Adenomyoepithelioma of the Breast: A Brief Diagnostic Review

Yoon, Jiyoon; Chitale, Dhananjay

doi:10.5858/arpa.2011-0404-rs

Cited by 53 publications

(41 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It lacks the papillary architecture which is frequently seen in adenomyoepithelioma. The myoepithelial cells tend to be smaller and more basaloid, and the arrangement of epithelial and myoepithelial cells is less irregular than that of adenomyoepithelioma [5, 18]. Immunohistologically, CD117 highlights the epithelial cells of adenoid cystic carcinoma [4, 19, 20] but is totally negative in malignant adenomyoepithelioma.…”

Section: Discussionmentioning

confidence: 99%

Malignant adenomyoepithelioma combined with adenoid cystic carcinoma of the breast: a case report and literature review

Yang

Wang

et al. 2014

Diagn Pathol

View full text Add to dashboard Cite

BackgroundMalignant adenomyoepithelioma and adenoid cystic carcinoma are both rare malignant epithelial-myoepithelial tumors of the breast. We report a very rare case with a malignant adenomyoepithelioma combining with adenoid cystic carcinoma in a single mass.Case presentationA 61-year-old female presented with a palpable painless mass in the right breast. Mammography revealed a large irregular dense shadow without obvious internal calcification. A simple lumpectomy was performed, and a 1.6cm well-circumscribed pale-tan nodule was presented. Histologically, the nodule was composed of two obscure lobules. One exhibited typical histological image of adenoid cystic carcinoma, the other one showed the image of epithelial-myoepithelial carcinoma of salivary gland, and support the diagnosis of biphasic malignant adenomyoepithelioma. Transition between the two lobules was gradual. Immunohistochemically, CK18 and P63 highlighted the epithelial and myoepithelial cells respectively in both lesions. CD117 was positive in the epithelial cells of adenoid cystic carcinoma, but was totally negative in malignant adenomyoepithelioma.ConclusionThis report is, to our knowledge, the first case that combines these two tumors in a single mass. In addition, we present a review of the literature. The histogenesis of these tumors is also discussed.Virtual SlidesThe virtual slide(s) for this article can be found here: http://med.motic.com/MoticGallery/Slide?id=D562817E-23C2-4F72-9823-86EF6DA40005&user=2C69F0D6-A478-4A2B-ABF0-BB36763E8025 and http://med.motic.com/MoticGallery/Slide?id=38BB7126-6FFB-4B66-A208-B8C0F528DCA8&user=2C69F0D6-A478-4A2B-ABF0-BB36763E8025

show abstract

Section: Discussionmentioning

confidence: 99%

Malignant adenomyoepithelioma combined with adenoid cystic carcinoma of the breast: a case report and literature review

Yang

Wang

et al. 2014

Diagn Pathol

View full text Add to dashboard Cite

show abstract

“…Total surgical excision with an adequate margin of uninvolved breast tissue was therefore recommended. [5,6,7] …”

Section: Discussionmentioning

confidence: 99%

Breast Adenomyoepithelioma with predominance of morules: a cytological dilemma.

Kshirsagar

Yadav

Gadgil

et al. 2017

APALM

View full text Add to dashboard Cite

Adenomyoepithelioma is a rare, benign proliferative tumour that can involve the breast. It is usually present as a solitary, unilateral, painless mass at the periphery of the breast in women range in age from 26 to 82 years (average 63 years). Tumour sizes range from 0.5 to 8 cm.(average size 2.5 cm).We report a case of adenomyoepithelioma of right breast in a 58 years old female since two months with diagnostic difficulty on cytology, especially with morules predominance that merits documentation due to its rarity.On physical examination, it was a single well defined, lobulated, non mobile, firm mass of 10 x 8 x 5 cm in upper outer quadrant of right breast without associated axillary lymphadenopathy. Sonomammography showed well defined lobulated right breast mass with macrolobulations and cystic changes suggestive of phyllodes tumour. Wide local excision was performed and histopathological study revealed adenomyoepithelioma which is confirmed by P63 immunostain.

show abstract

“…Recognition of the biphasic cellular elements and the characteristic overall architecture of the tumors in combination with immunohistochemistry are essential to establish the correct diagnosis. Therefore, adequate sampling of the tumor to identify these features is necessary (24) .…”

Section: Diagnosismentioning

confidence: 99%

Breast Adenomyoepithelioma

박상협¹,

송병주²,

Choi³

et al. 2020

Definitions

View full text Add to dashboard Cite

Adenomyoepithelioma is a biphasic neoplastic proliferation of luminal and myoepithelial cells. Patients are 22 to 92 years old, normally asymptomatic. It is either diagnosed as a palpable mass or as an occasional mammographic finding (1). Fine-needle aspiration cytology is the investigation of choice to diagnose (2) and immunohistochemistry is very useful in confirming the diagnosis (3). Adenomyoepithelioma is usually benign, although it may recur locally (4). Tubular variants and some lobular tumors with high mitotic activity or cytological atypia are particularly prone to local recurrence. Its treatment is complete local excision (5-7) and, in case of recurrence, a wider excision (5). Case Report: 47-year-old female with a breast mass on the external upper quadrant of the left breast. Ultrasound revealed an 8 millimeter homogeneous, well delimitated nodule with regular borders and medio-lateral mammography showed a well defined opaque mass with irregular borders. The anatomo-pathological and immunohistochemisty of the specimen from the needle core biopsy was inconclusive so an excisional biopsy was performed diagnosing a tubular adenomyoepithelioma. No additional treatment was performed with a follow-up of 20 months without recurrence. Review of published cases: 159 cases of adenomyoepithelioma almost all women mostly older than 45 years old. Adenomyoepithelioma is presented as a mass of on average 30 millimeters in either breast of lobular pattern most of the times. Adenomyoepithelioma demonstrated a borderline malignancy especially in women from 15 to 40 years of age or older than 80 years. Lobular pattern proved to be the most benign, while spindle pattern the most malignant variant and tubular pattern is the commonest one to recur. Low mitotic rates are associated with less recurrence or malignancy and high mitotic rates accompany adenomyoepitheliomas with great potential to metastasize. Conclusions: Adenomyoepithelioma affects women aged between 16 and 92 years in either breast. It may display a heterogeneous pattern and a borderline malignancy. Ultrasonographic images may play an important role as a first approach and fine-needle aspiration cytology combined with immunohistochemistry should define the diagnosis. Potential malignant adenomyoepitheliomas are associated with high mitotic activity, cytologic atypia (6) , necrosis and infiltrative borders (4). Metastases have only been documented in tumors 20 millimeter in diameter or larger (8) and distant metastases locations include lung, brain, jaw, soft tissues, thyroid, lymph nodes (mediastinal and axillary) and liver (6, 9-13) .

show abstract

Adenomyoepithelioma of the Breast: A Brief Diagnostic Review

Cited by 53 publications

References 28 publications

Malignant adenomyoepithelioma combined with adenoid cystic carcinoma of the breast: a case report and literature review

Malignant adenomyoepithelioma combined with adenoid cystic carcinoma of the breast: a case report and literature review

Breast Adenomyoepithelioma with predominance of morules: a cytological dilemma.

Breast Adenomyoepithelioma

Contact Info

Product

Resources

About