Adenoma of the non-pigmented ciliary epithelium: A rare intraocular tumor with unusual immunohistochemical findings

Pecorella, Irene; Ciocci, Luciano; Modesti, Marina; Appolloni, Rossella

doi:10.1016/j.prp.2009.02.009

Cited by 13 publications

(3 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It showed no progression in size. Numerous high-reflective lesions such as leiomyoma [9,10], melanocytoma [9], medulloepithelioma [11], adenoma [12][13][14], pseudoepitheliomatous hyperplasia, haemangioma, and neurofibroma [9] were considered a differential diagnosis. Based on clinical findings and ultrasound characteristics, SED leiomyoma was established.…”

Section: Resultsmentioning

confidence: 99%

Possible role of standardized echography complementing ultrasound biomicroscopy in tumors of the anterior eye segment: a study in a series of 13 patients

et al. 2018

View full text Add to dashboard Cite

Purpose To evaluate the efficacy of standardized A-scan echography (ASE) complementing ultrasound biomicroscopy (UBM) to propose the most efficient method as grounds for the diagnosis, treatment, and follow-up of anterior eye-segment tumors. Methods The inclusion criteria were tumors of the ciliary body and peripheral choroidal tumors, whose anterior border could not be visualized with a 10 MHz ultrasound probe. The largest basal dimension and the highest prominence of the tumor were measured with a UBM Lin 50 probe. A standardized A-scan examination determined the tumor's thickness and internal reflectivity. Thus, tissue differentiation led to a standardized echography-based diagnosis (SED). Results The study included 13 patients. SED was achieved in all examined tumors. The smallest thickness of the tumor of the ciliary body enabling SED was only 1.78 mm. The highest prominence of the tumor (3.66 ± 1.39 mm) was generally larger than its thickness (3.30 ± 1.71 mm). Conclusion When approaching ciliary body tumors, both ASE and UBM should be performed, the former to accurately differentiate the tumor and measure its height, and the latter to delineate anterior tumor margins and iris involvement. Standardized echography-based diagnosis was grounds for further evaluation and/or treatment in this case series. The highest prominence of the ciliary body tumor perpendicular to the sclera as evidenced by UBM was generally higher than the thickness obtained with standardized echography. Hence, we propose ASE thickness to be the grounds for staging the severity of ciliary body tumors in the algorithm for their management. Keywords Radiation plaque treatment • Standardized ultrasonography • Tissue differentiation • Uveal tumors • Ultrasound biomicroscopy SOMMARIOObiettivo Valutare l'efficacia dell'ecografia standardizzata A-scan (ASE) integrandola con la biomicroscopia ad ultrasuoni (UBM) per proporre il metodo più efficiente come base per diagnosi, trattamento e verifica dei tumori del segmento oculare anteriore. Metodi Sono stati inclusi pazienti con tumori del corpo ciliare e tumori della coroide periferici il cui bordo anteriore non poteva essere visualizzato con la sonda ad ultrasuoni 10 MHz. La dimensione basale maggiore e la sporgenza più alta del tumore sono state misurate con la sonda UBM Lin 50. L'esame ecografico standardizzato A-scan è stato utilizzato per determinare lo spessore e la riflettività interna del tumore. Pertanto, la differenziazione del tessuto ha portato alla diagnosi basata sull'ecografia standardizzata (SED). Risultati Lo studio ha coinvolto 13 pazienti. La SED è stata effettuata in tutti i tumori esaminati. Lo spessore minimo del tumore del corpo ciliare rilevato dalla SED era di soli 1,78 millimetri. La sporgenza maggiore del tumore (3,66 ± 1,39 millimetri) era generalmente più grande del spessore del tumore (3,30 ± 1,71 millimetri). Conclusione Quando ci si approccia allo studio dei tumori del corpo ciliare si devono tenere in considerazione entrambi i metodi ASE e UBM, il primo per differenz...

show abstract

Section: Resultsmentioning

confidence: 99%

Possible role of standardized echography complementing ultrasound biomicroscopy in tumors of the anterior eye segment: a study in a series of 13 patients

et al. 2018

View full text Add to dashboard Cite

show abstract

“…In our case, the tumor was composed of solid and tubular components, but most of the tubular components were outside the iris, while most of the solid components were inside the iris. Adenoma of the NPCE shows negative immunoreactivity for HMB-45 and positive immunoreactivity for S-100 and vimentin in most cases [6, 12, 13, 14, 15]. In some cases, a positive reaction to CK (AE1/AE3) is detected [1, 6, 15], CD68 is focally positive [14] or negative [15], and the proliferation index (MIB-1, Ki-67) is below 10% [14, 15].…”

Section: Discussionmentioning

confidence: 99%

Rare Histological Type of Adenoma of the Nonpigmented Ciliary Epithelium

Ishiahara

Hashida

Asao

et al. 2019

Case Rep Ophthalmol

View full text Add to dashboard Cite

We report the rare case of an adenoma of the nonpigmented ciliary epithelium (NPCE). A 67-year-old healthy man presented with a regularly shaped and nonpigmented mass at the iris root of his right eye. His best-corrected visual acuity was 1.5 with normal intraocular pressure. During observation, the size of the tumor remained stable for 1.5 years but then rapidly grew, extending through the iris, and gradually enlarged to the point of compressing the iris. Ultimately, an iridocyclectomy with scleral resection under a lamellar scleral flap was performed. The histopathologic features of the resected tissue were consistent with adenoma of the NPCE. Histopathological analysis showed that the tumor consisted of both tubular and solid components. There were solid lesions inside of the ciliary epithelium and tubular lesions outside. We observed positive immunoreactivity to vimentin and cytokeratin CK (AE1/AE3) and negative reactivity to S-100 and CD68, both rarely associated with adenoma of NPCE. During 1 year of follow-up after the iridocyclectomy, no signs of tumor recurrence were observed.

show abstract

“…Melan-A immunoreactivity has however been reported in a human adenoma of the nonpigmented ciliary epithelium. 52 Although differentiation between iridociliary tumors and melanoma does not typically require immunohistochemistry, the immunoreactivity of Melan-A in the nonpigmented ciliary epithelium may pose a diagnostic challenge in rare cases of poorly differentiated neoplasms affecting the uveal tract. Investigation of the immunoreactivity of other melanocyte/melanoma markers, such as PNL2 and tyrosine-related proteins 1 and 2, 60,66 in normal and neoplastic ocular tissue might prove useful.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Characteristics of Normal Canine Eyes

Labelle¹,

Reilly

Naydan

et al. 2011

Vet Pathol

View full text Add to dashboard Cite

Immunohistochemistry is widely utilized in diagnostic laboratories to study neoplastic and nonneoplastic diseases. Knowledge of the immunohistochemical characteristics of normal tissue is essential for interpretation of immunoreactivity in pathologic conditions. In this study, immunohistochemistry was performed with a broad panel of diagnostically relevant antibodies on 4 normal canine globes--namely, vimentin, pan-cytokeratin (AE1/AE3), cytokeratin 7, cytokeratin 8/18, cytokeratin 20, α-smooth muscle actin, muscle specific actin, desmin, Melan-A, microphthalmia transcription factor, S-100, glial fibrillary acidic protein, triple neurofilaments, neuron-specific enolase, chromogranin A, synaptophysin, laminin and CD31. Results include cytokeratin immunoreactivity limited to the conjunctival epithelium, corneal epithelium, and retinal pigment epithelium; distinct patterns of immunopositivity of muscle markers; and widespread immunoreactivity for vimentin and most neural/neuroendocrine markers. These findings in normal eyes provide the basis for interpretation of ocular immunohistochemistry in dogs. Published immunophenotypes of primary ocular neoplasms are also reviewed.

show abstract

Adenoma of the non-pigmented ciliary epithelium: A rare intraocular tumor with unusual immunohistochemical findings

Cited by 13 publications

References 17 publications

Possible role of standardized echography complementing ultrasound biomicroscopy in tumors of the anterior eye segment: a study in a series of 13 patients

Possible role of standardized echography complementing ultrasound biomicroscopy in tumors of the anterior eye segment: a study in a series of 13 patients

Rare Histological Type of Adenoma of the Nonpigmented Ciliary Epithelium

Immunohistochemical Characteristics of Normal Canine Eyes

Contact Info

Product

Resources

About