Adenosine and sleep–wake regulation

Basheer, Radhika; Strecker, Robert E.; Thakkar, Mahesh; McCarley, Robert W.

doi:10.1016/j.pneurobio.2004.06.004

Cited by 508 publications

(361 citation statements)

References 142 publications

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“…However, CPA-induced sleep was not observed in A 2A receptor knockout mice, suggesting that the effect of high concentration of CPA is due to its loss of selectivity for A 1 receptors. Thus, although the subtype of adenosine receptor responsible for sleep regulation is still a matter of debate (Basheer et al, 2004), these results strongly suggest a predominant role of A 2A receptors in sleep regulation.…”

Section: Adenosine a 1 And A 2a Receptors In Sleep Regulationmentioning

confidence: 85%

“…More than 30 so-called endogenous sleep substances in the brain, CSF, urine, and other organs and tissues of animals have been reported since then by numerous investigators. For example, delta-sleep-inducing peptide, muramyl peptides, uridine, oxidized glutathione, vitamin B 12 , prostaglandin (PG) D 2 and adenosine have been identified as endogenous somnogenic substances (Inoué, 1989;Hayaishi, 1991;Basheer et al, 2004). Among these compounds, PGD 2 and adenosine are the most plausible candidates for endogenous sleep-promoting substances.…”

Section: Adenosine and Its Role In Sleepmentioning

confidence: 99%

“…For example, adenosine and its stable analogues are known to induce sleep when administered to rats, cats, and other experimental animals (Basheer et al, 2004). The concentration of extracellular adenosine increases in the cortex and basal forebrain during sleep deprivation of cats and decreases during the recovery period after sleep deprivation (Pokka-Heiskanen et al, 2000).…”

Section: Adenosine and Its Role In Sleepmentioning

confidence: 99%

“…A 2A receptors appear to be involved in some adenosine-regulated brain functions previously thought to be mediated solely by A 1 receptors. Adenosine is an endogenous sleep-promoting substance and it is currently believed that A 1 receptors in the cholinergic basal forebrain mediate sleepinducing mechanisms (recently reviewed in Basheer et al, 2004). Here we review evidence demonstrating a key role of hypothalamic A 2A receptors in sleep regulation.…”

Section: Introductionmentioning

confidence: 99%

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Adenosine A2A receptors in ventral striatum, hypothalamus and nociceptive circuitry

Ferré

Diamond

Goldberg

et al. 2007

Progress in Neurobiology

128

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Adenosine A 2A receptors localized in the dorsal striatum are considered as a new target for the development of antiparkinsonian drugs. Co-administration of A 2A receptor antagonists has shown a significant improvement of the effects of L-DOPA. The present review emphasizes the possible application of A 2A receptor antagonists in pathological conditions other than parkinsonism, including drug addiction, sleep disorders and pain. In addition to the dorsal striatum, the ventral striatum (nucleus accumbens) contains a high density of A 2A receptors, which presynaptically and postsynaptically regulate glutamatergic transmission in the cortical glutamatergic projections to the nucleus accumbens. It is currently believed that molecular adaptations of the cortico-accumbens glutamatergic synapses are involved in compulsive drug seeking and relapse. Here we review recent experimental evidence suggesting that A 2A antagonists could become new therapeutic agents for drug addiction. Morphological and functional studies have identified lower levels of A 2A receptors in brain areas other than the striatum, such as the ventrolateral preoptic area of the hypothalamus, where adenosine plays an important role in sleep regulation. Although initially believed to be mostly dependent on A 1 receptors, here we review recent studies that demonstrate that the somnogenic effects of adenosine are largely mediated by hypothalamic A 2A receptors. A 2A receptor antagonists could therefore be considered as a possible treatment for narcolepsy and other sleep-related disorders. Finally, nociception is another adenosine-regulated neural function previously thought to mostly involve A 1 receptors. Although there is some conflicting literature on the effects of agonists and antagonists, which may partly be due to the lack of selectivity of available drugs, the studies in A 2A receptor knockout mice suggest that A 2A receptor antagonists might have some therapeutic potential in pain states, in particular where high intensity stimuli are prevalent.

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Section: Adenosine a 1 And A 2a Receptors In Sleep Regulationmentioning

confidence: 85%

Section: Adenosine and Its Role In Sleepmentioning

confidence: 99%

Section: Adenosine and Its Role In Sleepmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Adenosine A2A receptors in ventral striatum, hypothalamus and nociceptive circuitry

Ferré

Diamond

Goldberg

et al. 2007

Progress in Neurobiology

128

View full text Add to dashboard Cite

show abstract

“…Adenosine is a key neuromodulator highly implicated in the sleep-wake literature (Basheer et al 2004). Adenosine levels are known to fluctuate throughout the day, peaking during the height of the active period and then diminishing over the animal's resting period in both the hippocampus and the neostriatum (Huston et al 1996).…”

Section: Adenosine and Astrocytesmentioning

confidence: 99%

The impact of sleep loss on hippocampal function

2013

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Hippocampal cellular and molecular processes critical for memory consolidation are affected by the amount and quality of sleep attained. Questions remain with regard to how sleep enhances memory, what parameters of sleep after learning are optimal for memory consolidation, and what underlying hippocampal molecular players are targeted by sleep deprivation to impair memory consolidation and plasticity. In this review, we address these topics with a focus on the detrimental effects of post-learning sleep deprivation on memory consolidation. Obtaining adequate sleep is challenging in a society that values "work around the clock." Therefore, the development of interventions to combat the negative cognitive effects of sleep deprivation is key. However, there are a limited number of therapeutics that are able to enhance cognition in the face of insufficient sleep. The identification of molecular pathways implicated in the deleterious effects of sleep deprivation on memory could potentially yield new targets for the development of more effective drugs.

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Sleep and Waking Across the Life Span

Huber¹,

Tononi

2009

Handbook of Neuroscience for the Behavioral Sciences

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Adenosine and sleep–wake regulation

Cited by 508 publications

References 142 publications

Adenosine A2A receptors in ventral striatum, hypothalamus and nociceptive circuitry

Adenosine A2A receptors in ventral striatum, hypothalamus and nociceptive circuitry

The impact of sleep loss on hippocampal function

Sleep and Waking Across the Life Span

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