Adenosine deaminase activity in the serum and malignant tumors of breast cancer: The assessment of isoenzyme ADA1 and ADA2 activities

Aghaei, Mahmood; Karami-Tehrani, Fatemeh; Salami, Siamak; Atri, Morteza

doi:10.1016/j.clinbiochem.2005.05.015

Cited by 60 publications

(57 citation statements)

References 19 publications

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“…adenosine. Increased activity of ADA has been reported in breast cancer patients in different stages as compared to controls [16][17][18]. It is evident that oxidative stress is the generator of inflammatory conditions in breast cancer; hence there is need to establish the robust biomarkers for diagnosis and prognosis of the disease.…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress and Its Relationship With Adenosine Deaminase Activity in Various Stages of Breast Cancer

Mahajan¹,

Tiwari²,

Sharma³

et al. 2012

Ind J Clin Biochem

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Reactive oxygen species (ROS) cause damage to the DNA producing mutations and formation of tumours such as carcinoma of breast. Tumour cells are known to produce ROS at a greater pace than the non-transformed cells. The increased production of reactive oxygen species causes oxidative stress leading to cell proliferation and hence increased inflammatory conditions. The present study was aimed to investigate the role of oxidative stress in the pathogenesis of breast cancer. Females suffering from breast cancer had significantly decreased Superoxide dismutase (SOD) and reduced glutathione (GSH) levels in comparison to normal females. The compromised antioxidant defence system produces the oxidative stress which in turn creates the inflammatory response shown by concomitant increased adenosine deaminase (ADA) activity in female patients. ADA diminishes the protective molecule adenosine. There were significant variations (p \ 0.01) in ADA activity with different clinical stages (stage 1-4) of breast cancer suggesting thereby that estimation of ADA activity can be used as a diagnostic tool to detect the stage of cancer along with cytological studies. Mastectomy was performed and post-operatively serum SOD and ADA activity and plasma GSH levels were estimated. There was a statistically significant increase in activity of SOD and levels of GSH while serum ADA activity decreased significantly, suggesting thereby that oxidative stress is responsible for increased cell proliferation and hence the inflammatory conditions in CA breast that got ameliorated post-operatively.

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Section: Introductionmentioning

confidence: 99%

Oxidative Stress and Its Relationship With Adenosine Deaminase Activity in Various Stages of Breast Cancer

Mahajan¹,

Tiwari²,

Sharma³

et al. 2012

Ind J Clin Biochem

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“…ADA levels are found to be increased in effusions related with tuberculosis. Measurement of ADA in clinical practice is frequently considered as a noninvasive diagnostic test for tuberculosis with 90-100% sensitivity and 89-100% specificity (4,7,13). Furthermore, it has been shown in several studies that ADA activities may be useful both in the diagnosis and monitoring of some malignancies (7,14).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, ADA production by neoplastic cells is increased (4,7) and it could be assumed that respiratory secretions from lung cancer patients may contain high levels of ADA. So far, however, the measurement of ADA in bronchoalveolar lavage (BAL) and bronchial washings has proved unhelpful (16).…”

Section: Introductionmentioning

confidence: 99%

“…Lung cancer causes more deaths than the other three most common cancers combined, i.e., colon, breast and prostate (1,2). In an attempt to describe human lung cancer, many studies have concentrated on enzyme activities (3)(4)(5). In addition, some studies established alteration of enzyme activity in bronchoalveolar lavage (6,7).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, some studies established alteration of enzyme activity in bronchoalveolar lavage (6,7). To better understand purine enzymology in lung cancer, more attention has been paid to the investigation of the interrelationship among the carcinogenic process and enzyme activity (de novo and salvage pathways) for purine biosynthesis (3,4).…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic Utility of Adenosine Deaminase in Serum and Bronchoalveolar Lavage Fluid for Screening Lung Cancer in Western Iran

Nikkhoo¹,

Sigari²,

Ghaderi³

et al. 2013

Journal of Medical Biochemistry

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SummaryBackground: This study aimed to determine adenosine deaminase (ADA) activity as a possible screening tool in lung cancer patients. Methods: Blood samples were collected from 30 subjects with positive pathological tests and 62 patients with negative pathological tests as a control group. The enzymatic activity of total ADA and its isoenzymes was determined. Results: tADA and ADA2 isoenzyme activity was significantly higher in cancerous patients compared to benign controls in serum and BAL fluid. Using a cut-off level of respectively 35.22 U/L and 31.80 U/L for BAL total ADA and ADA2, sensitivity and specificity were 100% and 81% for total ADA and 95% and 98% for ADA2. Conclusions: Adenosine deaminase may play important roles in the pathophysiology of lung cancer and because of its

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Adenosinergic signaling as a target for natural killer cell immunotherapy

Wang

Matosevic

2018

J Mol Med

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Purinergic signaling through adenosine plays a key role in immune regulation. Hypoxia-driven accumulation of extracellular adenosine results in the generation of an immunosuppressive niche that fuels tumor development. Such immunometabolic modulation has shown to be a promising therapeutic target through blockade of adenosine receptors which mediate adenosine's immunosuppressive function, or cancer-associated ectonucleotidases CD39 and CD73 that catalyze the synthesis of adenosine. Adenosinergic signaling heavily implicates natural killer cells through both direct and indirect effects on their cytolytic activity, expression of cytotoxic granules, interferon-γ, and activating receptors. Continuing work has uncovered multiple checkpoints linked to adenosine within the purinergic signaling cascade as contributing to immune evasion from NK cell effector function. Here, we discuss these checkpoints and the recent body of work that focuses on adenosinergic signaling as a target for natural killer cell of cancer.

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Adenosine deaminase activity in the serum and malignant tumors of breast cancer: The assessment of isoenzyme ADA1 and ADA2 activities

Cited by 60 publications

References 19 publications

Oxidative Stress and Its Relationship With Adenosine Deaminase Activity in Various Stages of Breast Cancer

Oxidative Stress and Its Relationship With Adenosine Deaminase Activity in Various Stages of Breast Cancer

Diagnostic Utility of Adenosine Deaminase in Serum and Bronchoalveolar Lavage Fluid for Screening Lung Cancer in Western Iran

Adenosinergic signaling as a target for natural killer cell immunotherapy

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