate analysis, advanced age (p = 0.001), frontal sinus primary site (p < 0.001), positive margins (p < 0.001), Charlson comorbidity index >0 (p = 0.01), residing in an urban se ing (p = 0.04), poorly differentiated or undifferentiated tumor grade (p = 0.003), and advanced tumor stage (p = 0.01) were associated with worse OS, whereas surgery (p < 0.001), but not radiation therapy (p = 0.52) or chemotherapy (p = 0.57), predicted improved OS. Conclusion:Predictors of survival in SNACC include age, comorbidity status, grade, and stage. Surgery is associated with improved survival and remains the mainstay of therapy, whereas the roles of radiation therapy and chemotherapy require future investigation. C 2019 ARS-AAOA, LLC.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 86%

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confidence: 99%

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Adenoid cystic carcinoma of the sinonasal tract: a review of the national cancer database

Trope

Triantafillou

Kohanski

et al. 2019

Int Forum Allergy Rhinol

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“…In sinonasal ACC, 5-year disease-free survival ranges from 43% to 58%. [35][36][37] The fact that all our cases, except case 1, were treated within the last 4 years limits our ability to draw conclusions regarding the prognosis for these patients as well as for the optimal treatment. Despite this, it is noteworthy that none of these patients developed recurrences.…”

Section: Discussionmentioning

confidence: 99%

Human papillomavirus‐related carcinoma with adenoid cystic‐like features of the sinonasal tract: clinical and morphological characterization of six new cases

et al. 2017

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“…Adenoid cystic carcinoma is a rare malignant tumour, accounting for 1-2% of all sinonasal malignant tumours & representing < 0.15% of all malignant head and neck tumours, regardless of site and histology [1, 2]. …”

Section: Introductionmentioning

confidence: 99%

Sinonasal adenoid cystic carcinoma-role of on-site FNAC: a case report

Santosh

Kothari

Patil

et al. 2018

BMC Ear Nose Throat Disord

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BackgroundAdenoid cystic carcinoma (ACC), a rare tumor of epithelial cell origin, commonly arises from the major salivary glands. Uncommonly it may be found outside the salivary glands and it's especially rare in the nasal cavity.Case presentationA 71-year female had complaints of swelling at the base of nose, Fine needle aspiration (FNA) from the swelling revealed features of adenoid cystic carcinoma; cell block & IHC for CD-117 was positive.ConclusionsSino-nasal ACC (SNACC) continues to pose diagnostic and therapeutic challenges to clinicians. Due to its rarity & vague presentation, early diagnosis requires a high index of suspicion. FNA can be used as an invaluable diagnostic tool in the evaluation of these lesions. Since it’s incidence in sinonasal region is rare; our attempt to report this case will heighten the physician’s awareness of this disease, helping further treatment.

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Adenoid cystic carcinoma of the paranasal sinuses: Retrospective series and review of the literature

Cited by 63 publications

References 21 publications

Adenoid cystic carcinoma of the sinonasal tract: a review of the national cancer database

Adenoid cystic carcinoma of the sinonasal tract: a review of the national cancer database

Human papillomavirus‐related carcinoma with adenoid cystic‐like features of the sinonasal tract: clinical and morphological characterization of six new cases

Sinonasal adenoid cystic carcinoma-role of on-site FNAC: a case report

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