Adenoid Cystic Carcinoma of Vulva-11 Years’ Single-Institution Experience

Johnson, Leena Rose; Nair, Rema Prabhakaran; Suchetha, S.; Mony, Rari P.; Gangadharan, Jayapriya; Kumar, Aswin; Ahamed, Iqbal M.

doi:10.1007/s13224-016-0935-6

Cited by 11 publications

(20 citation statements)

References 15 publications

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“…Because of the slow growth, the rarity and the lack of specific symptoms, ACCs of the Bartholin gland are often initially mistaken for cysts. Due to the delayed diagnosis, patients with vulvar ACC often present with locally advanced disease [3]. ACC of the Bartholin gland can invade the vaginal wall, ischio-rectal fossa, and even the pubic bone, which often prevents complete surgical removal of the lesion [6].…”

Section: Discussionmentioning

confidence: 99%

“…Adenoid cystic carcinoma (ACC) is a rare variant of an adenocarcinoma, which can arise in any organ with seromucinous or sweat glands. Although most common in the major and minor salivary glands, ACC has also been reported to occur in the skin, the lacrimal glands, the breast, the oesophagus, the upper and lower respiratory tract and the female genital tract [1][2][3]. In the vulva, ACC usually originates from the Bartholin gland [3].…”

Section: Introductionmentioning

confidence: 99%

“…Although most common in the major and minor salivary glands, ACC has also been reported to occur in the skin, the lacrimal glands, the breast, the oesophagus, the upper and lower respiratory tract and the female genital tract [1][2][3]. In the vulva, ACC usually originates from the Bartholin gland [3]. Primary carcinomas of the Bartholin gland account for less than 5 % of all vulvar carcinomas and less than 1 % of all female genital tract malignancies [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Adenoid cystic carcinoma of the Bartholin gland is not HPV-related: A case report and review of literature

Boer

Dasgupta

Ewing‐Graham

et al. 2020

Pathology - Research and Practice

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Adenoid cystic carcinoma (ACC) of the Bartholin gland is a rare gynaecological entity. Despite its slow growth and inconspicuous presentation, vulvar ACC has a propensity for perineural invasion and is therefore associated with high local recurrence rates.We report a case of vulvar ACC in a 61-year-old woman with a prolonged swelling of the Bartholin gland. This patient presented with pulmonary metastases at the moment of histological diagnosis. The vulvar and the pulmonary lesions showed identical histology. Despite a history of human papilloma virus (HPV)-related usual type vulvar intra-epithelial neoplasia and cervical squamous cell carcinoma, the vulvar ACC was negative for both p16 immunohistochemistry and HPV-DNA.We conclude that HPV is not involved in the pathogenesis of pure ACC of the Bartholin gland. Additionally, we advocate a low threshold for performing biopsies of vulvar swellings in women aged > 40 years, to rule out malignancy and to prevent diagnostic delays.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Adenoid cystic carcinoma of the Bartholin gland is not HPV-related: A case report and review of literature

Boer

Dasgupta

Ewing‐Graham

et al. 2020

Pathology - Research and Practice

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“…Clinically, an enlargement in the greater vestibular glands in postmenopausal women should raise suspicion of the presence of a tumor, and biopsy is recommended. ACC presents as a not friable mass on speculum examination, with a size ranging from 0.5 to 4 cm, and with a deeply infiltrative pattern of growth [7,[16][17][18][19][20][21][22][23][24][25][26][27][28][29].…”

Section: Diagnosismentioning

confidence: 99%

Adenoid Cystic Carcinoma of Bartholin’s Gland: What Is the Best Approach?

et al. 2020

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Background and summary: Among all vulvar cancers, primary adenoid cystic carcinoma (ACC) of Bartholin's gland is a very rare tumor characterized by a slow growth, a high local aggressiveness, and a remarkable recurrence rate. Due to its rarity, treatment remains a challenge for oncologists and gynecological surgeons. Key message: The present paper reports clinical, radiological, and histological features of ACC of Bartholin's gland and reviews the literature data on the treatment options with a particular focus on the potential role of particle radiation therapy.

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“…Adenoid cystic carcinomas usually arise from minor and major salivary glands [3]. The other sites of origin include the nasopharynx [4], lacrimal glands [5], skin [6], trachea [7], breast [8], and vulva [9]. As of 2018 only 350 cases of the adenoid cystic subtype have been reported in the Bartholin's gland [10].…”

Section: Introductionmentioning

confidence: 99%

Adenoid Cystic Carcinoma of the Bartholin’s Gland: A Diagnostic Dilemma

Leow

Naing

et al. 2019

Case Reports in Obstetrics and Gynecology

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Adenoid cystic carcinomas of the Bartholin’s gland are extremely rare and are often misdiagnosed. There are currently no definite treatment guidelines. This article describes the case of a 33-year-old female who was managed at our centre for adenoid cystic carcinoma of the Bartholin’s gland. She presented with a prolonged history of a vulvar lesion which was eventually diagnosed as adenoid cystic carcinoma of the Bartholin’s gland. She was subsequently treated with wide local excision of the primary and inguinal lymph node dissection followed by adjuvant radiotherapy and chemotherapy. She had gross perineural invasion on MRI imaging. The present case highlights the diagnostic dilemma in this extremely rare cancer and the literature further explores the natural history and treatment options.

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Adenoid Cystic Carcinoma of Vulva-11 Years’ Single-Institution Experience

Abstract: Adenoid cystic carcinoma of vulva is an extremely rare, slowly progressing neoplasm mostly involving the Bartholin's gland. The usual treatment includes wide excision and adjuvant radiotherapy (if required). There may be late local and distant recurrence.

Cited by 11 publications

References 15 publications

Adenoid cystic carcinoma of the Bartholin gland is not HPV-related: A case report and review of literature

Adenoid cystic carcinoma of the Bartholin gland is not HPV-related: A case report and review of literature

Adenoid Cystic Carcinoma of Bartholin’s Gland: What Is the Best Approach?

Adenoid Cystic Carcinoma of the Bartholin’s Gland: A Diagnostic Dilemma

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