Adenosine analogs inhibit fighting in isolated male mice

Palmour, Roberta M.; Lipowski, Christopher J.; C, Simon; Ervin, Frank R.

doi:10.1016/0024-3205(89)90367-6

Cited by 21 publications

(8 citation statements)

References 22 publications

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“…In general, the A 2a -/-residents engaged in three to five times more aggressive encounters than the WT residents. These results are consistent with the inhibition in fighting and associated agonistic behaviors in isolated male mice treated with adenosine analogues (Palmour et al 1989). The biochemical mechanism of adenosine receptor action with respect to aggression is unknown but may include neuromodulatory effects on the release of other neurotransmitters.…”

Section: Adenosine a 2a Receptorsupporting

confidence: 85%

Aggression in Knockout Mice

Nelson

Chiavegatto²

2000

ILAR Journal

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Section: Adenosine a 2a Receptorsupporting

confidence: 85%

Aggression in Knockout Mice

Nelson

Chiavegatto²

2000

ILAR Journal

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“…[2,46,47]. Other common behavioural disturbances such as nociceptive, locomotar alterations and pain observed upon envenomation may also be brought about by adenosine [2,[48][49][50][51][52][53][54][55]. Therefore, it is suggested that adenosine may play a central role in envenomation strategies of prey immobilization [2,3].…”

Section: Adenosine Generation From Phosphatasesmentioning

confidence: 98%

The Pharmacological Role of Phosphatases (Acid and Alkaline Phosphomonoesterases) in Snake Venoms related to Release of Purines ‐ a Multitoxin

Dhananjaya

D'Souza

2010

Basic Clin Pharma Tox

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Snake venom components, acting in concert in the prey, cause their immobilization and initiate digestion. To achieve this, several hydrolytic enzymes of snake venom have evolved to interfere in various physiological processes, which are well defined. However, hydrolytic enzymes such as phosphatases (acid and alkaline phosphomonoesterases) are less studied and their pharmacological role in venoms is not clearly defined. Also, they show overlapping substrate specificities and have other common biochemical properties causing uncertainty about their identity in venoms. The near-ubiquitous distribution of these enzymes in venoms, suggests a significant role for these enzymes in envenomation. It appears that these enzymes may play a central role in liberating purines (mainly adenosine) - a multitoxin and through the action of purines help in prey immobilization. However, apart from this, these enzymes could also possess other pharmacological activities as venom enzymes have been evolved to interfere in diverse physiological processes. This has not been verified by pharmacological studies using purified enzymes. Further research is needed to biologically characterize these enzymes in snake venoms, such that their role in venom is clearly established.

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“…The involvement of adenosine in regulating complex central functions, such as aggression (Palmour et al 1989), cognition (Normile et al 1994;Hooper et al 1996) and anxiety, has also been investigated. At present, the role of adenosine in modulating the a¤ective state is still under debate.…”

Section: Introductionmentioning

confidence: 99%

Adenosine A 1 receptors modulate anxiety in CD1 mice

et al. 1998

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The effect of the selective adenosine A1 receptor agonist 2-chloro-N6-cyclopentyladenosine (CCPA) was investigated in CD1 mice by the elevated plus-maze and the light/dark test, two models for measuring anxiety in rodents. CCPA, administered i.p., had an anxiolytic effect at 0.3 nmol/kg in the elevated plus-maze and at 1 nmol/kg in the light/dark test. Brain levels of 22 nM were found after administration of 100 nmol/kg CCPA, as measured by ex vivo binding experiments. These values are consistent with the occupancy of adenosine A1 but not A2 receptors by CCPA, and suggest that the anxiolytic-like action of CCPA may be mediated by centrally located adenosine A1 receptors. Both CPT, a selective adenosine A1 receptor antagonist, and IBMX, a non-selective adenosine antagonist, had an anxiogenic effect in the two tests. It is thus possible that purinergic neurons may be involved in the tonic modulation of affective state in mice.

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Adenosine analogs inhibit fighting in isolated male mice

Cited by 21 publications

References 22 publications

Aggression in Knockout Mice

Aggression in Knockout Mice

The Pharmacological Role of Phosphatases (Acid and Alkaline Phosphomonoesterases) in Snake Venoms related to Release of Purines ‐ a Multitoxin

Adenosine A 1 receptors modulate anxiety in CD1 mice

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