Adenosine and adenosine receptors in colorectal cancer

Hajizadeh, Farnaz; Masjedi, Ali; Asl, Sima Heydarzedeh; Kiani, Fariba Karoon; Peydaveisi, Makwan; Ghalamfarsa, Ghasem; Jadidi‐Niaragh, Farhad; Севбитов, А.В.

doi:10.1016/j.intimp.2020.106853

Cited by 29 publications

(17 citation statements)

References 113 publications

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“…In the late stages of CAC, a number of TRegs increasingly colonize mesenteric lymph nodes [ 32 ]. CD39 + γδ TRegs act as suppressors of T cell activity more than other Tregs, and their expression depends on TGFβ1 [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

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The Complex Network between Inflammation and Colorectal Cancer: A Systematic Review of the Literature

Percario

Panaccio

Mola

et al. 2021

Cancers

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Background: colorectal cancer (CRC) has a multifactorial etiology which comprises microbiota, genetic predisposition, diet, environmental factors, and last but not least, a substantial contribution by inflammation. The aim of this study is to conduct a systematic review of the literature regarding the strong link between inflammation and colorectal cancer. Methods: A systematic review of the literature on PubMed (Medline), Scopus, Cochrane and EMBase databases was performed, following the PRISMA 2020 guidelines. Each paper was reviewed by two groups of researchers in a single-blind format by using a pre-planned Microsoft© Excel® grid. Results: Using automated research filters, 14,566 studies were included, but 1% was found significant by the reviewers. Seventy pathways of inflammation were described in the sequence of inflammation-carcinogenesis, and anti-tumorigenic molecules were also found. Conclusion: several studies suggest a strong role of inflammation in the tumorigenesis of colorectal cancer through different pathways: this may have a diagnostic and clinical role and also therapeutic purpose in preventing carcinogenesis by treating inflammation. In vitro tests support this theory, even if many other clinical trials are necessary. The present paper was registered in the OpenScience Framework registry (Identifier: DOI 10.17605/OSF.IO/2KG7T).

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Section: Resultsmentioning

confidence: 99%

“…Its increasing expression is directly correlated with tumor progression and poor outcome. It is related to the expression of β-catenin and increases the expression of EGFR [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

The Complex Network between Inflammation and Colorectal Cancer: A Systematic Review of the Literature

Percario

Panaccio

Mola

et al. 2021

Cancers

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“…It also protects stomach tissues, inhibits tumor growth, reduces plasma glucose [30] . Adenosine, an ATP‐derived nucleoside, is a crucial modulator of immune responses in the neoplastic environment [34] . Glutamine not only has potential as an immunomodulatory nutrient, [35] but can make important contributions to cancer therapy [36] .…”

Section: Discussionmentioning

confidence: 99%

Organ‐ and Age‐Specific Differences ofDioscorea polystachyaCompounds Measured by UPLC‐QTOF/MS

Guo

et al. 2021

Chemistry & Biodiversity

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Dioscorea polystachya, named Chinese yam, is widely cultivated as a functional food and natural medicine in China. There is currently little information about the chemical characteristics of Dioscorea polystachya in different organs (tuber cortex and tuber flesh) and at various ages. In this study, an ultra‐high‐performance liquid chromatography coupled to quadrupole time‐of‐flight mass spectrometry (UPLC‐QTOF/MS) was used to profile chemical compounds in Dioscorea polystachya. As a result, thirty‐eight compounds were detected in yam tuber cortex and tuber flesh. More compounds were detected in yam tuber cortex than in tuber flesh. Compounds such as dehydroepiandrosterone, allantoin and flavonoids were selected as biomarker candidates. Dehydroepiandrosterone was found more abundant in tuber flesh, while allantoin and flavonoids showed higher levels in tuber cortex. Furthermore, the levels of dioscin, malvalic acid and sucrose differed significantly among age groups and were highest in the tubers at 2 years. While the levels of allantoin, adenosine and glutamine increased with the growing years and were highest at 4 years. Thus, 2‐year old Dioscorea polystachya tubers could be harvested to prepare dioscin, malvalic acid and sucrose supplements. The 4‐year‐old Dioscorea polystachya tubers would be the best choice for obtaining a large amount of allantoin and adenosine in industrial production.

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“…Those cells express CD73 and CD39 endonucleotidases, which take part in adenosine production [37]. The overexpression of the latter was connected to an increased number of occurring liver metastasis in colorectal cancer (CRC) in the murine model and correlates with the worst prognosis and a poor outcome in patients [38]. Adenosine, whose production from ATP and AMP is enhanced in the presence of Treg, affects tumor development by activating PI3K/Akt/mTOR pathway and upregulating metalloproteinases that stimulate invasiveness and migration capacity of malignant cells [39].…”

Section: Ido1 and Its Role In Cancer Developmentmentioning

confidence: 99%

Not Only Immune Escape—The Confusing Role of the TRP Metabolic Pathway in Carcinogenesis

Kwiatkowska

Hermanowicz

Przybyszewska-Podstawka

et al. 2021

Cancers

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Background: The recently discovered phenomenon that cancer cells can avoid immune response has gained scientists' interest. One of the pathways involved in this process is tryptophan (TRP) metabolism through the kynurenine pathway (KP). Individual components involved in TRP conversion seem to contribute to cancerogenesis both through a direct impact on cancer cells and the modulation of immune cell functionality. Due to this fact, this pathway may serve as a target for immunotherapy and attempts are being made to create novel compounds effective in cancer treatment. However, the results obtained from clinical trials are not satisfactory, which raises questions about the exact role of KP elements in tumorigenesis. An increasing number of experiments reveal that TRP metabolites may either be tumor promoters and suppressors and this is why further research in this field is highly needed. The aim of this study is to present KP as a modulator of cancer development through multiple mechanisms and to point to its ambiguity, which may be a reason for failures in treatment based on the inhibition of tryptophan metabolism

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Adenosine and adenosine receptors in colorectal cancer

Cited by 29 publications

References 113 publications

The Complex Network between Inflammation and Colorectal Cancer: A Systematic Review of the Literature

The Complex Network between Inflammation and Colorectal Cancer: A Systematic Review of the Literature

Organ‐ and Age‐Specific Differences ofDioscorea polystachyaCompounds Measured by UPLC‐QTOF/MS

Not Only Immune Escape—The Confusing Role of the TRP Metabolic Pathway in Carcinogenesis

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