Adenoid cystic carcinoma: Use of cell proliferation, BCL-2 expression, histologic grade, and clinical stage as predictors of clinical outcome

Norberg‐Spaak, Lena; Dardick, Irving; Ledin, Torbjörn

doi:10.1002/1097-0347(200008)22:5<489::aid-hed8>3.0.co;2-x

Cited by 71 publications

(61 citation statements)

References 27 publications

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“…A correlation between a high ki67/MIB1 labelling index and the unfavourable prognosis of MEC has been reported, but for ACC some studies found ki67/MIB1 useful for predicting the biologic behaviour and/or treatment failure, while others found it not associated with morphology or clinical course of patients (6,10,11,38).…”

Section: Discussionmentioning

confidence: 99%

The proliferation marker Chromatin Assembly Factor-1 is of clinical value in predicting the biological behaviour of salivary gland tumours

Staibano

Mascolo²,

Rocco³

et al. 2010

Oncol Rep

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Abstract. Salivary gland tumours (SGT) constitute a diagnostically challenging group of neoplasms with frequently unpredictable clinical outcome. The proliferation rate facilitates the identification of aggressive SGT. The Chromatin Assembly Factor-1 (CAF-1) is a major epigenetic regulator of nuclear chromatin organization during DNA replication. It plays a critical function in human tumourigenesis and has been proposed as a new proliferation and prognostic marker for some malignancies. This study focused on the role of CAF-1/p60 protein as a marker of clinical value for SGT. The expression of CAF-1/p60 was evaluated by immunohistochemistry on a retrospective series of 362 surgically excised benign and malignant SGT with different histogenesis and, when available, on fine-needle pre-surgical cytological biopsies. The resulting data were compared with traditional prognostic parameters, including the expression of the routine proliferation marker ki67/MIB1. CAF-1/p60 was detectable in all SGT, with highest degree of expression in metastasizing malignant tumours. Moreover, the cases of benign tumours which progressed to carcinoma during the follow-up, showed significantly higher CAF-1/p60 expression than nonprogressing benign SGT, both on histological sections and cytological smears of the primary tumour. Cox's multiple regression analysis selected CAF-1/p60 expression as the best independent predictor of cancer development for benign SGT (p<0.0001), and the best independent predictor of metastasis onset for malignant tumours (p<0.0004). Overexpression of CAF-1/p60, on histological and/or cytological samples, characterizes malignant SGT with aggressive behaviour, irrespective of their specific histotype, and allows the early diagnosis of progression toward malignancy of morphologically benign tumours.

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Section: Discussionmentioning

confidence: 99%

The proliferation marker Chromatin Assembly Factor-1 is of clinical value in predicting the biological behaviour of salivary gland tumours

Staibano

Mascolo²,

Rocco³

et al. 2010

Oncol Rep

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“…Perineural invasion (not shown) was identified only in the resected specimen on tumor site, tumor stage, and microscopic tumor pattern. Tubular and cribriform subtypes have a better prognosis than solid subtypes [13,14]. in our case, microscopic examination revealed the classic cribriform pattern, which is considered low-grade (Grade I/III).…”

Section: Dıscussionmentioning

confidence: 94%

Unique presentation of adenoid cystic carcinoma in postcricoid region: a case report and review of the literature

Saraydaroğlu

Çoşkun

Kasap

2011

Head and Neck Pathol

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Malignant tumors of minor salivary glands are uncommon, representing only 2-4% of all head and neck malignancies. In the larynx, minor salivary gland tumors rarely occur and constitute less than 1% of laryngeal tumors. Most of the minor salivary gland tumors arise in the subglottis; however, they can also occur in the supraglottis in the false vocal cords, aryepiglottic folds, and caudal aspect of the epiglottis. The most common type of malignant minor salivary gland tumor is adenoid cystic carcinoma. In the last 20 years, only 40 cases of adenoid cystic carcinoma arising in variable locations of the larynx have been reported in the English language literature. We present a case of adenoid cystic carcinoma of the larynx arising in the inter-arytenoid and postcricoid region in a 54-year-old woman. To our knowledge, this is the first case of adenoid cystic carcinoma arising in this particular region of the larynx.

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“…Luna et al 14 reported a series of 26 patients with submandibular gland adenoid cystic carcinomas treated at The University of Texas M. D. Anderson Cancer Center (Houston, TX) and found that aneuploid tumors were associated with a higher likelihood of solid cytoarchitecture, lymph node metastases, and advanced stage. Norberg-Spaak et al 12 at the Linkö-ping University Hospital (Linköping, Sweden) analyzed MIB-1 positivity as an indicator of proliferation in a series of 31 patients and found that the mean percent of MIB-1 -positive cells significantly correlated with histologic grade: grade 1, 4.8%; grade 2, 8.0%; and grade 3, 20.2% ( p = .053). The likelihood of recurrence was significantly lower for patients with low MIB-1 positivity.…”

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confidence: 99%

Radiotherapy alone or combined with surgery for adenoid cystic carcinoma of the head and neck

et al. 2004

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Background. The purpose of this study was to analyze the results of radiotherapy (RT) alone or combined with surgery for adenoid cystic carcinoma.Methods. Between September 1966 and November 2001, 101 previously untreated patients were treated with curative intent with RT alone or combined with surgery. Follow-up ranged from 0.4 to 30.6 years (median, 6.6 years). All living patients had follow-up for at least 1 year.Results. The 5-and 10-year rates of local control were as follows: RT alone, 56% and 43%; surgery and RT, 94% and 91%; and overall, 77% and 69%. Multivariate analysis of local control revealed that T stage ( p = .0101) and treatment group ( p = .0008) significantly influenced this endpoint. The 5-and 10-year rates of distant metastases-free survival were 80% and 73%. The 5-and 10-year absolute survival rates were as follows: RT alone, 57% and 42%; surgery and RT, 77% and 55%; and overall, 68% and 49%. Multivariate analysis of absolute survival revealed that T stage ( p = .0043) and clinical nerve invasion ( p = .0011) significantly influenced this endpoint. The 5-and 10-year causespecific survival rates were as follows: RT alone, 65% and 48%; surgery and RT, 81% and 71%; and overall, 74% and 61%. Multivariate analysis revealed that T stage ( p = .0008) and clinical nerve invasion ( p = .0005) significantly influenced causespecific survival.Conclusions. The optimal treatment for patients with adenoid cystic carcinoma is surgery and adjuvant RT. A significant proportion of patients with incompletely resectable disease are cured after RT alone. Improvements in locoregional control are offset, in part, by the relatively high incidence of distant metastases.

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Adenoid cystic carcinoma: Use of cell proliferation, BCL-2 expression, histologic grade, and clinical stage as predictors of clinical outcome

Cited by 71 publications

References 27 publications

The proliferation marker Chromatin Assembly Factor-1 is of clinical value in predicting the biological behaviour of salivary gland tumours

The proliferation marker Chromatin Assembly Factor-1 is of clinical value in predicting the biological behaviour of salivary gland tumours

Unique presentation of adenoid cystic carcinoma in postcricoid region: a case report and review of the literature

Radiotherapy alone or combined with surgery for adenoid cystic carcinoma of the head and neck

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