Adenomyosis and Uterine Fibroids in Terms of Comorbidity (Literature Review)

The review was made based on https://cyberleninka.ru/, PubMed, MedArt and https://rucml.ru/. Uterine fibroid is one of the most common noninflammatory diseases of female reproductive system of reproductive age. Estrogens and progesterone are tightly connected with various growth factors such as transforming growth factor beta, insulinlike growth factor, endothelial growth factor etc. Dysfunction of sex steroids, alteration of myometrium vascularization and proinflammatory changes of endometrium, associated with leiomyoma can prevent from adequate preparation of endometrium to implantation. The situation is often complicated by combination of leiomyoma and adenomyosis. Pregnancy in women with leiomyoma is associated with increased risk of miscarriage, preeclampsia and placental insufficiency. Isthmic localization of uterine fibroid is considered to be the most unfavorable as it increases the risk of cervical insufficiency. Thus, uterine fibroid is a serious reproductive problem associated with fertility reduction and other problems with childbearing.

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Uterine fibroids and fertility: a modern view of the problem. A literature review

Bezhenar

Линде

Arakelyan

et al. 2022

Journal of obstetrics and women's diseases

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show abstract

Adenomyosis and fertility: a modern view of the problem. A literature review

Bezhenar

Линде

Arakelyan

et al. 2022

Journal of obstetrics and women's diseases

View full text Add to dashboard Cite

This literature review is based on resources from the following databases: CyberLeninka, PubMed, MedArt, and the Central Scientific Medical Library (I.M. Sechenov First Moscow State Medical University, Moscow, Russia). Adenomyosis is a common non-infectious uterine pathology associated with the risk of infertility and obstetric problems. The local inflammation that develops in adenomyosis reduces the probability of blastocyst implantation and creates an unfavorable environment for the development of the embryo. Adenomyosis reduces the effectiveness of assisted reproductive technology. During the pregnancy in adenomyosis, the risk of incomplete and prolonged pregnancy increases at almost all stages. Besides, the risk of massive hemorrhage increases during pregnancy, childbirth and the early postpartum period. The presented review helps to assess the pathogenetic mechanisms underlying the negative effect of adenomyosis on womens fertility based on data obtained over the past ten years.

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Adenomyosis and Uterine Fibroids in Terms of Comorbidity (Literature Review)

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Uterine fibroids and fertility: a modern view of the problem. A literature review

Uterine fibroids and fertility: a modern view of the problem. A literature review

Adenomyosis and fertility: a modern view of the problem. A literature review

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