Adenomyoepithelioma of the breast with malignant features

Rasbridge, S. A.; Millis, Rosemary R.

doi:10.1007/s004280050145

Cited by 66 publications

(66 citation statements)

References 10 publications

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“…Presence of mitotic activity, necrosis, and cellular pleomorphism, and invasion at the periphery of the tumor indicate potential for locally aggressive behavior and/or metastasis which has been described in adenomyoepitheliomas of breast [18,19]. The present case did not exhibit any of these high risk features.…”

Section: Discussionsupporting

confidence: 56%

Adenomyoepithelioma of Skin

Sobti¹,

Gupta²,

Khurana³

et al. 2013

JCR

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Abstract:Background: Adenomyoepithelioma is an uncommon neoplasm that occurs almost exclusively in the breast and rarely described at other sites. It is a biphasic tumor that arises from both myoepithelial and epithelial cells.Case: We present a case of cutaneous adenomyoepithelioma in a 25 year old female patient presenting with a nodular lesion over the right cheek. Histopathological examination showed presence of dermal nodules composed of scattered tubules lined by cuboidal epithelial cells in a background sheet of myoepithelial cells. The epithelial and myoepithelial components were confirmed immunohistochemically using cytokeratin (CK) and smooth muscle antigen (SMA). Conclusion:Primary cutaneous adenomyoepithelioma is an uncommon benign tumor with a good prognosis. However, failure to achieve a free resection margin may result in local recurrence or rarely, malignant transformation. Therefore, it is important to make an accurate pathologic diagnosis followed by complete excision

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Section: Discussionsupporting

confidence: 56%

Adenomyoepithelioma of Skin

Sobti¹,

Gupta²,

Khurana³

et al. 2013

JCR

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“…7,8 In some cases, mammography, sonography, and frozen sectioning of AME may suggest malignancy, which has major implications in the differential diagnosis and treatment of the lesion. 6 To our knowledge, this is the first report of the color Doppler sonographic findings of AME. A B…”

Section: Tavassolimentioning

confidence: 68%

“…Although it is considered benign by nature, local recurrences and nodal and distant metastases in a bicellular pattern histologically similar to that of the primary tumor have been described. 1,[3][4][5][6]10,11 Recurrences have been attributed to incomplete resection because of the multinodularity and the peripheral intraductal extensions of the tumor. 1,11 Findings of high mitotic activity and cytologic atypia in both epithelial and myoepithelial cells may help in the differentiation of malignant and benign cases of AME.…”

Section: Discussionmentioning

confidence: 99%

Adenomyoepithelioma of the breast.

Tükel

Üstüner

Aytaç

2001

J of Ultrasound Medicine

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“…45,[63][64][65][66] Pure myoepithelial tumors have only rarely been reported in the breast 3,[67][68][69][70][71] and account for about 3% of all tumors of salivary glands. [72][73][74][75][76] The differential diagnosis include spindle cell tumors with glandular 72,[77][78][79] and/or squamous differentiation, 67 spindle cell adenocarcinomas, [80][81][82][83][84] and mesenchymal tumors. 37 Here, we have only studied one malignant myoepithelioma of the breast, which expressed K5/K14 and the myoid marker SMA, but not, or only focally and rather feebly, glandular keratins K7/K8/K18 and/or keratin K10.…”

Section: Discussionmentioning

confidence: 99%

K5/K14-positive cells contribute to salivary gland-like breast tumors with myoepithelial differentiation

et al. 2013

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Salivary gland-like tumors of the breast show a great variety of architectural patterns and cellular differentiations such as glandular, myoepithelial, squamous, and even mesenchymal phenotypes. However, currently little is known about the evolution and cellular differentiation of these tumors. For that reason, we performed an in situ triple immunofluorescence lineage/differentiation tracing (isTILT) and qRT-PCR study of basal (K5/K14), glandular (K7/K8/18), and epidermal-specific squamous (K10) keratins, p63, and smooth muscle actin (SMA; myoepithelial marker) with the aim to construct and trace different cell lineages and define their cellular hierarchy in tumors with myoepithelial differentiation. isTILT analysis of a series of 28 breast, salivary, and lacrimal gland tumors, including pleomorphic adenomas (n ¼ 8), epithelial-myoepithelial tumors (n ¼ 9), and adenoid cystic carcinomas (n ¼ 11) revealed that all tumor types contained K5/K14-positive progenitor cells in varying frequencies from a few percent up to 15%. These K5/K14-positive tumor cells were found to differentiate to glandular-(K8/18-positive) and myoepithelial-lineage (SMA-positive)-specific cells and were also shown to generate various heterologeous cell differentiations such as squamous and mesenchymal progenies. p63 was co-expressed with K5/K14 in basal-like progenitor cells, myoepithelial, and squamous cells but not in glandular cells. Our results show that the corresponding counterpart tumors of breast and salivary/lacrimal glands have identical cellular compositions. Taken together, our isTILT and RNA-expression data indicate that look-alike tumors of the breast represent a special subgroup of basal-type tumors with benign or usually low malignant potential.

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Adenomyoepithelioma of the breast with malignant features

Cited by 66 publications

References 10 publications

Adenomyoepithelioma of Skin

Adenomyoepithelioma of Skin

Adenomyoepithelioma of the breast.

K5/K14-positive cells contribute to salivary gland-like breast tumors with myoepithelial differentiation

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